PATH: Chronic Inflammation

Question 1

What are the three possible outcomes of acute inflammation?

Answer 1

1- complete resolution with regeneration 2- healing by connective tissue replacement or 3- progression to chronic inflammation

Question 2

What are the general categories of chronic inflammation etiology?

Answer 2

1) persistence infection 2) immune-mediated inflammatory disease or 3) prolonged exposure to toxins

Question 3

What cells are involved in chronic inflammation?

Answer 3

Macrophages, lymphocytes, plasma cells, eosinophils, mast cells, neutrophils, and giant cells

Question 4

What is the half-life of tissue macrophages?

Answer 4

Months to years

Question 5

True or false: features of acute and chronic inflammation may co-exist.

Answer 5

True

Question 6

What is granulamatous inflammation?

Answer 6

A granuloma is a focus of chronic inflammation consisting of a mcroscopic aggregation of macrophages that are transformed into epithelium-like cells, surrounded by a collar of mononuclear leukocyte (lymphocytes and plasma cells)

Question 7

What Leukocytosis occurs due to a bacterial infection? A viral infection?

Answer 7

Neutrophlia; Lymphocytosis