Approach to Visual Loss Flashcards

1
Q

What does initial stabilisation involve?

A

Is there a life-threatening problem concurrent to visual loss?
Does the visual loss suggest a broader life/function threatening problem?

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the important points in a visual loss history?

A
HOPC
Unilateral/bilateral
PHx
Past ocular Hx
FHx
SHx
Rx
Allergies
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the important points in a visual loss examination?

A

Visual acuity
Pupil reactions
Intraocular pressure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which structures are most likely to be involved in visual loss?

A

Structures within visual axis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the most common cause of poor vision?

A

Refractive error

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are some neurological causes of ptsosis?

A

CN III palsy

Horner’s syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are some myogenic causes of ptosis?

A

Myaesthenia gravis

Myotonic dystrophy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are some aponeurotic causes of ptosis?

A

Involutional

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are some mechanical causes of ptosis?

A

Orbital tumours
Oedema
Scarring

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is a cause of pseudoptosis?

A

Contralateral lid retraction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What mitochondrial disease can cause ptosis?

A

Chronic progressive external ophthalmoplegia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What should you think of when there’s transient blurring of vision, with or without epiphoria?

A

Tear film disruption

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

How can entropion blur vision?

A

Tear film disruption

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Over time, what can entropion cause?

A

Corneal scarring

Pannus trichiasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is pannus trichiasis?

A

Misdirected growth of eyelashes towards cornea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What causes trachoma?

A

Chlamydia trachomatis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What are the complications of chronic trachoma?

A

Scarring of conjunctiva
Entropion
Blindness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What is the clinical presentation of Fuch’s endothelial dystrophy?

A

“My vision has been gradually getting blurry over months”
Corneal oedema
Descemet’s membrane folds
Same findings in contralateral eye

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What is Fuch’s endothelial dystrophy?

A

Decompensation of corneal endothelial pump > corneal oedema

Usually bilateral

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What is the treatment for Fuch’s endothelial dystrophy?

A

Topical 5% NaCl > dehydrates cornea
Corneal graft surgery
- Graft of endothelium only usually sufficient

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What is the clinical presentation of keratoconus?

A
"My vision has been getting  blurry again. I've had several new pairs of glasses this year, but it keeps getting worse"
FHx
Young age
Visual acuity corrected with pin hole > not always, though
PEARL
Normal intraocular pressure
Irregular curvature of cornea
Munson's sign
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What is Munson’s sign?

A

V shape in lower lid when looking down due to irregular shape of cornea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What is keratoconus?

A

Progressive thinning, weakness, and protrusion of cornea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Which layer of the cornea is primarily affected in keratoconus?

A

Stroma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
What is the management of keratoconus?
Hard contact lenses Cross-linking Corneal transplant
26
What is the clinical presentation of acute angle closure glaucoma?
Few hours of painful unilateral red eye and worsening vision Cloudy oedematous cornea Mid-dilated pupil Raised intraocular pressure
27
What is the emergency management for acute angle closure glaucoma?
Reduce intraocular pressure Acetazolamide oral and IV STAT Topical beta-blocker Topical steroids
28
What is the clinical presentation of a cataract?
``` Gradual worsening of vision Glare Colours not as bright anymore Usually in older people Visual acuity not improved with pin hole PEARL Normal intraocular pressure Sclerosis of lens ```
29
What are the different types of cataract?
Cortical Nuclear Subcapsular
30
What are causes of cataracts?
``` Age-related Drugs - Steroids - Amiodarone Trauma, including intraocular surgery Systemic diseases - Diabetes - Myotonic dystrophy - Wilson's disease - Atopic dermatitis Ocular diseases - Uveitis - Myopia ```
31
What is the treatment for cataracts?
Lens removal and introcular lens insertion
32
What is the pathophysiology of a dislocation of the lens?
Zonular pathology
33
What is lens dislocation associated with?
Connective tissue disorders, including Marfan syndrome
34
What is the clinical presentation of vitreous haemorrhage?
"I lost vision in one eye today. It was like a curtain came down over my vision" Affected eye VA: 6/60 PEARL Nil RAPD
35
What are some important causes of vitreous haemorrhage?
Retinal detachment Proliferative diabetic retinopathy Trauma
36
What is the management for vitreous haemorrhage?
Often resolves slowly over weeks/months Can need vitrectomy to clear blood Risk of re-bleed
37
What is the clinical presentation of retinal detachment?
``` Flashes of light in one eye = traction of retina Floaters in one eye RAPD with extensive retinal detachment Retinal detachment with fundoscopy - Difficult to see in peripheries - Need to dilate pupil ```
38
What is the management for retinal detachment?
Urgent ophthalmological review | Surgical repair
39
What is a Weiss ring a sign of?
Posterior vitreous detachment
40
What is the clinical presentation of a central retinal artery occlusion?
``` Sudden, painless, unilateral loss of vision RAPD Pale retina Arteriolar attenuation Cerry red spot ```
41
How quickly does irreversible ischaemic damage to the retina occur?
After 90 min
42
What are the common causes of central retinal artery occlusion?
Atherosclerosis Emboli Haematological disorders Inflammatory; eg: giant cell arteritis
43
What is the emergency management of central retinal artery occlusion?
``` Urgent priority to rule out GCA - ESR - CRP Lie patient flat Ocular massage Decrease introcular pressure > acetazolamide 500 mg IV STAT ```
44
What is the clinical presentation of central retinal vein occlusion?
``` Sudden, painless, unilateral loss of vision RAPD Retinal haemorrhages Macular oedema Cotton wool spots ```
45
What atherosclerotic associations are there with central retinal vein occlusion?
HTN Diabtes Hyperlipidaemia Smoking
46
What inflammatory diseases are associated with central retinal vein occlusion?
Sarcoidosis Behcet's disease SLE Polyarteritis nodosa
47
What blood dyscrasias are associated with central retinal vein occlusion?
Protein C and S deficiency Antithrombin deficiency Antiphospholipid syndrome Multiple myeloma
48
What ophthalmic conditions are associated with central retinal vein occlusion?
Glaucoma | Orbital mass
49
How does central retinal vein occlusion cause rubeosis iridis?
Blood vessels grow into iris
50
What is the treatment for central retinal vein occlusion?
Lifestyle changes Intraocular pressure control Intravitreal steroids Anti-VEGF agents
51
What is the clinical presentation of a macular hole?
"I can't focus on anything with one eye. When I try and look at something, it disappears" Visual fields by confontration normal
52
What is the management for a macular hole?
Vitrectomy Removal of macular traction Insertion of gas
53
What is the clinical presentation of dry age-related macular degeneration?
``` Gradual decrease in central vision Central scotoma FHx of macular degeneration Drusen Geographic atrophy = coalesced drusen ```
54
What is the pathophysiology of dry age-related macular degeneration?
Loss of retinal pigment epithelium/photoreceptors Associated with - Increasing age - Smoking
55
What is the management for dry age-related macular degeneration?
``` Predominantly supportive care Smoking cessation Vitamin supplementation > thought to reduce oxidative stress in retina - Vitamin C and E - Zinc - Copper ```
56
What is the clinical presentation of wet age-related macular degeneration?
``` Rapid decrease in central vision - weeks-months Metamorphopsia Central scotoma Drusen Geographic atrophy Lipid exudate Intra-retinal haemorrhage ```
57
What is the pathophysiology of wet age-related macular degeneration?
Choroidal neovascularisation = growth of abnormal leaky vessels in RPE
58
What is the management of wet age-related macular degeneration?
Investigate with fluorescein angiography and optical coherence tomography Anti-VEGF intra-vitreal injections
59
What is the biggest risk factor for diabetic retinopathy?
Duration of diabetes
60
What are other risk factors for diabetic retinopathy?
``` Poor glycaemic control Poorly controlled HTN Hypercholesterolaemia Nephropathy Pregnancy Obesity ```
61
What is the most common cause of visual impairment in diabetic retinopathy?
Diabetic macular oedema
62
What are some features of diabetic retinopathy on fundoscopy?
``` Circinate ring Lipid (hard) exudates Intra-retinal haemorrhage Micro-aneurysms Venous beading Intra-retinal vascular abnormalities Neovascularisation of disc Neovascularisation everywhere Vitreous haemorrhage ```
63
What is the epidemiology of retinitis pigmentosa?
Most common retinal dystrophy Sporadic/inherited Affects rods first Usually in young adults
64
What is the clinical presentation of retinitis pigmentosa?
``` "I'm concerned about my vision. I've nearly been in a few car accident. My night vision is so bad, that I've stopped driving in the dark altogether. Blindness tends to run in my family" Normal visual acuity PEARL Nil RAPD Intraocular pressure normal Annular scotoma Waxy pallor of disc Bone-spiculae retinal pigmentation Retinal arteriolar attenuation ```
65
What does posterior uveitis include?
Retinal vasculitis Retinitis Choroiditis
66
What are some causes of posterior uveitis?
``` Systemic inflammatory disorders - Behcet's disease - Sarcoidosis Viruses Fungal Protozoa Bacterial Lymphoma ```
67
What is the management of posterior uveitis?
``` Investigate cause Assess risk of bilateral vision loss Antimicrobials if infective cause Topical steroids Intraocular antimicrobials and steroids Systemic therapies ```
68
What is the clinical presentation of idiopathic (benign) intracranial hypertension?
Overweight, female, 20s Headaches Blurry vision Bilateral swollen optic discs = papilloedema
69
What are the investigations for idiopathic intracranial hypertension?
Urgent neuroimaging | Lumbar puncture if cause not clear
70
What is the treatment for idiopathic intracranial hypertension?
``` Weight loss Medical Rx - Acetazolamide - Other diuretics - Corticostreoids Surgical Rx - Optic nerve sheath fenestration - Lumbar-peritoneal shut ```
71
What is the clinical presentation of optic neuritis?
"I woke up this morning and have very poor vision in one eye" RAPD in affected eye Normal intraocular pressure Reduced colour saturation in affected eye Blurred optic disc margin Swollen, inflamed, disc = papillitis
72
What is the management for optic neuritis?
MRI brain and referral to neurologist to investigate for multiple sclerosis High dose prednisolone
73
What are the causes of bilateral disc swelling?
Generally papilloedema Malignant HTN Pseudopapilloedema
74
What are causes of raised intracranial pressure due to mass effect?
Haemorrhage Haematoma Tumours
75
What are the causes of raised intracranial pressure due to increased CSF production?
Choroid plexus tumour
76
What are the causes of raised intracranial pressure due to reduced CSF absorption?
Venous sinus thrombosis Aqueduct/foramen stenosis Idiopathic intracranial hypertension
77
What are the causes of unilateral disc swelling?
Arteritic anterior ischaemic optic neuropathy Non-arteritic anterior ischaemic optic neuropathy Optic neuritis Tumours Infections
78
What are the causes of unilateral disc swelling reated to raised intracranial pressure?
Foster-Kennedy syndrome | Raised ICP where 1 optic disc already atrophic
79
What are the causes of pseudopapilloedema?
Optic disc drusen Hypermetropia = shorter eye axial length > gives disc swollen appearaance Tilted discs
80
What are the clinical features of giant cell arteritis?
Headache Scalp tenderness Jaw claudication Associated polymyalgia rheumatica Acute unilateral loss of vision - Usually due to ischaemic optic neuropathy - Can be due to central retinal artery occlusion
81
What are the investigations for giant cell arteritis?
ESR - classically >100 CRP Temporal artery biopsy
82
What is the treatment for giant cell arteritis?
40-60 mg prednisolone (high dose)
83
What is primary open angle glaucoma?
Chronic degenerative condition affecting optic nerve
84
What is the progression of visual field loss in glaucoma?
Normal fields with blind spot > Arcuate scotoma - usually not noticed by patient > Progression of centrally sparing field loss - patient can still be unaware > Snuff out - can present as acute vision loss
85
What are the signs of primary open angle glaucoma?
Increased optic cup-to-disc ratio | Progressive visual field loss
86
What are the risk factors for primary open angle glaucoma?
Positive FHx High myopia Diabetes Elevated intraocular pressure
87
What are the most common causes of vision loss?
``` Refractive error Cataracct Diabetic retinopathy Macular degeneration Ocular surface disease ```