Approach to Red Eye Flashcards

1
Q

What does initial stabilisation involve?

A

Is there a life-threatening problem concurrent to red eye?

Does the red eye suggest a broader life/function threatening problem?

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2
Q

What does a red eye history involve?

A
HOPC
Important distinction
- Unilateral
- Bilateral
PHx
Past ocular Hx
SHx
Rx
Allergies
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3
Q

What does a red eye clinical examination involve?

A
General inspection
Visual acuity
- +/- further visual exams if vision problem suspected
Pupil reactions
Intra-ocular pressure
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4
Q

From superficial to deep structures, what is observed in a slit lamp examination?

A
Lids
Tear film
Conjunctiva
Episclera and sclera
Cornea
Anterior chamber
Iris
Pupil
Lens
Fundus
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5
Q

What is the clinical presentation of ectropion?

A

“My eye is red and waters a lot”

Eversion of eyelid

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6
Q

What can cause ectropion?

A

Facial nerve palsy

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7
Q

What is the management of ectropion?

A

Ocular lubricants

Consider surgical repair if lid position doesn’t improve over next 3 months

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8
Q

What is the clinical presentation of entropion?

A

“My eye is red and feels very irritated”

Inversion of lower eyelid

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9
Q

What is the management of entropion?

A

Surgical repair to prevent lashes rubbing on ocular surface

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10
Q

What is the clinical presentation of blepharitis?

A

“My eye has been red and itchy for a few weeks”
Crust formation around lashes
Associated inflammation

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11
Q

What is the management of blepharitis?

A
Daily routine of lid margin hygiene
- Warm face washer applied over eyelids > opens clogged meibomian glands
- Mechanical removal of lid debris
- Avoid makeup
Topic antibiotics in refractory cases
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12
Q

What is the clinical presentation of chalazion?

A

“Is it a stye?”

Swelling above eyelash margin

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13
Q

What is the management of chalazion?

A

Often self-resolving

If refractory > incision and curette

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14
Q

What is the clinical presentation of periorbital cellulitis?

A

“My eye has been painful, red, and swollen over the past 2-3 days”
Visual acuity intact
PEARL
Normal intraocular pressure
Red, hot oedematous, tender skin over eyelid
Clear conjunctiva

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15
Q

What are the common infectious agents causing periorbital cellulitis?

A
Staph aureus
Strep pyogenes
Come from
- Skin
- Sinuses
- Meibomian glands
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16
Q

What is the treatment for periorbital cellulitis?

A

Oral antibiotics

Greater risk of progression to orbital cellulitis in children > more aggressive treatment

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17
Q

What is the clinical presentation of orbital cellulitis?

A
Onset over few days
Painful red eye +/- diplopia and visual impairment
Fever
Nausea
Malaise
Tachycardia
Sluggish pupil of affected eye
Raised intraocular pressure
Red, hot, oedematous, tender skin over eyelids
Conjunctival chemosis
Proptosis possible - difficult to assess due to lid swelling
Potentially life and site threatening
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18
Q

What are the common infectious agents causing orbital cellulitis?

A
S aureus
S pyogenes
Haemophilus influenzae
Most often spread from sinuses
Can arise from
- Tear ducts
- Trauma to orbit
- Periorbital cellulitis
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19
Q

What is the treatment for orbital cellulitis?

A
CT orbits/brain > confirm diagnosis
Swab purulent discharge
IV antibiotics
ENT review
May need surgical drainage if abscess formed
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20
Q

What is the clinical presentation of dry eyes?

A

“My eyes are often red and sore”
“Sometimes they become very watery”
Fluorescent staining viewed under Cobalt-blue light filter
- Punctuate epithelial erosions in lower third of cornea

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21
Q

Why do the eyes water in dry eyes?

A

Reflex tears produced in response to ocular surface irritation

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22
Q

What is Sjogren’s syndrome?

A

Reduced aqueous tear production
Systemic autoAbs present
- Rheumatoid factor
- Anti-nuclear Abs

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23
Q

What tests are ordered from a conjunctival swab for conjunctivitis?

A
MCS = microscopy, culture, and sensitivities
Adenovirus PCR
HSV PCR
VZV PCR
RSV PCR
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24
Q

What is the incidence of bilateral conjunctivitis in bacterial, viral, and allergic conjunctivitis?

