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AIA > Penicillin > Flashcards

Penicillin Flashcards

1
Q

Penicillin act by
A. Inhibition of protein synthesis
b. intefering cell wall synthesis
c. phagocytosis of bacteria

A

b. intefering cell wall synthesis

penicillin are bactericidal

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2
Q

Natural penicillin which is administered only oral route

A

pen v

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3
Q

Penicillinase-resistant penicillin include

a. pen v
b. methicillin
c. ampicillin

A

b. methicillin

including nafcillin, dicloxacillin, oxacillin

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4
Q

Flucloxacillin is effective in skin infx treatment. T/F?

A

T

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5
Q

Which of the following statement abt penicillin is false?

a. ticarcillin is resistant to beta-lactamase
b. penicillin are bacteriostatic
c. pen v via oral,IV,IM
d. all

A

d. all

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6
Q

Which of the following abt clavulanic acid is false?

a. it is beta lactamase inhibitor
b. has no antibacterial activity
c. bears a beta lactam ring
d. none

A

d. none

  • clavulanic acid is a potent inhibitor of beta lactamase
  • no intrinsic antibacterial activity by itself but prevents antibacterial drug being broken down by betalactamase
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7
Q

Most common side effect of ampicillin

a. diarrhea
b. renal failure
c. head ache
d. jaundice

A

a. diarrhea

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8
Q

Example of antistaphylococcal penicillin

a. pen g
b. nafcillin
c. procaine penicilline
d. none

A

b. nafcillin

penicillinase-resistant penicillin is not hydrolysed by staph penicillinase (betalactamase)

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9
Q

Which penicillin dont required dosage adjustment in renal failure?

a. piperacillin
b. nafcillin
c. ampicillin
d. none

A

b. naficillin

nafcillin and oxacillin are primarily metabolised by liver

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10
Q

Which dont hv antibacterial activity?

a. pen g
b. penicilloic acid
c. nafcillin

A

b. penicilloic acid

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11
Q

Which hv potential to cause interstitial nephritis?

a. methicillin
b. piperacillin
c. oxacillin
d. ampicillin

A

a. methicillin

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12
Q

Which is active against pseudomonas?

a. ticarcillin
b. dicloxacillin
c. pen g
d. ampicillin

A

a. ticarcillin

piperacillin and ticarcillin are antipseudomonal

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13
Q

bacterial resistance to penicillin occur due to

a. beta lactamase activity
b. decrease permeability to drug
c. altered PBP
d. all

A

d. all

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14
Q

What structural feature of penicillin is involved in its MOA?

a. disulfide bond
b. COOH
c. acyl side chain
d. beta lactam ring

A

d. beta lactam ring

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15
Q

Which is beta lactamase inhibitor?

a. clavulanic acid
b. nafcillin
c. meropenem

A

a. clavulanic acid

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16
Q

A penicillin preparation which is suitable for oral administration is

A. Benzathine Penicillin

B. Benzylpenicillin

C. Procaine benzylpenicillin

D. Phenoxymethylpenicillin

A

D. Phenoxymethylpenicillin

17
Q

Penicillinase-resistant penicillins include

A. benzylpenicillin

B. phenoxymethylpenicillin

C. cloxacillin

D. ampicillin

A

C. cloxacillin

18
Q

Co-amoxiclav is a:

A. penicillin-beta-lactamase inhibitor combinations

B. penicillin active against gram negative bacteria.

C. carbapenem group of antibiotic.

D. narrow spectrum penicillin.

A

A. penicillin-beta-lactamase inhibitor combinations

19
Q

Which statement about penicillins is FALSE

A. Penicillins cross CSF if the meninges are inflamed.

B. Benzylpenicillin is highly active against Streptococcus pneumoniae .

C. Procaine penicillin, given i.m. only.

D. penicillins do not cause neutropenia in high does given for longer than 10 days.

A

D. penicillins do not cause neutropenia in high does given for longer than 10 days.

20
Q

Which statement about penicillins is TRUE

A. Penicillins on high doses cause convulsions.

B. Benzylpenicillin is not effective for infections due to normal strains of Neisseria meningitidis

C. Phenoxymethylpenicillin is not resistant to gastric acid.

D. Penicillins are not effective against normal strains of gram positive bacteria.

A

A. Penicillins on high doses cause convulsions.

21
Q

Identification of methicillin-resistant Staphylococcus aureus (MRSA) in patients indicates:

A. the organisms are sensitive to flucloxacillin and cloxacillin

B. the organisms are sensitive to beta-lactam antibiotics

C. the organisns are resistant to flucloxacillin, cloxacillin, and other beta-lactam antibiotics

D. usual infection-control measures are satisfactory to manage the infections.

A

C. the organisns are resistant to flucloxacillin, cloxacillin, and other beta-lactam antibiotics

22
Q

Which statement about ampicillin is FALSE:

A. Ampicillin cause diarrhoea on oral administration.

B. Ampicillin may cause maculopapular rashes

C. Amoxycillin is better absorbed from gut than ampicillin.

D. Ampicillin is a cephalosporin group of antibiotic.

A

D. Ampicillin is a cephalosporin group of antibiotic.

23
Q

Ureidopenicillins are:

A. adapted from the ampicillin molecule, and effective against Pseudomonas aeruginosa

B. carboxypenicillins .

C. monobactam antibiotics.

D. beta-lactamase resistant penicillins.

A

A. adapted from the ampicillin molecule, and effective against Pseudomonas aeruginosa

24
Q 
Which one ofthe following drugs is an antipseudomonal penicillin?
A. Cephalexin
B. Cloxacillin
C. Piperacillin
D. Dicloxacillin
A

C. Piperacillin

Antipseudomonal penicillins

Carboxypenicillins
Carbenicillin
Ticracillin
Ureidopenicillins
Piperacillin
Mezlocillin
25
Q

Most common s/e of oral administration of ampicillin is

A

diarrhea

26
Q

Penicillin is effective against

a. neisseria meningitidis
b. neiserria gonorrhea
c. treponema pallidum
d. all

A

d. all

27
Q

Which is penicillinase-resistant penicillin?

a. amoxicillin
b. cloxacillin
c. ampicillin
d. pen g

A

b. cloxacillin

28
Q

Clavulanic acid added to ampicillin cause
a. increase effectiveness against g-ve
b.inhibit b lactamase
increase effectiveness against g+ve

A

b.inhibit b lactamase

29
Q

Which antibiotic is effective against pseudomonas?

a. methicillin
b. carbenicillin
c. oxacillin

A

b. carbenicillin

piperacillin,ticarcillin and carbenicillin is antipseudomonal

30
Q

Which has best g-ve spectrum?

a. methicillin
b. ampicillin
c. pen v

A

b. ampicillin

31
Q

B lactam antibiotics are

a. penicillin
b. imipenem
c. cephalo
d. all

A

d. all

32
Q

pen g combine with probenecid result in

a. increase excretion of probenecid in feces and perspiration
b. increase excretion of probenecid in urine
c. increase metabolism of pen g
d. decrease renal excretion of pen g

A

d. decrease renal excretion of pen g

Probenecid is sometimes used along with penicillin antibiotics (e.g., penicillin, ampicillin, nafcillin) to increase antibiotic blood levels. This increase makes the antibiotic work better at treating certain infections. Probenecid works by decreasing the kidneys’ ability to remove the antibiotic from the body.

33
Q

Clavulanic acid is combined with amoxicillin to

a. reduce risk of allergy
b. prolong amoxicillin half life
c. reduce severity of darrhea
d. extend amoxicillin antibacterial spectrum

A

d. extend amoxicillin antibacterial spectrum

Clavulanic acid is a beta-lactamase inhibitor that is frequently combined with Amoxicillin or Ticarcillin to fight antibiotic resistance by preventing their degradation by beta-lactamase enzymes, broadening their spectrum of susceptible bacterial infections

AIA (7 decks)

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