PDH Flashcards by ryan seed | Brainscape

Q

Where is PDH found

A

Mitochondria

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Q

What subunits are found on PDH

A

E1/2/3

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Q

What type of reaction does PDH convert

A

Irreversible reaction

Oxidative decarboxylation

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Q

Write equation that PDH catalysed

A

Pyruvate + NAD + CoA

= Acetyl CoA + NADH + CO2

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Q

What allosterism promotion promotes PDH (4)

A

Ca2+

AMP

CoA

NAD+

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Q

What deactivates PDH via allosterism

A

Acetyl CoA/CoA

FA

NADH

ATP

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Q

What activates PDH via DEPHOSPHORYLATION

A

Insulin

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Q

What deactivates PDH via phosphorylation

A

Glucagon

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Q

What occurs on E1

A

Pyruvate dehydrogenase gets rid of CO2 from pyruvate

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Q

What happens at E2

A

CoA-SH forms Acetyl CoA

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Q

What happens at E3

A

NAD —> NADH + H

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Q

What converts Acetyl-CoA into citrate

A

Citrate synthase

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Q

What promotes citrate synthase

What deactivates citrate synthase

A

ADP

ATP

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Q

What converts isocitrate into a-ketogluterate +NADH

A

IDH

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Q

What promotes IDH

A

ADP

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Q

What can a-ketogluterate be used for

A

Amino acid synthesis

Q

What converts a-ketogluterate into succinyl-CoA +NADH

A

A-KG DH

Q

What promotes a-KG DH

What inactivates it

A

Ca2+

Succinyl CoA (allosterism)

Q

What can succinyl CoA be used for

A

Haem synthesis

Q

Pyruvate dehydrogenase converts what

Under what conditions

A

Pyruvate to lactate

Aerobic conditions

Q

Pyruvate to lactate

Under what conditions

A

Lactate dehydrogenase

Anaerobic