PATH: Intracellular Pathological Accumulations Flashcards
What is the difference between microvesicular fat and macrovesicular fat?
Fat accumulations typically begin as multiple small droplets, which is microvascular, that eventually coalescence into a large, single droplet (macrovesicular)
What two uncommon diseases are characterized by the presence of microvesicular fat only?
Reyes Syndrome and Acute Fatty Liver of Pregnancy
What are macrophages that take in a large amount of lipids and cholesterol?
Foamy cells
What are two examples of pathologic protein accumulations?
Protein resorption droplets in renal tubular epithelial cells, and Alpha 1-Antitrypsin disease
How is iron stored under normal and pathologic conditions?
Normally it is stored in the form of ferritin, but when Fe undergoes autophagy it turns into hemosiderin
What type of intracellular accumulation will stain brightly with Prussian blue?
Hemosiderin
What are conditions in which iron accumulates?
Diseases of abnormally formed RBCs or requiring numerous transfusions; Phagocytosed RBCs results in excess Fe accumulation
What is hemochromatosis?
Autosomal recessive disorder of Fe absorption (increased uptake)
What is the only mechanism of Cu excretion from the body?
Through bile
What is the autosomal recessive disease in which Cu accumulates?
Wilson’s disease
The deposition of what causes jaundice?
Bilirubin
What intracellular accumulation represents the final product of free-radical damage of membranes?
Lipofuscin
What is dystrophic calcification?
Deposition of calcium in necrotic or chronically traumatized tissue
What is metastatic calcification?
Deposition of calcium salts in viable tissue in conditions of high serum calcium levels
