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MD2 Ambulatory Care and Emergency Medicine > Pathology of Inflammatory Skin Disease > Flashcards

Pathology of Inflammatory Skin Disease Flashcards

You may prefer our related Brainscape-certified flashcards:
Royal College: Emergency Medicine flashcards
1
Q

What are different epidermal reaction patterns?

A 
Spongiotic
Psoriasiform
Bullous and pustular
Interface reactions
- Lichenoid
- Vacuolar
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2
Q

What are different dermal reaction patterns?

A 
Oedematous
Vasculopathic
Inflammatory, including granulomatous
Fibrosing
Infiltrative
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3
Q

What does curettage yield?

A

Fragmented tissue

  • Keratotic material/crust
  • Epidermis
  • Minimal dermis
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4
Q

For what may curettage be suitable?

A

Seborrhoeic keratoses

Superficial basal cell carcinomas

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5
Q

What does a shave biopsy yield?

A

Single piece of unfragmented epidermis +/- superficial dermis

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6
Q

For what may a shave biopsy be suitable?

A

Some keratoses

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7
Q

What is obtained from a punch biopsy?

A

Epidermis
Dermis
Sometimes subcutaneous fat

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8
Q

For what may a punch biopsy be suitable?

A 
Inflammatory dermatoses
Confirmation of suspected tumour, usually
- Basal cell carcinoma
- Squamous cell carcinoma
Discrete small lesions
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9
Q

What is obtained from an incisional biopsy?

A

Epidermis
Dermis
+/- subcutaneous fat
May include fascia

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10
Q

For what may an incisional biopsy be suitable?

A

Blistering lesions, especially if roof delicate
Ulcerated lesions - some normal skin assists assessment
Inflammatory process extending into fat

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11
Q

What does an excisional biopsy allow?

A

Histological examination of entire lesion

Accurate assessment of depth and margins

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12
Q

For what may an excisional biopsy be suitable?

A

Intent to cure
Non-uniform lesions, especially pigmented
Suspected melanoma

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13
Q

When is a wide local excision done?

A

Usually after biopsy diagnosis of melanoma/other locally aggressive malignancy

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14
Q

What does a wide local excision remove?

A

Any residual lesion to level of subcutaneous fat

- May include fascia

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15
Q

What are the differential diagnoses of spongiotic reactions?

A

Eczema
Seborrhoeic dermatitis
Fungal infection
Early immuno-bullous disorder

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16
Q

What are the differential diagnoses of psoriasiform reactions?

A 
Psoriasis
Chronic spongiotic reactions
Lichen simplex chronicus
Psoriasiform keratosis
AIDS associated dermatitis
Reiter's syndrome
17
Q

What are the differential diagnoses of blistering reactions?

A

Depends on

  • Location of blister
  • Process causing blister
  • Contents of blister
  • Presence and type of inflammatory reaction
  • Presence of autoAbs
18
Q

What are some important blistering reactions?

A 
Genetic
- Darier
- Hailey-Hailey
Impetigo
Viral infections
Immuno-bullous disorders
- Pemphigus
- Pemphigoid
- Dermatitis herpetiformis
Burns
Erythema multiforme
Drug reactions
Arthropod bite reactions
19
Q

What are the differential diagnoses of interface/lichenoid reactions?

A 
Lichen planus
Lichenoid drug eruption
Fixed drug eruption
Erythema multiforme
Cutaneous lupus
Dermatomyositis
Graft vs host disease
20
Q

What are the differential diagnoses of cutaneous small vessel vasculitis?

A

Infective
Immunological
- Immune complex
- Direct Ab associated

21
Q

Define acantholysis

A

Loss of cohesion between keratinocytes

22
Q

Define acanthosis

A

Epidermal hyperplasia

23
Q

Define dyskeratosis

A

Permature keratinisation below granular layer

24
Q

Define erosion

A

Incomplete loss of epidermis

25
Q

Define exocytosis

A

Epidermal infiltration by inflammatory cells

26
Q

Define hypergranulosis

A

Hyperplasia of stratum granulosum

27
Q

Define hyperkeratosis

A

Thickening of stratum corneum

28
Q

Define papillomatosis

A

Expansion of dermal papillae > surface undulation

29
Q

Define parakeratosis

A

Keratinisation with retained nuclei in stratum corneum

30
Q

Define spongiosis

A

Intercellular oedema in epidermis

31
Q

Define ulceration

A

Complete loss of epidermis to dermis/subcutis

MD2 Ambulatory Care and Emergency Medicine (29 decks)

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