Pedia Allergology & Immunology Flashcards
Predominant cells in early-phase IgE response
Mast cells
Predominant cells in late-phase response of IgE-mediated immune response
Neutrophils and eosinophils
Tissue remodeling leads to irreversible changes in target organs
Chronic allergic disease
Allergen immunotherapy is contraindicated in patients taking in what type of medication?
Beta-blockers
Pale mucosa, clear mucoid nasal discharge, allergic salute, rabbit nose
Allergic rhinitis
Asplenic patients are susceptible to infection by these bacteria
Encapsulated bacteria: Hib Strep pneumoniae N. meningitidis Group B strep Klebsiella pneumoniae
Mucosa assoc lymphoid tissues (MALT):
Pe-L-T-S Peyer's patches (SI) Lymphoid follicles (appendix) Tonsils Submucosal lymphoid tissues (upper airways/bronchi)
First line of defense against neonatal herpes virus infection
Natural killer cells
NK cells bind and trigger release of this protein that create spores on cell membranes of target cells resulting in lysis
Cytolysin
Presents with recurrent bacterial infections with a lack of pus formation
Leukocyte adhesion deficiency
Rare childhood AR disorder presenting with disordered coalescence of lysosomal granules leading to decrease neutrophil chemotaxis
Chédiak-Higashi Syndrome
Largest immunoglobulin with the earliest Ab in response to an Ag
IgM
Most abundant Ig and only one that can traverse the placenta
IgG
Major Ig in breast milk
IgA
Basis of tissue compatibility in recipient-donor screening
Human leukocyte antigens (MHC)
Type I, II, III or IV
Anaphylaxis
Type I
Type I, II, III or IV
Good pasture’s syndrome
Type II
Type I, II, III or IV
Blood transfusion reactions
Type II
Type I, II, III or IV
Stevens-Johnson syndrome
Type III
Type I, II, III or IV
SLE
Type III
Type I, II, III or IV
PPD test
Type IV
Type I, II, III or IV
Leprosy
Type IV
Type I, II, III or IV
Syphilis
Type IV
B-cell immunodeficiency disorder
X-linked agammaglobilinemia (Bruton’s disease)
Healthy until 6months due to maternal Ab
Recurrent ear infx, bronchitis or pneumococcal pneumonia, and/or dermatitis
Tx: gamma globulin IM once a month
T-cell immunodeficiency disorder
Congenital thymic aplasia (DiGeorge syndrome)
Increased susceptibility to viral, fungal, and protozoan infections
Tx: fetal thymus transplant as early as pos
What other abnormalities are assoc with DiGeorge syndrome?
CATCH22 Cardiac abnormalities Abnormal facies Thymic hypoplasia Cleft palate Hypocalcemia 22q11.2 chromosomal deletion
50% of SCID is due to this deficiency
Adenosine deaminase
X-linked recessive Immunodeficiency with thrombocytopenia and eczema
Wicket-Aldrich syndrome
TIE WASP
Thrombocytopenia Immunodeficiency Eczema Wiskott-Aldrich Syndrome Small defective Platelets
Often have prolonged bleeding from circumcision site or bloody diarrhea during infancy
Wiskott-Aldrich syndrome
