Anti TB Flashcards
NOT a side effect of isoniazid (INH): hepatotoxicity allergic reactions peripheral neuritis nephrotoxicity
nephrotoxicity
Decreases likelihood of resistance to other antituberculosis drugs: rifampin (Rimactane) ethambutol (Myambutol) streptomycin isoniazid (INH)
ethambutol (Myambutol)
Hepatotoxic given at normal doses for extended periods for treatment of tuberculosis: streptomycin para-aminosalicylic acid (PAS) isoniazid (INH) B & C
B & C
Mechanism of action: isoniazid (INH)
competitive inhibitor with PABA
mycolic acid synthesis inhibitor
inhibits RNA polymerase (binds to the polymerase.
blocks protein synthesis like chloramphenicol (Chloromycetin)
mycolic acid synthesis inhibitor
Mechanism of action: rifampin (Rimactane)
a. PABA competitor
b. mycolic acid synthesis
c. inhibits RNA synthesis by binding to DNA dependent RNA polymerase
d. none of the above
inhibits RNA synthesis by binding to DNA dependent RNA polymerase
Following oral administration, blood brain barrier prevents effective treatment of CNS tuberculosis:
a. rifampin (Rimactane) to
b. ethambutol (Myambutol)
c. isoniazid (INH)
d. streptomycin
d. streptomycin
Ethambutol (Myambutol) (in combination with isoniazid (INH)) exhibits adverse effects especially directed to this organ:
a. hepatic toxicity
b. nephrotoxicity
c. ocular toxicity
d. splenic toxicity
c. ocular toxicity
Most common side effect: optic neuritis associated with reduced visual acuity, usually reversible
Auditory deficits:
a. steptomycin
b. ethambutol (Myambutol)
c. both
d. neither
a.steptomycin
NOT an appropriate use for rifampin (Rimactane):
a. treatment of leprosy (with a sulfone)
b. treatment of meningococcal carriers
c. prophylaxis for exposure to H. influenzae
d. Pseudomonal bacteriostasis
d. Pseudomonal bacteriostasis
Minimum treatment duration for active TB
a. one to three months
b. six to nine months
c. for life
d. five years
b. six to nine months
should be satisfactory in uncomplicated tuberculosis; tubercular meningitis requires longer treatment (18 - 24 months)
Liver toxicity (hepatoxic)
a. isoniazid (INH)
b. rifampin (Rimactane)
c. both
d. neither
c.both
Isoniazid (INH)
a. tuberculostatic agent
b. neurotoxicity
c. well-absorbed from the GI tract
d. all of the above
d.all of the above
Antimycobacterial agent NOT absorbed orally:
a. isoniazid (INH)
b. streptomycin
c. rifampin (Rimactane)
d. ethambutol (Myambutol)
b.streptomycin
causing orange colored urine is
rifampicin
Which ATT has max CSF penetration?
a. ethambutol
b. streptomycin
c. INH
d. rifampicin
c. INH
Which can cause psychosis?
a. rifampicin
b. cycloserine
c. capreomycin
b. cycloserine
Which of the following antitubercular drug is NOT hepatotoxic??
Streptomycin
ATT most commonly implicated in causing peripheral neuropathy is:?
INH
INH induced peripheral neuropathy results from deficiency of vitamin:?
B6
Which of the following antitubercular drugs can be used in patients with hepatic dysfunction??
Streptomycin
Which ATT is implicated in transient memory loss?
AIsoniazid
BEthionamide
CPyrazinamide
DEthambutol
Isonoazid is known to cause mental abnormalities like euphoria, tansient memory loss, loss of senlf control and florid psychosis.
While treating patient of MDR-tuberculosis, which of the following drugs do you think will be more effective??
Clarithromycin
Amikacin
Amikacin is known to be most resistant to inactivating enzymes and is therefore used as a second line antitubercular drug used in MDR-TB.
Isoniazid is metabolized by acetylation reactions which is prone to genetic polymorphism. Patients identified as fast-acetylators are more prone to develop which of the following effects??
Your-Option:-Failure of therapy
Right-Option:-Hepatotoxicity
In fast acetylators the metabolism occurs very fast, so accumulation of the metabolite acetyl hydrazine occurs leading to hepatotoxicity. So fast acetylators are prone to hepatotoxicity by isoniazid. Peripheral neuropathy is seen in slow acetylators where there is accumulation of the parent drug.
One of the first line anti-tubercular therapy drug is given as a prodrug. In some of the cases resistance might develop as a result of failure of activation of the drug. Spot the drug.?
Your-Option:-Rifampicin
Right-Option:-Isoniazid
KatG gene mutation is the most common cause of resistance to Isoniazid. The gene codes for catalase-peroxidase that activates isoniazid. The resistance is due to failure of activation of the prodrug.
All of the drugs for TB listed below are bactericidal, EXCEPT:?
Your-Option:-Pyrazinamide
Right-Option:-Ethambutol
Ethambutol is the Bacteriostatic
Hypothyroidism is caused by which of the following anti-tubercular drug??
Ethionamide
Arthralgia is commonly caused by which ATT drug??
Pyrazinamide
