Oncogenes Flashcards
1
Q
ALK
A
Receptor tyrosine kinase
Lung adenocarcinoma
2
Q
BCR-ABL
A
Tyrosine kinase
CML, ALL
3
Q
BCL-2
A
Antiapoptotic molecule (inhibits apoptosis) Follicular and diffuse large B cell lymphoma
4
Q
BRAF
A
Serine/threonine kinase
Melanoma, non-Hodgkin Lymphoma
5
Q
c-KIT
A
Cytokine receptor
Gastrointestinal stromal tumor (GIST)
6
Q
c-MYC
A
Transcription factor
Burkitt lyphoma
7
Q
HER2/neu (c-erbB2)
A
Tyrosine kinase/growth factor receptor
Breast and Gastric carcinoma
8
Q
JAK2
A
Tyrosine kinase
Chronic myeloproliferative disorders
9
Q
KRAS
A
GTPase
Colon cancer, lung cancer, pancreatic caner
10
Q
MYCL1
A
Transcription factor
Lung tumor
11
Q
MYCN
A
Transcription factor
Neuroblastoma
12
Q
RET
A
Tyrosine kinase
MEN 2A and 2B, medullary thyroid cancer