Penicillin, Cephalosporins, and Carbapenems

Question 1

Penicillin is scientifically known as

Answer 1

6-aminopenicillanic acid

Question 2

Mechanisms of Actions

Answer 2

Cell Wall Synthesis
Antimetabolites
DNA Replication
RNA Synthesis
Protein Synthesis
 -30S ribosome
 -50S ribosome

Question 3

The name of the structure of penicillin

Answer 3

“Penicillin Home”

Question 4

A broad spectrum penicillin

Answer 4

Ampicillin

Question 5

Destroys beta-lactam rings

Answer 5

beta-lactamase

Question 6

Outer protection of gram-positive bacteria

Answer 6

peptidoglycan cell wall

Question 7

Outer protection of gram-negative bacteria

Answer 7

outer membrane, periplasmic space

Question 8

Bacteria with this outer membrane are not effective to be used with penicillin

Answer 8

sterol-packed

Question 9

True or False:

Penicillin is bacteriocidal.

Answer 9

TRUE. Penicillin is bacteriocidal.

Question 10

A penicillin taken intravenously

Answer 10

Penicillin G

Question 11

A penicillin taken by mouth

Answer 11

Penicillin V

Question 12

The ability of the drug to bind to its receptor

Answer 12

Affinity

Question 13

What causes antibacterial resistance:

Answer 13

Destruction of antibiotic by beta-lactamase
Failure of antibiotic to penetrate to active site
Low affinity binding of antibiotic to PBPs

Question 14

Who discovered penicillin?

Answer 14

Alexander Fleming

Question 15

The main ring of penicillins

Answer 15

Thiazolidine ring

Question 16

Natural penicillin of Pen G

Answer 16

Penicillin notatum

Question 17

Natural penicillin of Pen V

Answer 17

Penicillin fulvum

Question 18

A bacteria named after methicillin

Answer 18

methicillin-resistant staphylococcus aureus (MRSA)

Question 19

MRSA means?

Answer 19

methicillin-resistant staphylococcus aureus

Question 20

An antibiotic taken after birth

Answer 20

ampicillin

Question 21

An antibiotic misused for toothache

Answer 21

amoxicillin

Question 22

Most used uridopenicillin

Answer 22

piperacillin

Question 23

Acidic form of clavulinate

Answer 23

clavulanic acid

Question 24

Protects beta-lactamase

Answer 24

Beta-lactamase inhibitors

Question 25

Beta-lactamase inhibitors are also known as?

Answer 25

Suicide drug

Question 26

1+1=1

Answer 26

Potentiation

Question 27

"Penicillin with an underground basement"

Answer 27

Cephalosporin

Question 28

Excellently penetrates through tissues

Answer 28

Cephalosporin

Question 29

A patient allergic to penicillin can take cephalosporin instead.

Answer 29

FALSE. Both have a similar structure.

Question 30

Main ring of cephalosporins

Answer 30

Dihydrothiazine ring

Question 31

Cephalosporins are excreted through?

Answer 31

Kidneys

Question 32

A prototype of all cephalosporins

Answer 32

Cefuroxime

Question 33

Cefuroxime is a what generation of drug

Answer 33

2nd generation

Question 34

Generation used against gram+ bacteria only

Answer 34

1st generation

Question 35

Generation used against gram+ bacteria and gram- except meningitis

Answer 35

2nd generation

Question 36

Generation used against gram- bacteria, less gram+, few against pseudomonas

Answer 36

3rd generation

Question 37

Generation used against gram+ staph. aureus, gram- pseudomonas

Answer 37

4th generation

Question 38

Generation used for targeted therapy

Answer 38

4th generation

Question 39

Cephalosporins are NOT effective against?

Answer 39

Listeria monocytogenes Enterococcus spp. Anaerobes

Question 40

Bacteria that can live without oxygen

Answer 40

Anaerobes

Question 41

Decrease of neutrophils

Answer 41

Neutropenia

Question 42

Rare adverse effects of penicillin

Answer 42

Neurologic | Renal

Question 43

Allergic reaction, cannot breath

Answer 43

Anaphylaxis

Question 44

Allergic reaction, itchiness

Answer 44

Urticaria

Question 45

Allergic reaction, blood

Answer 45

Hemolitic anemia

Question 46

Adverse reaction, misuse of drug, high dose, affects the kidneys

Answer 46

Hepatic dysfunction

Question 47

Causes platelet dysfunction

Answer 47

Cefuroxime

Question 48

Adverse effect of cefuroxime

Answer 48

Platelet dysfunction

Question 49

Imipenems

Answer 49

gram- anaerobes less pseudomonas active against antibacterial-resistant cephalosporin

Question 50

gram-, anaerobes, less of gram+, active against bacteria resistant cephalosporin

Answer 50

Meropenems

Question 51

Meropenem

Answer 51

``` gram- anaerobes less gram+ active against antibacterial-resistant cephalosporin for children ```

Question 52

gram-, anaerobes, less of gram+, active against bacteria resistant cephalosporin, for children

Answer 52

Meropenem

Question 53

Astreonam

Answer 53

gram- gram resistant to many antibiotics not for gram+ for allergic to penicillin and cephalosporin

Question 54

Used for patients allergic to penicillin and cephalosporin

Answer 54

Astreonam

Question 55

Astreonam is what type of antibiotic

Answer 55

Monobactam