Pathophys II- Hematopoiesis+Anemia

Question 1

Male RBC count

Answer 1

4.5-5.9 T/L

Question 2

Female RBC count

Answer 2

4-5.2 T/L

Question 3

Leukocyte count

Answer 3

4-10 G/L

Question 4

Neut.

Answer 4

60-80%

Question 5

Lymph.

Answer 5

20-40%

Question 6

Mono.

Answer 6

2-6%

Question 7

Eos.

Answer 7

1-4%

Question 8

Baso.

Answer 8

0-1%

Question 9

RBC diameter

Answer 9

6-8 micro meter

Question 10

PLT count

Answer 10

150-400 G/L

Question 11

PLT survival duration

Answer 11

8-10 days

Question 12

Which IL is hematopoiesis gtowth factor?

Answer 12

IL-6

Question 13

Normal bone marrow composition

Answer 13

Granulocytes and precursor- 60%
Erythroid precursor- 20%
Lymp. and mono.- 10%

Question 14

How to recognize monocyte?

Answer 14

Very big

Bean shaped nucleus

Question 15

As cell diferentiate (5)

Answer 15

1. Cell size ↓
2. Nucleus/Cytoplasm ratio ↓
3. Nuclear chromation gets denser
4. Basophilic color of cytoplasm ↓
5. Number of nucleoli ↓

Question 16

Important feature of Blast cell

Answer 16

Doesnt have granulocytes

Question 17

Myeloblast to neut. pathway (6)

Answer 17

Myeloblast
Promyelocyte
Myelocyte
Metamyelocyte
Band cell
Segmented cell

Question 18

Name of RBC before it looses his nucleus

Answer 18

Orthochromatic normoblast

Question 19

RBC pathway (6)

Answer 19

Proerythroblast
Basophilic erythroblast
Polychromatic erythroblast
Orthochromatic erythroblast
Reticulocyte
Erythroblast

Question 20

Why male have more RBC?

Answer 20

Testosteron → EPO↑

Question 21

Medical term describing RBC with unequal size

Answer 21

Anisocytosis

Question 22

Normal % of reticulocytes in the blood

Answer 22

1-2%

Question 23

תא דם אדום בצורת קיפוד

Answer 23

Echinocyte (Burr cell)

Question 24

When will we see echinocytes?

Answer 24

Altered lipid memb
Artifact
Uremia

Question 25

RBC with nuclear remmnatn=

Answer 25

Howell Jolly body

Question 26

When will we see Spherocytes?

Answer 26

Hereditary spherocytosis | Immune Hemolytic Anemia

Question 27

B12 absorbtion

Answer 27

Parietlal cells in stomach secrete Intrinsic factors

Question 28

B12 absorbtion location

Answer 28

Terminal ileum

Question 29

Define Pernicios anemia

Answer 29

Gastritis with production of autoantibodies against Parietal cells or against Intrinsic factors

Question 30

When will Haptoglobin level decrease

Answer 30

When it will bind free Hemoglobin

Question 31

What is Hepcidin?

Answer 31

Acute phase reactant

Question 32

Hepcidin mechanism

Answer 32

Binds ferroportin | Decreases iron release from MPH

Question 33

Why PLT↑ in inflammatory process?

Answer 33

IL-6 acts on liver Release TPO Increases PLT

Question 34

Why Ferritin↑ in inflammatory process?

Answer 34

Acute phase reactant

Question 35

How does alcohol effects PLT?

Answer 35

Decrease production of TPO bcd of liver damage

Question 36

Why monocytes ↑ in alcoholic patients?

Answer 36

Common alteration

Question 37

Where is B12 stored?

Answer 37

Liver

Question 38

Why B12↑ in liver damage?

Answer 38

B12 is normally stored in liver

Question 39

Why MCV↑ in alcohol induced anemia?

Answer 39

Decreased folate levels leads to decreased DNA synthesis

Question 40

Spleen was removed. What will happen to PLT?

Answer 40

↑

Question 41

RBC in periphery with a nucleus=

Answer 41

Orthochromatic normoblasts

Question 42

What can trigger sickle cell disease?

Answer 42

Inflammatory process

Question 43

Explenation for WBC↑ in sickle cell disease?

Answer 43

Microclots causing tissue damage

Question 44

Tongue smooth shiny sensitive also called=

Answer 44

Hunter glossitis

Question 45

Hunter glossitis is seen in what disease?

Answer 45

B12/Folate deficiency

Question 46

Bone ,arrow smear of pernicious anemia patient will show us

Answer 46

Howell Jolly bosied | Megaloblasts