Pedia Allergology & Immunology

Question 1

Predominant cells in early-phase IgE response

Answer 1

Mast cells

Question 2

Predominant cells in late-phase response of IgE-mediated immune response

Answer 2

Neutrophils and eosinophils

Question 3

Tissue remodeling leads to irreversible changes in target organs

Answer 3

Chronic allergic disease

Question 4

Allergen immunotherapy is contraindicated in patients taking in what type of medication?

Answer 4

Beta-blockers

Question 5

Pale mucosa, clear mucoid nasal discharge, allergic salute, rabbit nose

Answer 5

Allergic rhinitis

Question 6

Asplenic patients are susceptible to infection by these bacteria

Answer 6

Encapsulated bacteria:
Hib
Strep pneumoniae
N. meningitidis
Group B strep
Klebsiella pneumoniae

Question 7

Mucosa assoc lymphoid tissues (MALT):

Answer 7

Pe-L-T-S
Peyer's patches (SI)
Lymphoid follicles (appendix)
Tonsils
Submucosal lymphoid tissues (upper airways/bronchi)

Question 8

First line of defense against neonatal herpes virus infection

Answer 8

Natural killer cells

Question 9

NK cells bind and trigger release of this protein that create spores on cell membranes of target cells resulting in lysis

Answer 9

Cytolysin

Question 10

Presents with recurrent bacterial infections with a lack of pus formation

Answer 10

Leukocyte adhesion deficiency

Question 11

Rare childhood AR disorder presenting with disordered coalescence of lysosomal granules leading to decrease neutrophil chemotaxis

Answer 11

Chédiak-Higashi Syndrome

Question 12

Largest immunoglobulin with the earliest Ab in response to an Ag

Answer 12

IgM

Question 13

Most abundant Ig and only one that can traverse the placenta

Answer 13

IgG

Question 14

Major Ig in breast milk

Answer 14

IgA

Question 15

Basis of tissue compatibility in recipient-donor screening

Answer 15

Human leukocyte antigens (MHC)

Question 16

Type I, II, III or IV

Anaphylaxis

Answer 16

Type I

Question 17

Type I, II, III or IV

Good pasture’s syndrome

Answer 17

Type II

Question 18

Type I, II, III or IV

Blood transfusion reactions

Answer 18

Type II

Question 19

Type I, II, III or IV

Stevens-Johnson syndrome

Answer 19

Type III

Question 20

Type I, II, III or IV

SLE

Answer 20

Type III

Question 21

Type I, II, III or IV

PPD test

Answer 21

Type IV

Question 22

Type I, II, III or IV

Leprosy

Answer 22

Type IV

Question 23

Type I, II, III or IV

Syphilis

Answer 23

Type IV

Question 24

B-cell immunodeficiency disorder

Answer 24

X-linked agammaglobilinemia (Bruton’s disease)

Healthy until 6months due to maternal Ab

Recurrent ear infx, bronchitis or pneumococcal pneumonia, and/or dermatitis
Tx: gamma globulin IM once a month

Question 25

T-cell immunodeficiency disorder

Answer 25

Congenital thymic aplasia (DiGeorge syndrome) Increased susceptibility to viral, fungal, and protozoan infections Tx: fetal thymus transplant as early as pos

Question 26

What other abnormalities are assoc with DiGeorge syndrome?

Answer 26

``` CATCH22 Cardiac abnormalities Abnormal facies Thymic hypoplasia Cleft palate Hypocalcemia 22q11.2 chromosomal deletion ```

Question 27

50% of SCID is due to this deficiency

Answer 27

Adenosine deaminase

Question 28

X-linked recessive Immunodeficiency with thrombocytopenia and eczema

Answer 28

Wicket-Aldrich syndrome TIE WASP ``` Thrombocytopenia Immunodeficiency Eczema Wiskott-Aldrich Syndrome Small defective Platelets ```

Question 29

Often have prolonged bleeding from circumcision site or bloody diarrhea during infancy

Answer 29

Wiskott-Aldrich syndrome