CNS Drugs Flashcards
True or False:
Older sedative-hypnotic drugs are dose-dependent.
TRUE. More dose means more effect
This drug reduces anxiety, physically, emotionally, and cognitively.
Anxiolytic
This is given to people with general anxiety disorder and major depression.
Anxiolytic
calms down, relieve agitation
Sedative
mostly abused due to its euphoric effect
Sedatives
induce sleep and is given to people with insomnia
Hypnotics
has calming effect but does not induce sleep
Anxiolytic
reduces nervousness, excitability, and irritability without sleep
Sedative
produces drowsiness effect
Hypnotic
drugs which depress or slow down body functions
Sedative-hypnotics
Sedative-hypnotics are also referred to as?
Tranquilizers or sleeping pills
It calms down and promotes sleep
Sedative-hypnotic
True or False:
Tranquilizers and sleeping pills effect depends on its dosage.
TRUE. Tranquilizers and sleeping pills effect depends on its dosage.
High doses of sedative-hypnotics causes?
unconsciousness or death
This is a receptor antagonist, or an antidote, for benzodiazepine.
Flumazenil
controls excitability of neurons by binding to GABA A receptor
GABA
protein complex in the synapses of neurons
GABA A receptor
contains an ion channel that conducts chloride ions across neuronal cell membranes and two binding cites for GABA
GABA A receptor
controls GABA A
chloride ions
these are positive GABA A modulators
Sedative-hypnotics
they increase the ability of GABA to open the chloride ion channel
Sedative-hypnotics
Low doses of barbiturates and benzodiazepines
enhance the effect of GABA
High doses of barbiturates
open the ion channel
Barbiturates were first used in what year?
1903
GABA means?
gamma-aminobutyric acid
Barbiturates are:
- habit-forming
- very narrow theraputic index
- notorious enxyme inducers
- weak analgesic effects
- produce wide spectrum of effects
An ultra-short acting barbiturate used as an anesthesia
thiopental
Principal use of short-acting barbiturates
sleep-inducing hypnotics
