Glycogen Flashcards
G6P enters the ER via what transporter
T1
What transporter does Pi use in ER
T3
What does glycogen phosphorylase need to form G1P
Pi
On glycogen phosphorylase what subunits does it have to lead to ACTIVATION
2 subunits with serine residue
Can be phosphorylated
What stimulates glycogen phosphorylase
Glucagon
Epinephrine
Ca2+
Allosterism
What stimulates glycogen synthase
Insulin
G6P
Allosterism
What does glycogen synthase need to form glycogen
G1P + UTP
= UDP-glucose +PPi
UDP-glucose +glycogen = glycogen+UDP
Phosphorylation of glycogen synthase is what
Inactivation
GSK3 does what
Phosphorylates glycogen synthase
Makes it inactive
What inhibits GSK3
Insulin
What activates glycogen synthase enzyme?
PP1
What activates PP1
Insulin
Glucose
G6P
What happens if epinephrine acts on the liver (3)
Increase glycogenenolysis /gluconeogenesis
Decrease glycolysis
What happens if epinephrine acts on skeletal muscle (2)
Increase in glycogenolysis/glycolysis
What’s the difference between epinephrine acting on liver than skeletal muscle
Liver wants to make blood glucose for blood stream
Skeletal muscle just makes pyruvate for energy
