Pathophys II- Lymphoid disease

Question 1

Infectious mononucleosis is caused by

Answer 1

EBV

Question 2

What cells are affected by Infectious mononucleosis

Answer 2

B cells

Question 3

ALL peak at age

Answer 3

2-5 years

Question 4

Second increase incident of ALL is after age

Answer 4

50

Question 5

B-ALL markers

Answer 5

CD10
CD19
CD22
CD79a

Question 6

T-ALL markers

Answer 6

CD3

CD7

Question 7

B-ALL cytogenic subtypes

Answer 7

t(12;21)

t(9;22)

Question 8

B-ALL represent __ of ALL

Answer 8

80%

Question 9

Very poor prognosis with which abnormality?

Answer 9

t(9;22)

Question 10

Prognosis for CLL?

Answer 10

Good

Question 11

Tumor cell appear to be __ in CLL

Answer 11

Mature B cell

Question 12

What is the most common cytogenic abnormality in CLL

Answer 12

Deletion of 13q14

Question 13

Diagnosis of CLL (blood)

Answer 13

Peripheral blood lymphocyte count > 5 G/L

Question 14

Diagnosis of CLL (Bone marrow)

Answer 14

Bone marrow aspiration showing > 30% lymphocytes

Question 15

Composition of normal bone marrow

Answer 15

Granulocyte 60%
Erytrocyte 20%
Lymphocyte 10%

Question 16

CLL peripheral blood smear will show

Answer 16

Lymphocyte with thin cytoplasm

Smudge cells

Question 17

Staging system for CLL

Answer 17

Rai

Binet

Question 18

CLL treatment

Answer 18

Incurable

Question 19

OK but what can we do?

Answer 19

Anti-CD20 = RItuximab

Question 20

Rai staging

Answer 20

0-IV

Question 21

Binet staging

Answer 21

A
B
C

Question 22

EBV will show ___ on histology

Answer 22

Atypical lymphocytes

Downey types

Question 23

EBV symptoms

Answer 23

Rash
Fever
Lymphadenopathy
White coating on tonsils
Splenomegaly

Question 24

EBV causes

Answer 24

Infectious mononucleosis

Question 25

Infectious mononucleosis will present as

Answer 25

Lymphoproliferative disorder of B cells

Causes atypical B cells

Question 26

Rai staging 0 means

Answer 26

Lymphocytosis with no symptoms

Question 27

How can we exclude ALL?

Answer 27

No splenomegaly

Question 28

Where can we find Smudge cells?

Answer 28

CLL

Question 29

BUN means

Answer 29

Blood Urea Nitrogen

Question 30

Common finding in MONO (Blood smear)

Answer 30

Atypical lymphocytes

Question 31

Atypical lymphocytes are also called

Answer 31

Downey cells

Question 32

More exams performed on a patient with EBV

Answer 32

Heterophile Ab test

Question 33

What is Heterophile Ab test

Answer 33

We test for the Ab produced against EBV Ag

Question 34

Rai systemstage 0=

Answer 34

Lymphocytosis without symptoms

Question 35

What is the most common type of leukemia?

Answer 35

CLL