Peds obstructive disorders, tieman 12/9 Flashcards
definition cholestasis
systemic retntion biliary constituents as result failure to form or flow bile
intrahepatic cholestasis lab results
elevated transaminases and unconj bili
what can cause intrahepatic cholestasis
failure of formation of bile in hepatocyte or obstructive process confined to intrahepatic bile duct
extrahepatic cholestasis
obstructive process of extrahepatic bile ducts
lab results with extrahepatic cholestasis
elevated AP, GGTP, conj bili
what is neonatal obstructive jaundice
any newborn presenting or persisting after 14 days
lab results of neonatal obstructive jaundice
elevated conj bili, AP, GGTP
acholic stools sometimes
most common causes neonatal obstructive jaundice
biliary atresia
less common: congenital biliary tract anomalies, choledochal cysts and infections
biliary atrestia
post natal destruction of EH bile bile ducts with resultant injury and fibrosis of IH bile ducts
what are associations with biliary atresia
extrahepatic anomalies
most common cause hepatic death and reason for liver transplantation in children
F>M
how is biliary atresia Dx
lab, US, MRC and liver bx
Tx biliary atresia
porto-enterostomy
better if done at <60 days age
what disease has choledochal cysts
type V intrahepatic
Caroli’s disease
majority choledochal cysts are found at what age
<10 y.o
presentation choledochal cysts
obstructive jaundice, acholic stools, pruritis, abd pain, and/or fever
