Pentose Phosphate Pathway

Question 1

What is the pentode phosphate pathway

Answer 1

Primarily anabolic

Question 2

What are the 3 main functions of pentode phosphate pathway

Which is most important

Answer 2

NADPH synthesis !!!!!

Hexoses to pentoses

Oxidative degradation of pentoses

Question 3

What can ribose 5 phosphate be used for

Answer 3

DNA/RNA/ATP

NAD/ FAD

Question 4

What can NADPH be used for (3)

Answer 4

FA

Steroids

DNA

Question 5

Where is NADPH synthesis most prominent

Answer 5

Mammary gland

Liver

Adrenal cortex

Rapidly proliferating cells

Question 6

G6P —> 6PLactone

Answer 6

G-6-P DH

Question 7

6PL —> 6phosphogluconate

Answer 7

Lactonase

Question 8

6P —>Ribulose 5-phosphate

Answer 8

Phosphogluconate DH

Question 9

Ribulose 5phosphate —> ribose 5 phosphate

Answer 9

Phosphopentose isomerase

Question 10

What converts ribose 5phosphate —> glyceraldehyde 3 phosphate

Answer 10

Transketolase

Question 11

Transketolase deficiency (2)

Answer 11

Thiamine deficiency

Wernjcke-korsakoff Syndrome

Question 12

Transketolase (C))

Answer 12

C5 + C5 = C3 + C7

C5 + C4 = C3 + C6

Question 13

translaldose (C)

Answer 13

C3 + C7 —> C4 + C6

Question 14

What promotes G-6P rate limiting step

Answer 14

NADP (low energy)

Question 15

Ck11

Answer 15

Works with GSK3 to inhibit synthase