Pathophys II- Plasma cell disorders

Question 1

Plasma cell disorder characterized by

Answer 1

Monoclonlal Ig in blood

Question 2

Ig are also called

Answer 2

Paraproteins

Question 3

Ig in blood are also called

Answer 3

M proteins

Question 4

Of all Plasma cell disorders, which is 62% of cases?

Answer 4

MGUS

Monoclonal Gamopathy of Undetermined Significance

Question 5

MM is __ of all plasma cell disorders

Answer 5

18%

Question 6

Is MM a leukemia?

Answer 6

No

Question 7

Why MM is not a leukemia?

Answer 7

Bcs the plasma cells stay in marrow

We wont see them in the periphery

Question 8

Ig deposition disease example

Answer 8

Primary amyloidosis

Question 9

Along with SPEP we will also use

Answer 9

Immunofixation

Question 10

Which Ig is more common in MM?

Answer 10

IgG > IgA

Question 11

Clinical features of MM may be remembered using

Answer 11

CRAB

hyperCalcemia
Renal involvment
Anemia
Bone lytic lesions

Question 12

Peripheral blood smear in MM will show

Answer 12

Rouleaux formation

Question 13

MGUS

Answer 13

Monoclonal Gamopathy of Uncertain Significance

Question 14

What will we see in MGUS

Answer 14

Stable M-protein at low conc. over time

Question 15

Describe how we can get to PCL from

Answer 15

MGUS→SMM→MM→PCL

Question 16

Smoldering myeloma criteria

Answer 16

Serum M-protein > 30 g/L
Bone marrow plasma cell > 10%
No end organ damage

Question 17

Managment of Smoldering myeloma

Answer 17

Nothing

Surveillance

Question 18

MM=

Answer 18

Uncontrolled proliferation og Ig secreting plasma cells

Question 19

Ig in MM

Answer 19

IgG>IgA

Question 20

MM affects

Answer 20

Over 65 years

Question 21

Can we cure MM?

Answer 21

No

Question 22

MM criteria

Answer 22

Serum M-protein > 30 g/L
Bone marrow plasma cell > 10%
CRAB

Question 23

Typical immunological markers

Answer 23

CD38
CD56
CD138

Question 24

Which cytogenetical abnormality in MM resist therapy?

Answer 24

Abnormality of Chr. 11 and 13

Question 25

Why we will se anemia in MM?

Answer 25

Clonal PC proliferation decrease erythropoiesis

Question 26

ESR in MM

Answer 26

↑

Question 27

Stage 1 MM

Answer 27

B2-microglobulin < 35 mg/L

Question 28

Stage 2 MM

Answer 28

B2-microglobulin 35-55 mg/L

Question 29

0What can we find in urine of MM patient? (name)

Answer 29

Bens-Jones proteinuria

Question 30

B cell lymphoma with high levels of monoclnal IgM=

Answer 30

Walderstrom’s Macroglobulinemia