Pathoma Breast Disease Flashcards
Fibroadenoma
In premenopausal women, well defined mobile mass that increases with estrogen. No risk of cancer (unless biopsy shows risky cells – sclerosing adenitis, epithelial hyperplasia, intraductal papilloma.
Fibrocystic changes
Blue dome, papillary apocrine change /metaplasia, stroma fibrosis. No increased risk of cancer.
Sclerosing adenosis
Calcifications, Slight increased risk of cancer
Intraductal papilloma
Most common cause of nipple discharge (serous or bloody). Slight increased risk for cancer, but biopsy will show both epithelial layers
Epithelial hyperplasia
Increased cells in terminal ductal or lobular epithelium. Increased risk of carcinoma with atypical cells.
Phyllodes tumor
leaf like lobuations. Like fibroadenoma but in older women. May become malignant.
Fat necrosis
Calcified oil cyst, necrotic fat and giant cells on biopsy
Subareolar mass with nipple retraction
Can be periductal mastitis, seen in smokers.
Post menopausal woman with mass and green brown nipple discharge
Mammary duct ectasia.
Biopsy shows chronic inflammation with plasma cells.
Comedocarcinoma
ductal carcinoma with central necrosis and dystrophic calcifications
Paget disease of nipple
Results from underlying DCIS or invasive breast cancer. Paget cells are intraepithelial adenocarcinoma cells.
Indian file
Invasive lobular carcinoma of breast. Due to decreased E cadherin expression.
BRCA1 associated with:
breast (medullary has high association) and ovarian (and fallopian)
Inflammatory breast cancer
Dermal lymphatic invasian by breast carcinoma. Peau dorange
BRCA2 assocation
Breast carcinoma in males
