Anti TB

Question 1

NOT a side effect of isoniazid (INH):
   hepatotoxicity
  allergic reactions
peripheral neuritis
  nephrotoxicity

Answer 1

nephrotoxicity

Question 2

Decreases likelihood of resistance to other antituberculosis drugs:
  rifampin (Rimactane)
  ethambutol (Myambutol)
   streptomycin
  isoniazid (INH)

Answer 2

ethambutol (Myambutol)

Question 3

Hepatotoxic given at normal doses for extended periods for treatment of tuberculosis:
   streptomycin
   para-aminosalicylic acid (PAS)
  isoniazid (INH)
  B & C

Answer 3

B & C

Question 4

Mechanism of action: isoniazid (INH)
competitive inhibitor with PABA
mycolic acid synthesis inhibitor
inhibits RNA polymerase (binds to the polymerase.
blocks protein synthesis like chloramphenicol (Chloromycetin)

Answer 4

mycolic acid synthesis inhibitor

Question 5

Mechanism of action: rifampin (Rimactane)

a. PABA competitor
b. mycolic acid synthesis
c. inhibits RNA synthesis by binding to DNA dependent RNA polymerase
d. none of the above

Answer 5

inhibits RNA synthesis by binding to DNA dependent RNA polymerase

Question 6

Following oral administration, blood brain barrier prevents effective treatment of CNS tuberculosis:

a. rifampin (Rimactane) to
b. ethambutol (Myambutol)
c. isoniazid (INH)
d. streptomycin

Answer 6

d. streptomycin

Question 7

Ethambutol (Myambutol) (in combination with isoniazid (INH)) exhibits adverse effects especially directed to this organ:

a. hepatic toxicity
b. nephrotoxicity
c. ocular toxicity
d. splenic toxicity

Answer 7

c. ocular toxicity

Most common side effect: optic neuritis associated with reduced visual acuity, usually reversible

Question 8

Auditory deficits:

a. steptomycin
b. ethambutol (Myambutol)
c. both
d. neither

Answer 8

a.steptomycin

Question 9

NOT an appropriate use for rifampin (Rimactane):

a. treatment of leprosy (with a sulfone)
b. treatment of meningococcal carriers
c. prophylaxis for exposure to H. influenzae
d. Pseudomonal bacteriostasis

Answer 9

d. Pseudomonal bacteriostasis

Question 10

Minimum treatment duration for active TB

a. one to three months
b. six to nine months
c. for life
d. five years

Answer 10

b. six to nine months

should be satisfactory in uncomplicated tuberculosis; tubercular meningitis requires longer treatment (18 - 24 months)

Question 11

Liver toxicity (hepatoxic)

a. isoniazid (INH)
b. rifampin (Rimactane)
c. both
d. neither

Answer 11

c.both

Question 12

Isoniazid (INH)

a. tuberculostatic agent
b. neurotoxicity
c. well-absorbed from the GI tract
d. all of the above

Answer 12

d.all of the above

Question 13

Antimycobacterial agent NOT absorbed orally:

a. isoniazid (INH)
b. streptomycin
c. rifampin (Rimactane)
d. ethambutol (Myambutol)

Answer 13

b.streptomycin

Question 14

causing orange colored urine is

Answer 14

rifampicin

Question 15

Which ATT has max CSF penetration?

a. ethambutol
b. streptomycin
c. INH
d. rifampicin

Answer 15

c. INH

Question 16

Which can cause psychosis?

a. rifampicin
b. cycloserine
c. capreomycin

Answer 16

b. cycloserine

Question 17

Which of the following antitubercular drug is NOT hepatotoxic??

Answer 17

Streptomycin

Question 18

ATT most commonly implicated in causing peripheral neuropathy is:?

Answer 18

INH

Question 19

INH induced peripheral neuropathy results from deficiency of vitamin:?

Answer 19

B6

Question 20

Which of the following antitubercular drugs can be used in patients with hepatic dysfunction??

Answer 20

Streptomycin

Question 21

Which ATT is implicated in transient memory loss?

AIsoniazid
BEthionamide
CPyrazinamide
DEthambutol

Answer 21

Isonoazid is known to cause mental abnormalities like euphoria, tansient memory loss, loss of senlf control and florid psychosis.

Question 22

While treating patient of MDR-tuberculosis, which of the following drugs do you think will be more effective??
Clarithromycin
Amikacin

Answer 22

Amikacin is known to be most resistant to inactivating enzymes and is therefore used as a second line antitubercular drug used in MDR-TB.

Question 23

Isoniazid is metabolized by acetylation reactions which is prone to genetic polymorphism. Patients identified as fast-acetylators are more prone to develop which of the following effects??
Your-Option:-Failure of therapy
Right-Option:-Hepatotoxicity

Answer 23

In fast acetylators the metabolism occurs very fast, so accumulation of the metabolite acetyl hydrazine occurs leading to hepatotoxicity. So fast acetylators are prone to hepatotoxicity by isoniazid. Peripheral neuropathy is seen in slow acetylators where there is accumulation of the parent drug.

Question 24

One of the first line anti-tubercular therapy drug is given as a prodrug. In some of the cases resistance might develop as a result of failure of activation of the drug. Spot the drug.?
Your-Option:-Rifampicin
Right-Option:-Isoniazid

Answer 24

KatG gene mutation is the most common cause of resistance to Isoniazid. The gene codes for catalase-peroxidase that activates isoniazid. The resistance is due to failure of activation of the prodrug.

Question 25

All of the drugs for TB listed below are bactericidal, EXCEPT:?
Your-Option:-Pyrazinamide
Right-Option:-Ethambutol

Answer 25

Ethambutol is the Bacteriostatic

Question 26

Hypothyroidism is caused by which of the following anti-tubercular drug??

Answer 26

Ethionamide

Question 27

Arthralgia is commonly caused by which ATT drug??

Answer 27

Pyrazinamide