antiviral

Question 1

Which of the following drugs inhibit herpes viruses?

a) Amantadine
b) Acyclovir
c) Oseltamivir
d) Azidothymidine

Answer 1

b) Acyclovir

Question 2

Which point in the replication cycle appears most easily blocked by antivirals?

a) Virus absorption
b) Virus penetration
c) Virus RNA and DNA replication
d) Exit of viruses from the cell

Answer 2

c) Virus RNA and DNA replication

Experience has shown that nucleoside and nucleotide analogues are the most easily discovered antivirals especially for HHV and HIV.

Question 3

Choose the following correct combination of drug and virus:

a) Amantadine versus influenza B
b) Daclatasvir versus hepatitis C
c) Zidovudine versus hepatitis B
d) Saquinavir versus influenza A

Answer 3

b) Daclatasvir versus hepatitis C

Question 4

1. Which of the following antiviral drug is used to treat influenza A?
   a) Dextran sulfate
   b) Amantadine
   c) Ganciclovir
   d) Cidofovir

Answer 4

Answer: b
Explanation: Amantadine is an antiviral drug that is used to treat the infection from influenza virus. It is used to treat and prevent the respiratory infections and symptoms of Parkinson’s disease.

Question 5

2. Which of the following is used to treat eye infection?
   a) Rimantadine
   b) Ganciclovir
   c) TFT

Answer 5

Answer: c
Explanation: Trifluoro thymidine (TFT) is used to treat the infection of the eye with the herpes simplex virus (HSV). It is also called as trifluridine and its eye drops are used to keratitis and keratoconjunctivitis. It may irritate eyelids.

Question 6

3. Which of the following is not used in the HIV-1 treatment?
   a) Delavirdine
   b) Zidovudine
   c) Rimantadine
   d) Stavudine

Answer 6

Answer: c
Explanation: Rimantadine is not used in the treatment of infection of HIV-1. It is used to treat the infection of influenza A virus. Delavirdine, zidovudine, stavudine, etc. are the antiviral drugs used for the treatment of HIV-1 infection.

Question 7

4. Which of the following is used to treat CMV infections?
   a) Foscarnet
   b) Saquinavir
   c) Ritonavir
   d) Nelfinavir

Answer 7

Answer: a
Explanation: Foscarnet is an antiviral drug that is used for the treatment of cytomegalovirus infections. It is also used to control eye infections in person with AIDS. Saquinavir, ritonavir, nelfinavir, etc. are used in HIV treatment.

Question 8

5. Which of the following is used to treat poxvirus?
   a) Zalcitabine
   b) Cidofovir
   c) Penciclovir
   d) Zanamivir

Answer 8

Answer: b
Explanation: Cidofovir is an antiviral substance used to treat the infection from poxvirus (VZV). It is also used to treat the infection of the retina of an eye. The esters of cidofovir reduce the renal toxicity that is used for poxvirus treatment.

Question 9

6. Which of the following is used to treat genital herpes infections?
   a) Penciclovir
   b) Pleconaril
   c) Oseltamivir
   d) Efavirenz

Answer 9

Answer: a
Explanation: Penciclovir is a licensed antiviral drug that is used to treat the genital infections of the herpes virus. It targets the DNA polymerase of the virus and does not allow it to replicate the virus.

Question 10

7. Which of the following is easily blocked by antivirals?
   a) Virus penetration
   b) Nucleic acid replication
   c) Virus absorption
   d) Removal of the virus from the cell

Answer 10

Answer: b
Explanation: Nucleic acid replication, that is DNA or RNA replication is easily blocked by antiviral compounds because nucleoside and nucleotide analogs are easily discovered antivirals.

Question 11

10. The mutations in the M2 gene is responsible for drug resistance in influenza A virus.
    a) True
    b) False

Answer 11

Answer: a
Explanation: The mutations in the M2 gene is responsible for drug resistance in the influenza A virus. The influenza A virus gets resistant to drugs such as amantadine, zanamivir, etc.

Question 12

the anti HIV drug that also effective in chronic Hepatitis b is

a. nelfinavir
b. zidovudine
c. efavirenz
d. lamivudine

Answer 12

d. lamivudine

used alone or combine w IFN-a; longer half life in HBV than in HIV

Question 13

Viral HIV integrase inhibitor is

a. maraviroc
b. raltegravir
c. enfluvirtide
d. zidovudine

Answer 13

b. raltegravir

Question 14

which PI has boosting effect

a. tenovir
b. amprenavir
c. ritonavir
d. nelfinavir

Answer 14

c. ritonavir

in low dose can combine w other PI to increase their plasma conc

Question 15

avian influenza treated by

a. amantadine
b. ribavarin
c. cidofovir
d. oseltamivir

Answer 15

d. oseltamivir

DOC for avian and swine(influenza b)