A
Bacterial = 1/2-3/4
Viral = 1/3
Allergic = most
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25
What is the discharge in bacterial, viral, and allergic conjunctivitis?
``` Bacterial = mucopurulent in younger children Viral = mild/watery/"sleepers" Allergic = rare ```
26
What is the incidence of redness in bacterial, viral, and allergic conjunctivitis?
``` Bacterial = common in older children, uncommon in infants and toddlers Viral = usually Allergic = usually ```
27
What is the incidence of acute otitis media in bacterial, viral, and allergic conjunctivitis?
``` Bacterial = 1/3 Viral = 10% Allergic = no ```
28
Are eyes itchy in bacterial, viral, and allergic conjunctivitis?
``` Bacterial = no Viral = no Allergic = yes ```
29
What is the clinical presentation pterygium?
"My eye has been red for years, especially after I have been out in the sun. I think it's getting worse" Triangular membrane on ocular surface from medial canthal region
30
What are the reasons for the surgical removal of a pterygium?
``` Threat to vision by - Growth over visual axis - Distorting cornea > astigmatism Symptom relief Cosmetic reasons ```
31
What is the clinical presentation of sub-conjunctival haemorrhage?
"I was injured in an accident" "I've had a cough recently, and been on antibiotics. I also take warfarin" Common
32
What is the treatment of sub-conjunctival haemorrhage?
Self-resolving
33
Is sub-conjunctival haemorrhage serious?
Usually, no May suggest serious pathology in some cases - Base of skull fracture - Supra-therapeutic warfarin dosage
34
What is the general clinical presentation of carotid-cavernous fistula, and what are the types?
Unilateral red eye with chemosis Types - Low flow - High flow
35
Where is the fistula in low flow carotid-cavernous fistula?
Meningeal branches of carotid arteries > canvernous sinus
36
What are the features of low flow carotid-cavernous fistula?
``` Chronic red eye Unilateral intraocular pressure rise Orbital venous congestion Can be pulsatile Risk factors - HTN - Arteriosclerosis ```
37
What is the prognosis for low flow carotid-cavernous fistula?
Often resolves spontaneously
38
Where is the fistula in high flow carotid-cavernous fistula?
Internal carotid artery > cavernous sinus
39
What are the features of high flow carotid-cavernous fistula?
``` Secondary to trauma Decreased visual acuity Pulsatile proptosis Bruit Raised intraocular pressure Can have ocular ischaemia Can have associated cranial nerve palsies ```
40
What is the treatment for high flow carotid-cavernous fistula?
Radiological coiling/embolisation to close defect
41
What is the initial investigation for carotid-cavernous fistula?
CT
42
What is the clinical presentation of episcleritis?
``` Mild eye discomfort Itching Watering No visual disturbance Can be diffuse/sectoral ```
43
What are the causes of episcleritis?
Idiopathic May be associated with - Vasculitis - Connective tissue disorders
44
What is the treatment for episcleritis?
Usually self-limiting Sometimes needs - Ocular lubricants - Topical NSAIDs
45
What is the clinical presentation of scleritis?
Severe aching pain > disturbs sleep Tender globe Vision may be affected Violaceous hue and injection of scleral vessels
46
What are some conditions associated with scleritis?
``` Rheumatoid arthritis Granulomatosis with polyangiitis Relapsing polychondritis Polyarteritis nodosa Lupus - rare ```
47
What is the management for scleritis?
Urgent referral to ophthalmologists
48
How can a metallic foreign body be removed from the cornea?
Copious topical anaesthesia Removal with bevel of needle Rust ring removed with dental burr Removal over axis of vision should be attempted by an ophthalmologist
49
Why is it important to evert the eyelid in the case of a foreign body in the eye?
Foreign body can be sub-tarsal | Scratches over cornea
50
What is the clinical presentation of a penetrating eye injury?
"Welding flash" > painful red eye Fluorescein dye administered > switch off lights > cornea viewed under blue light Positive Seidel's sign
51
What is a positive Seidel's sign?
Aqueous humour displacing fluorescein dye on corneal surface
52
What is the management of a penetrating eye injury?
Urgent ophthalmological referral for - Dilated fundus exam - Surgical opinion
53
What are the differences between acidic and alkaline eye injuries?
Acid tends to denature protein > barrier created > prevents further spread Alkali penetrates more deeply
54
What is the acute management of a chemical eye injury?
Immediate copious irrigation for at least 30 min Determine pH on arrival to hospital Continue irrigation until pH normal Topical anaesthesia to cornea > lid eversion > removal of particulate matter with swab Topical antibiotic cover Topical steroids Intraocular pressure control
