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S.N Pathophys final > Pathophys II- Hematopoiesis+Anemia > Flashcards

Pathophys II- Hematopoiesis+Anemia Flashcards

1
Q

Male RBC count

A

4.5-5.9 T/L

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2
Q

Female RBC count

A

4-5.2 T/L

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3
Q

Leukocyte count

A

4-10 G/L

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4
Q

Neut.

A

60-80%

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5
Q

Lymph.

A

20-40%

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6
Q

Mono.

A

2-6%

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7
Q

Eos.

A

1-4%

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8
Q

Baso.

A

0-1%

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9
Q

RBC diameter

A

6-8 micro meter

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10
Q

PLT count

A

150-400 G/L

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11
Q

PLT survival duration

A

8-10 days

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12
Q

Which IL is hematopoiesis gtowth factor?

A

IL-6

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13
Q

Normal bone marrow composition

A

Granulocytes and precursor- 60%
Erythroid precursor- 20%
Lymp. and mono.- 10%

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14
Q

How to recognize monocyte?

A

Very big

Bean shaped nucleus

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15
Q

As cell diferentiate (5)

A
  1. Cell size ↓
  2. Nucleus/Cytoplasm ratio ↓
  3. Nuclear chromation gets denser
  4. Basophilic color of cytoplasm ↓
  5. Number of nucleoli ↓
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16
Q

Important feature of Blast cell

A

Doesnt have granulocytes

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17
Q

Myeloblast to neut. pathway (6)

A 
Myeloblast
Promyelocyte
Myelocyte
Metamyelocyte
Band cell
Segmented cell
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18
Q

Name of RBC before it looses his nucleus

A

Orthochromatic normoblast

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19
Q

RBC pathway (6)

A 
Proerythroblast
Basophilic erythroblast
Polychromatic erythroblast
Orthochromatic erythroblast
Reticulocyte
Erythroblast
20
Q

Why male have more RBC?

A

Testosteron → EPO↑

21
Q

Medical term describing RBC with unequal size

A

Anisocytosis

22
Q

Normal % of reticulocytes in the blood

A

1-2%

23
Q

תא דם אדום בצורת קיפוד

A

Echinocyte (Burr cell)

24
Q

When will we see echinocytes?

A

Altered lipid memb
Artifact
Uremia

25
Q

RBC with nuclear remmnatn=

A

Howell Jolly body

26
Q

When will we see Spherocytes?

A

Hereditary spherocytosis

Immune Hemolytic Anemia

27
Q

B12 absorbtion

A

Parietlal cells in stomach secrete Intrinsic factors

28
Q

B12 absorbtion location

A

Terminal ileum

29
Q

Define Pernicios anemia

A

Gastritis with production of autoantibodies against Parietal cells or against Intrinsic factors

30
Q

When will Haptoglobin level decrease

A

When it will bind free Hemoglobin

31
Q

What is Hepcidin?

A

Acute phase reactant

32
Q

Hepcidin mechanism

A

Binds ferroportin

Decreases iron release from MPH

33
Q

Why PLT↑ in inflammatory process?

A

IL-6 acts on liver
Release TPO
Increases PLT

34
Q

Why Ferritin↑ in inflammatory process?

A

Acute phase reactant

35
Q

How does alcohol effects PLT?

A

Decrease production of TPO bcd of liver damage

36
Q

Why monocytes ↑ in alcoholic patients?

A

Common alteration

37
Q

Where is B12 stored?

A

Liver

38
Q

Why B12↑ in liver damage?

A

B12 is normally stored in liver

39
Q

Why MCV↑ in alcohol induced anemia?

A

Decreased folate levels leads to decreased DNA synthesis

40
Q

Spleen was removed. What will happen to PLT?

A

↑

41
Q

RBC in periphery with a nucleus=

A

Orthochromatic normoblasts

42
Q

What can trigger sickle cell disease?

A

Inflammatory process

43
Q

Explenation for WBC↑ in sickle cell disease?

A

Microclots causing tissue damage

44
Q

Tongue smooth shiny sensitive also called=

A

Hunter glossitis

45
Q

Hunter glossitis is seen in what disease?

A

B12/Folate deficiency

46
Q

Bone ,arrow smear of pernicious anemia patient will show us

A

Howell Jolly bosied

Megaloblasts

S.N Pathophys final (11 decks)

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