Perinatal Brain Injury and Designing Flashcards
1
Q
What sort of process is a brain injury?
A
An evolving process
2
Q
What does brain injury being an evolving process implicate?
A
- Acute cell loss not only occurs during the insult (most cells diet afterwards)
3
Q
What is acute cell loss important for?
A
Acute cell loss is important for the subsequent architecture of the brain
4
Q
When can we try and treat brain injury?
A
Neuroprotection is best done during the recovery phase.
Insult- recovery- re-organisation
5
Q
What is an example trail of neuroprotection?
A
Selective head cooling with mild systemic hypothermia after neonatal encephalopathy. Multicenter trial
6
Q
What was the method of the head cooling trial?
A
- Cerebral hypothermia
- Brained cooled to 33-34 C
- On term babies who suffered birth asphyxia
Found to reduce brain damage
7
Q
When is the best time to use cerebral hypothermia?
A
During the latent phase
