Pathology 1 - Reactive lesions of the oral mucosa Flashcards
What are the cell layers of epithelium?
- stratum corneum (keratin)
- stratum granulosum
- stratum spinosum
- stratum basale
What are the gross types of oral mucosa?
- lining
- masticatory
- gustatory
Describe the appearance of nonkeratinised epithelium.
- cells are loosely bound
- stores of glycogen
Describe the appearance of keratinised epithelium.
- cells are tightly bound due to no muscles in area
- no glycogen stores
Define acanthosis.
Hyperplasia of stratum spinosum
What are elongated rete ridges?
Hyperplasia of basal cells
Define atrophy.
Reduction in viable layers
Define erosion.
Partial thickness loss
Define ulceration.
Full thickness loss with fibrin on surface
Define spongiosis.
Intercellular oedema
Define dysplasia.
Disordered maturation in a tissue
Define atypia.
Describes changes in cells
What does a dark stain within a cell indicate?
Increase in DNA within cell
What is meant by a peripheral epulides?
Originating from the gingiva, not the jaw bone
What symptoms would be cause for concern regarding malignancy and epulides?
Patient with good OH with sudden mobility of multiple teeth
Describe a giant cell epulis.
- multinucleated giant cells arranged in granulation tissue
- separated but no capsule
- bleeding is possible
What are the causes of giant cell lesions?
- unphagocytosable material
- local chronic inflammation
- infective agents (eg TB)
- hormonal stimulation of osteoclasts
- sarcoidosis
Describe how papillary hyperplasia of the palate presents on a histology slide.
Hyperplastic epithelium extends down in to underlying connective tissue
What drugs commonly cause fibrous overgrowth of the gingiva?
- calcium channel blockers
- phenytoin
- cyclosporin
How does sturge weber syndrome present?
- red vascular lesion on skin that extends along nerve branches
- can be seen intra-orally, presents with blue lesion in nerve region
Define hamartoma.
Normal tissue but greatly increased in number