55
What is the clinical presentation of bacterial keratitis?
"My eye is sore, and it feels like there's something in it" "My vision is also blurred" "I can't wear my contact lenses today" Focal dense stromal infiltrate of neutrophils and bacteria Sharply demarcated epithelial defect Corneal oedema
56
What are the most common causative organisms of bacterial keratitis?
S aureus S pneumoniae Pseudomonas aeruginosa
57
What is the management of bacterial keratitis?
Corneal swab > MSC Intensive broad spectrum topical antimicrobial therapy Consider systemic antimicrobial therapy if threatened perforation exists
58
What is the complication of bacterial keratitis?
Endophthalmatitis
59
What are the differential diagnoses for contact-related microbial keratitis?
Bacterial keratitis | Acanthamoeba keratitis
60
What is the clinical presentation of acanthamoeba keratitis?
``` Swimming whilst wearing contact lenses Gradual increase in discomfort over weeks Early exam - Epithelial irregularity/erosions - Infiltrates around corneal nerves = radial keratoneuritis Late exam - Corneal stromal infection - Dense ring infiltrate ```
61
What is the treatment for acanthamoeba keratitis?
Topical antiseptics = chlorhexidine Propamidine isethionate Can need corneal transplant once infection cleared
62
What is seen on fluorescein staining in herpes simplex keratitis?
Dendritic ulcer
63
What can repeated reactivations of herpes simplex in the cornea lead to?
Corneal scarring | Blindness
64
What is the treatment for herpes simplex keratitis?
Topical acyclovir for 2 weeks | +/- oral antivirals
65
What is the clinical presentation of corneal melt?
``` Gradual onset of - Foreign body sensation - Watering - Reduced vision Red eye Peripheral corneal stromal thinning and ulceration ```
66
What is the management of corneal melt?
Urgent referral to ophthalmologist
67
What is the clinical presentation of iritis/anterior uveitis?
Painful red eye Blurred vision Photophobia Flare and cells in anterior chamber
68
What is iritis?
Inflammation of iris and anterior chamber
69
What is the treatment for iritis?
Topical glucocorticoids | Cycloplegics
70
What are the complications of iritis?
Cataract Glaucoma Macular oedema
71
What are the infectious causes of iritis?
HSV/HZV TB Syphilis Lyme disease
72
What is hyphaema?
Blood in anterior chamber
73
What is hyphaema due to?
Usually trauma | Can occur spontaneously; eg: secondary to neovascularisation
74
What are the complications of hyphaemia?
Glaucoma Corneal staining Re-bleed
75
What is the treatment for hyphaema?
Topical steroids and cycloplegics | Sleep at 45 degrees/sitting up > reduce risk of corneal staining until hyphaema resolved
76
What is the clinical presentation of endophthalmitis?
Severe pain Vision loss Recent intraocular surgery/penetrating eye injury Inflammation of multiple ocular structures
77
What is the investigation for endophthalmitis?
Find source of inflammation > tissue diagnosis imperative
78
What is the treatment for endophthalmitis?
Targeted antimicrobial therapy Intravitreal (+ systemic if infection systemic) Pars plana vitrectomy may be needed Enucleation for blind and painful eye
79
What causes exogenous endophthalmitis?
Secondary to - Surgery - Penetrating eye injury - Intraocular foreign body
80
What causes endogenous endophthalmitis?
``` Systemic infection Most common pathogens - Candida albicans - S aureus - E coli ```
81
What is the clinical presentation of acute angle closure glaucoma?
``` Few hours of painful unilateral red eye Worsening vision If to touch eye, would be hard Cloudy oedematous cornea Mid-dilated pupil Raised intraocular pressure ```
82
What is the emergency management of acute angle closure glaucoma?
Intraocular pressure reduction Acetazolamide IV and oral STAT Topical beta-blocker Topical steroids
83
Cases of red eye involving the fundus require what during examination?
Dilated fundal examination
84
What are the causes of red eye involving the fundus?
``` Trauma Penetrating eye injury Inflammatory disorders - Uveitis - Scleritis Infection ```
85
What are the common causes of unilateral red eye?
``` Sub-conjunctival haemorrhage Pterygium Ectropion Corneal foreign body Herpes simplex keratitis Iritis ```
86
What are the common causes of bilateral red eyes?
Viral conjunctivitis Dry eye Blepharitis
87
What are the causes of red eye that need immediate emergency management?
Chemical eye injury Penetrating eye injury Acute angle closure glaucoma
88
What causes of red eye need referral to an ophthalmologist?
Unexplained decreased function - Visual acuity - Visual field - Colour vision - Abnormal pupil reactions - Increased intraocular pressure - An potential intra-ocular/-orbital pathology