Pathology 2 Final Flashcards
What disease is associated with a mutation in type 1 collagen?
Osteogenesis imperfecta
Give a potential diagnosis based on this xray and histological slide:
xray: multilocular radiolucency crossing midline of anterior mandible, root resorption (third molars not in yet so its a kid)
histology: multinucleated giant cells (Aka chocolate chip cookies)
Central giant cell granuloma
All of the following describe mccune Albright syndrome except:
a- cafe au lait pigmentation
b- multiple endocrine lesions
c- polyostotic disease of fibrous dysplasia
d- hypo function of cells involved in the tissues
d- hypo function of cells involved in the tissue
What is a potential diagnosis for a patient with intestinal polyps?
gardner syndrome
An immunohistochemistry test for multiple myeloma would likely present what?
monoclonal light chain
What disease is associated with amyloid deposits
multiple myeloma
What is the gene mutation for cherubim?
SH3P2
What would you expect to see under an electron microscope for langerhans cell histocytosis?
birbeck granules
What disease is commonly associated with supernumerary teeth?
Gardners syndrome
Differential diagnosis for xray:
- posterior mandible
- large well circumscribed radiolucency
- involving the roots
- tooth “Floating in air”
Langerhans cell histiocytosis
Patient is 70 years old and present with this radiograph (punched out radiolucencies all over skull). What is your diagnosis?
multiple myeloma
Upon a biopsy of a lesion, what are you expecting to find for the histology of a focal osteoporotic defect?
hematopoietic bone marrow defect
Patient presents with this lesion that hasn’t expanded in 10 years. Pulp testing reports VITAL. What is your diagnosis?
xray:
- associated with molar-premolars
- radiopacity
idiopathic ostosclerosis
- increased radiopacity, non-expansile, mandibular molar-premolar area, vital teeth
List 3 differential diagnosis for this xray:
- OKC
- Conventional amelobastoma
- Central giant cell granuloma
Radiograph of a unilocular radiolucency, what can this NOT be?
botryoid odontogenic cyst (mulilocular)
radiograph of odontoma. what cyst is most commonly associated?
Calcifying odontogenic cyst (gorlin cyst)
Histology presents a corrugated surface, prominent, palisaded, hyperchomatic basal layer. What is most likely the radiographic presentation?
multilocular radiolucency (OKC)
What is the reason for the recurrence of OKC?
satelite cysts (daughter cysts)
A 50 year old male comes in with this radiograph (huge multilocular mass in posterior mandible)
What is NOT in your differential diagnosis?
Ameloblastic fibroma because this is a “kiddie” tumor
Which of the following will you not see with nevoid basal cell carcinoma syndrome? (gorlin syndrome)
multiple ameloblastomas
you will see: bifid ribs, multiple OKCs, nervous system neoplasms (medulloblastoma)
Histology shows ghost cells, what is this?
calcifying odontogenic cyst
Patient presents with vital teeth and a radiolucency that scallops the border of the roots. On biopsy the surgeon reports and empty cavity. The patient reports having sports injury in the area.
traumatic bone cyst
What presents with normal hematopoietic bone marrow histology?
osteoprotic bone defect
Histology shows REVERSE POLARITY of basal cell nuclei, NUCLEAR HYPERCHROMATISM, NUCLEAR PALISADING, and SUBNUCLEAR VACUOLATION. What is it?
unicystic ameloblastoma
Patient presents with a lesion characterized by whirling of the epithelium and pseudo ducts. What is is?
adenomatoid odontogenic tumor
WHIRLING OF EPITHELIUM
PSEUDODUCTS
What can present as MULTIlocular radiolucency?
botryoid odontogenic cyst
Which of the following is most aggressive?
a- ameloblastic fibroma
b-complex odontoma
c- odontogenic myxoma
d- compound odontoma
c- Odontogenic myxoma
What is the least likely to be a MULTIlocular radiolucency?
periapical cyst
Histology shows PINK POLYGONAL POLYHEDRAL epithelial cells with calcifications. What is this?
Calcifying epithelial odontogenic tumor
Histology shows amyloid and Liesegang ring calficiations. What is it?
calcifying epithelial odontogenic tumor
A biopsy was done on a radiopaque lesion. Histology shows that the lesion came out whole. What is it?
cementoblastoma
Patient presents with a NON-vital tooth and radiopacity associated with the apex of the root. what is this?
condensing osteitis
What presents with multifocal radipacities?
Gardner syndrome
Picture of brown/blue teeth. Patient presents with multiple bone fractures and blue sclera. What is this?
osteogenesis imperfecta
What has a cotton wool radiographic appearance?
Paget disease of bone
What is a developmental form of a benign fibro-osseous lesion?
- Fibrous dysplasia
- osseous dysplasia
- ossifying fibroma
Which form of fibrous dysplasia involves cafe au lait pigmentation, endocrinopathy, and cranofacial dysplasia?
mccune albright syndrome
- cafe au lait pigmentation
- fibrous dysplasia
- endocrinopathy
- craniofacial dysplasia
Patient presents with a fibrous lesion. Histology reveals “Chinese-like characters”, what is it?
fibrous dysplasia
Patient presents with radiopacicites associate with the apex of several anterior mandibular teeth. The finding is incidental. What is it?
periapical cemento-osseous dysplasia
After extraction of a mandibular molar, a radiograph shows a radiopaque lesion at the extraction site. what is it?
focal cemento-osseous dysplasia
Diffuse radiopacities throughout the maxilla & mandible. What is it?
florid cemento-osseous dysplasia
A lesion is biopsied and came out in one piece. What is it?
cemento-ossifying fibroma
Patient presents with histology of extravasated RBCs, hemosiderin, and multinucleated giant cells. Blood tests revealed an increase in parathyroid hormone. What is this?
Brown tumor (central giant cell granuloma, but hyperparatyrhoidism = brown tumor)
What is the chronic focal form of langerhans cell histocytosis?
eosinophilic granuloma
localized, symmetrical widening of the PDL space is the most ominous sign of:
osteosarcoma
