Path5

Question 1

Oncogenes and cancer.

Answer 1

Gain of function -> INcreased cancer risk

Need damage to only 1 allele

Question 2

Oncogenes. (9)

Answer 2

abl
c-myc
bcl-2
HER2/neu (c-erbB2)
ras
L-myc
N-myc
ret
c-kit

Question 3

CML

Answer 3

Gene: abl

- Tyrosine Kinase

Question 4

Burkitt’s lymphoma

Answer 4

Gene: c-myc

- Transcription factor

Question 5

Follicular and Undifferentiated Lymphomas

Answer 5

Gene: bcl-2

- Anti-Apoptotic molecule

Question 6

Breast, Ovarian, & Gastric Carcinomas

Answer 6

Gene: HER2/neu (c-erbB2)

- Tyrosine kinase

Question 7

Colon Carcinoma

Answer 7

Gene: ras

- Tyrosine kinase

Question 8

Lung tumor

Answer 8

Gene: L-myc

- Transcription Factor

Question 9

Neuroblastoma

Answer 9

Gene: N-myc

- Transcription Factor

Question 10

Multiple Endocrine Neoplasia (MEN) 2A & 2B

Answer 10

Gene: ret

- Tyrosine Kinase

Question 11

Gastrointestinal Stromal Tumor (GIST)

Answer 11

Gene: c-kit

- Cytokine receptor

Question 12

What oncogenes produce Tyrosine Kinase?

Answer 12

abl (CML)
HER2/neu (c-erbB2) (breast, ovarian, gastric)
ret (MEN 2A & 2B)

Question 13

What oncogenes produce Transcription factors?

Answer 13

c-myc (Burkitt’s)
L-myc (Lung)
N-myc (Neuroblastoma)

Question 14

What proto-oncogene linked to Small cell carcinoma?

Answer 14

N-Myc

Question 15

what proto-oncogene linked to squamous cell carcinoma?

Answer 15

ERB-B1

Question 16

SIS proto-oncogene

Answer 16

astrocytoma and osteosarcome