Path6 Flashcards
1
Q
Tumor Suppressor Genes and Cancer.
A
Loss of Function -> INcreased cancer risk
Both Alleles must be lost for expression of disease
2
Q
Tumor Suppressor Genes. (12)
A
Rb p53 BRCA1 BRCA2 p16 BRAF APC or B-Catenin WT1 NF1 NF2 DPC4 DCC
3
Q
Retinoblastoma & Osteosarcoma
A
Gene: Rb
- Inhibits E2F
- Blocks G1 -> S phase
4
Q
Most human cancers, Li-Fraumeni syndrome
A
Gene: p53
- Transcription factor for p21
- Blocks G1 to S phase
5
Q
Breast and ovarian Cancer
A
Gene: BRCA 1&2
- DNA repair protein
6
Q
Melanoma
A
Gene: BRAF & p16
- B-raf
7
Q
Colorectal cancer (associated with FAP)
A
Gene: APC or B catenin
8
Q
Wilms’ tumor (nephroblastoma)
A
Gene: WT1
9
Q
Neurofibromatosis Type 1
A
Gene: NF1
- RAS GTPase activating protein (RAS-GAP)
10
Q
Neurofibromatosis Type 2
A
Gene: NF2
- Merlin (schwannomin) protein
11
Q
Pancreatic Cancer
A
Gene: DPC4
- DPC - Deleted in Pancreatic Cancer
12
Q
Colon Cancer
A
Gene: DCC
- DCC - Deleted in Colon Cancer
