Past qs June 2019

Question 1

WHAT CAN BE SAID ABOUT THE ACCUMULATION PROPERTIES OF A SUBSTANCE, IF ACUTE LD50 VALUE IS 5.6MG/KG, AND 90 DAYS CONTINUOUS LD50 VALUE IS 0.8 MG/KG? (2 points)

Answer 1

RELATIVELY CUMULATIVE

Question 2

COMPLETE MISSING SPACES IN THE TABLE (6 points)

1. Dimercaprol
2. CaNa2-EDTA
   - Type of metal poisoning
   - Dose
   - Administration route

Answer 2

1. Dimercaprol
   - As, Hg
   - 3-5 mg/kg
   - IM 4x/day
2. CaNa2-EDTA
   - Pb + Zi / Co
   - 50-100 mg/kg / 20-50 mg/kg
   - IV 3-4x/day

Question 3

COMPLETE THE FOLLOWING SENTENCES (4points)

• The specific antidote of metaldehyde toxicosis .. ?…
• Excitation, convulsion can be alleviated with (1)…?… (2)…?…
• Acidosis can be treated with IV …? …

Answer 3

• The specific antidote of metaldehyde toxicosis …NO SPECIFIC ANTIDOTE …
• Excitation, convulsion can be alleviated with (1) …PROPOFOL … (2) … DIAZEPAM…
• Acidosis can be treated with IV …SODIUM BICARBONATE …

Question 4

IT IS ASSUMED THAT BIPYRIDYL TOXICOSIS KILLED A FEW FARM ANIMALS. HOW CAN YOU FIND OUT IF OTHER ANIMALS ARE POISONED WITH THESE … AGENTS? ANIMALS HAVE NOT BEEN SHOWING RESPIRATORY SIGNS YET. (4 points)

• Name of test to be applied: ?
• How long can the test be used after toxicosis?
• Which colours can be seen in the urine in case of dipyridil poisoning?

Answer 4

• Name of test to be applied: TOMPSETT TEST (1ml urine + 1 ml 1%Na-dithionate in NaOH)
• How long can the test be used after toxicosis: < 48
• Which colours can be seen in the urine in case of dipyridil poisoning: Paraquat blue, Diquat green

Question 5

WHICH PLANT? (2points)

1. This garden plant contains indole alkaloids. Its seeds are toxic. It is hallucinogenic.
2. This plant contains piperidine alkaloids and it has an unpleasant mouse urine-like smell. It causes ascending paralysis.

Answer 5

1. This garden plant contains indole alkaloids. Its seeds are toxic. It is hallucinogenic. BLUE STAR
2. This plant contains piperidine alkaloids and it has an unpleasant mouse urine-like smell. It causes ascending paralysis HEMLOCK

Question 6

COMPLETE THE SENTENCES! (1 POINT/RIGHT ANSWER)

• In theophylline poisoning, the urinary pH has to be …?… to enhance elimination , and for this purpose, we can apply …?…
• In atropine poisoning, the urinary pH has to be …?…to enhance elimination , and for this purpose, we can apply… ?…
• In muscarine poisoning, urinary pH has to be …?… to enhance elimination, and for this purpose we can apply ..?…
• In scopolamine poisoning, urinary pH has to be …?… to enhance elimination, and for this purpose we can apply … ?…

Answer 6

• In theophylline poisoning, the urinary pH has to be …acidified… to enhance elimination , and for this purpose, we can apply …vit C…
• In atropine poisoning, the urinary pH has to be …acidified…to enhance elimination , and for this purpose, we can apply… Vit C…
• In muscarine poisoning, urinary pH has to be …acidified… to enhance elimination, and for this purpose we can apply …Vit C…
• In scopolamine poisoning, urinary pH has to be … acidified… to enhance elimination, and for this purpose we can apply … Vit C…