Path10

Question 1

ACTH or ACTH-like peptide

Answer 1

Neoplasm:
- Small Cell Lung Cancer
Effect:
- Cushing’s syndrome

Question 2

ADH

Answer 2

Neoplasm:
 - Small cell lung carcinoma
 - Intracranial neoplasms
Effect:
 - SIADH

Question 3

PTHrP

Answer 3

Neoplasm:
 - Squamous Cell Lung Carcinoma
 - Renal cell carcinoma
 - Breast cancer
Effect:
 - Hypercalcemia

Question 4

1,25-(OH)2 D3 (Calcitriol)

Answer 4

Neoplasm:
 - Hodgkin's lymphoma
 - some Non-Hodgkin's lymphomas
Effect:
 - Hypercalcemia

Question 5

Erythropoietin

Answer 5

Neoplasm:
 - Renal cell carcinoma
 - Hemangioblastoma
 - Hepatocellular carcinoma
 - Pheochromocytoma
Effect:
 - Polycythemia

Question 6

Abs vs. presynaptic Ca++ channels at NMJ

Answer 6

Neoplasm:
- Small cell lung cancer
Effect:
- Lambert-Eaton syndrome (muscle weakness)

Question 7

Small Cell Lung Carcinoma - Paraneoplastic Syndromes

Answer 7

ACTH (Cushing’s)
ADH (SIADH)
Abs vs. presynaptic Ca++ channels (Lambert-Eaton syndrome)

Question 8

Renal Cell Carcinoma - Paraneoplastic Syndromes

Answer 8

PTHrP (Hypercalcemia)

Erythropoietin (Polycythemia)

Question 9

What are Psammoma bodies?

Answer 9

Laminated, concentric, calcific spherules

Question 10

What are psammoma bodies seen?

Answer 10

• Papillary Adenocarcinoma of Thyroid
• Serous Papillary cystadenocarcinoma of Ovary
• Meningioma
• Malignant Mesothelioma

“PSaMMoma”