Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

DMD 5244 (Immunity) > periodontal disease and immunology (complete) > Flashcards

periodontal disease and immunology (complete) Flashcards

1
Q

what are the components of the periodontium

A 
gingiva
gingival attachement
cementum
periodontal ligament
alveolar bone
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

which parts of the periodontium are tooth supporting structures

A

cementum
periodontal ligament
alveolar bone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what are the cells surrounding the periodontal ligament

A

connective tissue cells
epithelial rest cells
immune system cells (Neutrophils, lymphocytes, macrophages, mast cells, eosinophils)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what is periodontal disease

A

a broad group of pathological alterations to the periodontal tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what is the only etiology of periodontal disease

A

bacterial plaque

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what is bacterial plaque

A

the colonization of subgingival regions by specific groups of organisms (bacterial mass)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

where does bacterial plaque attach

A

tooth surface above and below the gingival margin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what are the direct effects of bacterial plaque on the periodontium

A

invasion
release of exotoxins
cell constituents
enzymes (proteases)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what are the indirect effects of bacterial plaque on the periodontium

A

immunological and other host responses (often destructive)

loss of periodontal tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what are the two types of periodontitis

A

chronic and aggressive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what is periodontitis

A

an inflammation based infection to the supporting structures of the teeth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what effect do systemic diseases have on periodontitis

A

they modify it

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

which type of periodontitis is most common in adults

A

chronic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

is the severity of chronic periodontitis consistent with the plaque and calculus formation

A

yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what happens to the tissues in chronic periodontitis

A

they may be red or purplish

you may lose attachment and bone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

how quickly does chronic periodontitis progress

A

slowly or moderately

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

is the severity of aggressive periodontitis consistent with the plaque and calculus

A

nope

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

how fast is the destruction of tissue progression in aggressive periodontitis

A

rapid

19
Q

are there genetic factors involved in aggressive periodontitis

A

yes

20
Q

what bacteria is most commonly associated with aggressive periodontitis

A

actinobacillus actinomycetemcomitans

21
Q

what is the activity of PMNs and macrophages like in aggressive periodontitis

A

abnormal PMN function and hyperresponsive macrophages

22
Q

what are the two kinds of aggressive periodontitis

A

Localized (LAP)

generalized (GAP)

23
Q

which type of aggressive periodontitis has a strong Ab response, which type has a poor Ab response

A

localized has a strong Ab response

generalized has a weak Ab response

24
Q

what are the characteristics of localized aggressive periodontitis

A
  1. early onset
  2. associated with actinobacillus actinomycetemcomitans
  3. abnormal neutrophil function
  4. destroys around 1st molars and incisors
  5. AKA juvenile periodontitis
25
Q

what are the characteristics of generalized aggressive periodontitis

A
  1. rapid attachment and bone loss
  2. no obvious symptoms of systemic disease
  3. destruction isn’t proportional to plaque
  4. genetic factor
  5. specific bacteria
  6. early onset
26
Q

are all bacterial plaque equally pathogenic

A

nope

27
Q

what are the bacteria associated with periodontitis

A

Porphyromonas gingivalis
Prevotella intermedia
Bacteroides forsythus
Campylobacter rectus

28
Q

what bacteria is associated with aggressive periodontitis

A

Actinobacillus actinomycetemcomitans (Aa)

29
Q

what are the virulence traits of periodontal pathogens,

A 
proteases
hemagglutinins
LPS
Fimbriae
Polysaccharide capsule
30
Q

what do proteases do for periodontal pathogens

A

degrade host proteins

31
Q

what do hemagglutinins do for periodontal pathogens

A

they are responsible for bacterial binding to the host cell receptors

32
Q

what does LPS do for periodontal pathogens

A

slightly endotoxic

33
Q

what does Fimbriae do for periodontal pathogens

A

helps in adherence, colonization, and periodontal destruction

34
Q

what does the polysaccharide capsule do for periodontal pathogens

A

inhibit phagocytosis and MAC medaited cytolysis

35
Q

how does P. gingivalis induce inflammation and bleeding and why

A

hemagglutinins and proteases lyse RBCs and extract the nutrients for rapid growth

36
Q

what do the proteases of periodontal pathogens lyse

A

RBCs
serum Abs
complement proteins
cytokines

37
Q

what is responsible for bone resorption

A

PGE2

38
Q

how do you combat PGE2 and bone resorption

A

NSAIDs and dexamethasone

39
Q

early periodontal lesions are characterized by

A

T-cells and macrophages

40
Q

established and advanced periodontal lesions are characterized by

A

B cells and plasma cells

41
Q

what controls the progression from T-cells and macrophage in early periodontal lesions to B-cells and plasma cells in advanced periodontal lesions

A

host Th-derived cytokines

42
Q

early clinical gingival lesions correlate with which type of immune response and which cytokines

A

TH1 type response
with IL-12 and IFN-y
protective immunity

43
Q

established gingival lesions correlate with which type of immune response and which cytokines

A

TH2 response
IL-4, IL-10, IL-13
chronic periodontitis

44
Q

what type of immune response leads to aggressive periodontitis

A

TH-1 dependent Ab type

high IgG2

DMD 5244 (Immunity) (16 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions