Pathology Flashcards
3 components of acute inflammation
vascular changes
structural changes
immigration of neutrophils (PMNs)
chronic inflammation involves infiltration of what cells?
mononuclear (macrophages, lymphocytes and plasma cels)
3 components of chronic inflammation
infiltration of mononuclear cells
tissue destruction
repair involving new vessel prolif.
coagulative necrosis happens after a…
myocardial infarction
liquefactive necrosis is seen in … infections in the….
fungal
lung
caseous necrosis is most often seen in … and the central necrotic tissue in this appears…
TB
white and cheesy
what are the 4 hypersensitivity reactions?
Anaphylactic type 1
Cytotoxic type 2
Immune complex mediated type 3
Delayed response type 4
in a type 1 hypersensitivity reaction, an allergen activates a …. and …. antibodies are produced and bind to the surface of mast cells and basophils.
A second exposure to the allergen causes cross-linking of …. which allows calcium to enter the cell and cause degranulation
B lymphocyte
IgE
IgE
causes of type 1 hypersensitivity?
response time?
peanuts, shellfish, penicillin, snake venom, bee stings
5-30 min
… is the primary mediator released from mast cells and basophils during a type 1 hypersensitivity rxn
histamine
erythroblastosis fetalis and rheumatic fever are both examples of what type of hypersensitivity rxn?
type 2 cytotoxic
which antibodies are involved in a type 2 cytotoxic hypersensitivity rxn?
IgG and IgM
which hypersensitivity reaction is mediated by Ag/Ab complexes?
type 3
Lupus is an example of which type of hypersensitivity rxn?
type 3
Serum sickness is an example of which type of hypersensitivity rxn?
type 3
hypersensitivity rxn type 4 is mediated by what type of cells?
T lymphocytes (memory) takes several days to develop
In hypersensitvity type 4 rxns, T lymphocytes encounter an antigen and release …. leading to ….
leukokinin
macrophage activation
TB skin test, contact dermatitis and corneal transplant rejection are all examples of which hypersensitivity rxn?
type 4 (delayed)
in gingivitis, bacteria supragingivally tend to be …. and as you go further into the tissue are more…
gram positive
gram negative
LAP usually has a … onset and periodontal damage involves no more than 2 teeth other than….
1st molars and incisors
GAP usually affects people …., attachment loss affects at least …. other than …
under 30 but can be older too
3 teeth
1st molars and incisors
NPDs are commonly seen in patients with … , … and …
HIV
malnutrition
immunosuppression
NUG and NUP have the same etiology and clinical signs except NUP involves
clinical attachment loss and alveolar bone loss
Lupus happens more often in …. and a distinctive feature is …. and the patients will produce …
women
malar butterfly rash
ANA antibodies
symptoms of lupus
joint pain
renal disorders
photosensitivity
arthritis
rheumatoid arthritis is more common in …. and happens in the … decade of life causes pain in …. joints and the pain is worse in the … and they will test positive for …
women
5th
small
morning
RF
…. syndrome is a slowly progressive inflammatory autoimmune disease affecting primarily exocrine glands, it is marked by the triad of dry mouth, dry eyes, and arthritis
sjogrens
what causes dry mouth in sjogrens syndrome
lymphocytic infiltrates replacing functional epithelium
disease that affects medium and large arteries. patient presents with scalp tenderness, jabbing neck pain, jaw caudication and fever
temporal arteritis (giant cell arteritis)
50% of patients with temporal arteritis may also develop …. which is characterizied by fatigue and morning stiffness in the hips and shoulders
polymyalgia rheumatica
what are two tests that should be run with temporal arteritis and what is the gold standard for dx?
ESR CRP
biopsy
tx for temporal arteritis
steroids
erythema multiforme can be caused by …. or …
herpes simplex virus (HSV)
drugs
erythema multiforme has distinct … lesions
targetoid (bullseye)
… is an autoimmune disease that causes severe blistering of the skin and mucous membranes lining the mouth, nose, throat and genitals
pemphigus vulgaris
pemhigus vulgaris results from circulating … antibodies directed against…
IgG
desmosomes
pemphigus vulgaris is associated with the …. sign
nikolsky’s
…. is an autoimmune disease that causes blistering skin due to a response to 2 hemidesmosomal proteins within the dermal epidermal jxn that separate
bullous pemphigus
… is an autoimmune disorder that is chronic, inflammatory and of unknown etiology. it appears to be T cell mediated. It presents with a white reticular pattern with multiple lesions in a bilateral and symmetric distribution
oral lichen planus
what disease presents with reticular lesions that consist of white papules and striations that form a lacy network called wickhams striae on the buccal mucosa, gingiva, alveolar sulcus and lower vermillion lip
oral lichen planus
can you get AIDS through saliva?
no
AIDS is cause by a …. virus that uses …. to make viral DNA within infected cells
RNA
reverse transcriptase
in AIDS, there is a severe loss of
CD4+ T cells
CD4 count of less than 500 means
CD4 count of less than 200 means
should start medication
HIV has progressed to AIDS
how is a patient tested for HIV/AIDS
ELISA test is a screening test for HIV
Western blot is used to confrim the ELISA test
what is the specificity of the ELISA and western blot for AIDS?
99.9%
what are the common opportunistic infections that usually cause death in AIDS patients?
pneumocystic pneumonia
mycobacterium tuberculosis
toxoplasmosis
CMV and HSV (kaposi’s sarcoma)
…. is a malignancy caused by the herpes virus HHV-8
kaposi’s sarcoma
…. involves the lateral borders of the tongue, it is almost exclusively in HIV patients
hairy leukoplakia
… is a gram positive infection with classic honey colored crusted lesions. very common in children
impetigo
Herpes type 1 and type 2, which one is above the belt and which one below?
1- above
2- below
90% of adults with HSV 1 obtain it from
a primary infection as a child
manifestation of primary infections of HSV type 1 is rare but it is termed…. It is extremely painful and patient will have rew swollen oral mucosa with herpetic lesions present covering mucosa
primary herpetic gingivostomatitis
after initial infection of herpes, it hides in … and can reoccur at any time
trigeminal gasserian ganglion
Varicella-zoster virus presents as
chicken pox
…. is the reactivation of VZV in the dermatome that was associated with the latent virus
Herpes zoster (shingles)
…. disease presents with recurrent oral aphthous ulcers and two of the following features: genital ulcers, eye lesions or skin lesions
behcets
behcets disease is most commonly seen in …
middle eastern and asian young adults
…. is the most common cancer of young women and depth of invasion is the number 1 prognostic factor
malignant melanoma
characteristics of suspicious skin lesions include …
ABCDE asymmetry border color diameter enlarging
…. is the most common variant of melanoma and it has rapid growth and is clasically found on non-exposed skin
superficial spreading melanoma
…. often appears as a shiny, firm, pearly nodule with superficial telangiectasia. progression can lead to central ulceration
basal cell carcinoma
…. is the malignancy of the stratum spinosum layer of the epidermis. non-healing ulcer that often appears as an erythematous plaque. It can arise from a pre-cancerous lesion called actinic keratosis
squamous cell carcinoma
… is the most common cause of primary male hypogonadism
klinefelters syndrome (XXY)
… is due to an absent X chromosome in females. Most common cause of primary amenorrhea and is characterized by short stature, webbing of neck. Only sex aneuploidy
turners syndrome