Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Year2 GI Exam II > drugs for GI infections I > Flashcards

drugs for GI infections I Flashcards

1
Q

What are the fluoroquinolones

A

Ciprofloxacin

Levofloxacin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what are the antiprotozoals

A

metronidazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what other antibiotics are available for GI infections

A

vancomycin, bactrim (trimethoprim-sulfamethoxazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

definition of diarrhea

acure, persisten chronic

A

> 3 unformed stools/day

acute 30 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what viruses cause diarrhea

A

noro and rota

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what bacteria cause diarrhea

A

salmonella, campylobacter, shigella, EHEC, vibrio, yersinia, EAEC, ETEC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what protozoa can cause diarrhea

A

cryptosporidium, giardia, cyclospora, entamoeba, others

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what pathogens can cause dysentery

A

shigella, salmonella, campylobacter, EHEC, yersinia and C difficile

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what do you test for with bloody diarrhea and no fever or HUS

A

shiga toxin and EHEC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

bloody diarrhea with recent immigration from tropical Africa, Asia or Latin Aerica

A

entamoeba histolytica

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what bloody diarrhea is assoc with shellfish

A

vibrio

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

general approach to Tx of infectious diarrhea

A

prevention dehydration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Tx protocol for mild-moderate dehydration

A

oral rehydration therapy, superior to administratino of IV fluids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

necesary compounds in oral rehydration therapy

A

carbs (glucose), Na, K, cl and water

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Indiscriminant se of antimicrobials leads to increased risk of

A

antimicrobial Resistance, prolonged shedding of certain pathogens, Salmonella, C difficile
Side effects
superinfection after destruction of normal flora

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what is rec antibiotic for mild to moderate travelers diarrhea

A

loperamide of bismuth subsalicylate alone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

if travelers diarrhea is associated with fever or bloody stools, self tx with what antibiotics for how long

A

any of the floxacins for 3 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

what drug is used to tx noninvasive strains of E coli

A

rifaximin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

what is Tx for quinolone R campylobacter

A

azithromycin

20
Q

what antibiiotic use is assoc with C difficile

A

clindamycin, ampicilin, cephalosporins, fluoroquinolones, PPIs

21
Q

hish risk groups C diff

A

elderly, debilitated, cancer, surgical

22
Q

Tx options for C diff

A

metronidazole (PO or IV), vancomycin PO, fidazomicin

23
Q

Vancomycin is preffered for when in C diff

A

severe infection

otherwise use metronidazole

24
Q

how is vanco administered

A

PO

25
Q

Tx campylobacteriosis

A

erythromcyin

26
Q

if Diarrhea lasts longer than 7-10 days, most likley?

A

parasitic, giardia

27
Q

Tx giardia

A

metronidazole

28
Q

when is antibiotic Tx not recommended for diarrhea

A

EHEC, salmonella

29
Q

why do not use antibiotics with salmonella

A

increase fecal shedding of pathogens and associated with prolonged carriage and relapse, does not reduce diarrhea

30
Q

MOA idoquinol antiprotozoal

A

unknown, only effective on luminal organisms

31
Q

therapeutic use idoquinol

A

adjunt to metronisazole in amebiasis

32
Q

Adverse effects idoquinol

A

diarrhea, anorexia, nausea, comiting, abdominal pain, HA, rash, pruritis
may increase protein bound serum iodine
use caution in those with optic neuropathy, renal or thyroid disease or nonamebic hepatic disease

33
Q

MOA nitazoxanide

A

inhibits pyruvate-ferredoxin oxidoreductase pathway

34
Q

therapeutic use nitazoxanide

A

cryptosporidium

alternative to metronidazole in giardia

35
Q

MOA paromomycin

A

interferes with bacterial protein synthesis by binding 30S ribosomal subunits
only luminal organisms

36
Q

therapeutic use paromomycin

A

Tx acute and chronic intestinal amebiasis

off label cryptosporidium

37
Q

adverse effects paromomycin

A

occasional abdominal distress and diarrea

may accumulate with renal insufficiency

38
Q

MOA albendazole

A

antihelminthic

though to inhibit microtubule synthesis

39
Q

wha tincreases absorption albendazole

A

fatty meals for tissue parasites

empty stomach for intraluminal parasites

40
Q

therapeutic use albendazole

A

hydatid disease
cysticercosis
pinworm and hookworm infections: ascariasis, trichuriasis, strongyloides

41
Q

therapeutic use rifaximin

A

prevention hepatic encephalopathy
travelers diarrhea from EHEC
off label IBS and refractory C difficile

42
Q

MOA fidaxomicin

A

inhibits RNA polymerase resulting in inhibition protein synthesis causing cell death

43
Q

PK of fidaxomicin

A

GI tract, undergoes intestinal hydrolysis to a less active metabolie

44
Q

therapeutic use fidaxomicin

A

C difficile infection

45
Q

adverse effects fidaxomicin

A

nausea, abdominal pain, vomiting

HS reacitons have been reported

Year2 GI Exam II (18 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions