antifungal

Question 1

Antifungal polyene macrolide that preferentially binds to fungal ergosterol which alters cellular permeability.
  ?    ketoconazole
  ?    amphotericin B
  ?    flucytosine
  ?    grisefulvin
  ?    clotrimazole

Answer 1

amphotericin B

Question 2

An azole most commonly used for topical treatment of candidiasis:
  ?    amphotericin B
  ?    clotrimazole
  ?    griseofulvin
  ?    flucytosine
  ?    none of the above

Answer 2

clotrimazole

Question 3

Polyene macrolide only used topically, due to systemic toxicity; active against most Candida species--most commonly used for suppression of local candidal infection.
  ?    miconazole
  ?    terbinafine
\:-)  nystatin
  ?    fluconazole
  ?    flucytosine

Answer 3

nystatin

Question 4

Inhibition of fungal squalene epoxidase is this antifungal drug's mechanism of action:
  ?    ketoconazole
  ?    fluconazole
  ?    terbinafine
  ?    nystatin
  ?    A & B

Answer 4

terbinafine

Question 5

Given by i.v. administration, the drug of choice for nearly all life-threatening mycotic infections--usually used as the initial induction regimen
  ?    ketoconazole
  ?    itraconazole
  ?    flucytosine
  ?    amphotericin B
  ?    nystatin

Answer 5

amphotericin B

broad-spectrum agent, but toxic

Question 6

Topical allylamine(s) used for treating tinea cruris and tinea corporis:
  ?    terbinafine
  ?    naftifine
\:-)  both
  ?    neither

Answer 6

both

Question 7

only topically used antifungal

Answer 7

clotrimazole

Question 8

what is allylamines MOA

Answer 8

inhibit ergosterol synthesis via squalene epoxidase

Question 9

which is not echinocandin

a. caspofungin
b. anidulafungin
c. itraconazole

Answer 9

c.itraconazole

Question 10

terbinafine is class antifungal

Answer 10

allylamine

Question 11

topical antifungal used for dermatophytes

Answer 11

tolfanate