Past q 2 (midterm 1) Flashcards
According to the theory that agonists and antagonists occupy the same receptor site, an effective antagonist should exhibit
A.High intrinsicactivity and low affinity
B.No intrinsic activity and high affinity
C.Low intrinsic activityand low affinity
D.High intrinsic activity and high affinity
B.No intrinsic activity and high affinity
A drug that interacts directly with the agonist and not at all, or only incidentally with the receptor A.Chemical antagonist B.Pharmacological antagonist C.Partial agonist D.Physiologic antagonist
A.Chemical antagonist
\_\_\_the largest effect a drug can produce, regardless of dose A.Quantal dose response curve B.Graded dose response curve C.Maximum efficacy D.Therapeutic index
C.Maximum efficacy
What is approximate percentage of a weak base (pKa = 8.4) in the non-ionised form in the plasma having a pH of 7.4? A.90% B.50% C.100% D.10%
D.10%
When supplying this drug, one copy of which of the following has to be kept by the registered feed compounder?
A.Prescription
B.Special prescription
C.Prescription for medicated feedstuff (PMF)
D.Legislation on requisition
C.Prescription for medicated feedstuff (PMF)
Which of the following can occur at therapeutic dosage levels in healthy patients? A.Allergic reactions B.Teratogenic effects(Thalidomide) C.Idiosyncratic reactions D.All of the above can occur
D.All of the above can occur
Examine the graph: what is the potency relationship between drug A and B? A.Conclusion cannot be drawn B.B is more potent C.They are of equal potency D.A is more potent(first on the graph)
D.A is more potent(first on the graph)
A drug licensed for humans and included in Table 1, and MRL has to be established administered to dairy cattle should have a withdrawal period for milk A.At most 7 days withdrawal period B.At most 28 days withdrawal period C.At least 28 days withdrawal period D.At least 7 days withdrawal period
D.At least 7 days withdrawal period
According to this type of medicinal substance use both sick and healthy animals are treated with a mass (population)administration: A.Metaphylaxis B.Mass treatment C.Always D.Prophylaxis
A.Metaphylaxis
What is the proportion of ionised and non-ionised molecules of a weak acidic drug (pKa= 4.4) in blood (pH = 7.4)! A.1:1 B.100:1 C.10:1 D.1000:1
D.1000:1
How long do the withdrawal period usually last at minimum for meat, following application of a human licensed medicine? A.7 days B.500 degree days C.28 days D.0 days
C.28 days
How long dothe withdrawal period usually last for fish at minimum, following application of a human licensed medicine? A.28 days B.500 degree days C.0 days D.7 days
B.500 degree days
The phenomenon in which two drugs produce opposite effects on a physiologic system but do not act at the same receptor site is: A.Chemical antagonism B.Physiologic antagonism C.Competitiveantagonism D.Non-competitiveantagonism
B.Physiologic antagonism
Two drugs A and B, have the same mechanism of action. Drug A in a dose of 5 mg produces the same magnitude of effect as drug B in a dose of 500 mg
A.Drug B is less efficacious than drug A
B.The toxicity of drug A is lower than that of drug B
C.Drug A is 100 times more potent than drug B
D.Drug A has a shorter duration of action
C.Drug A is 100 times more potent than drug B
Which substance is a schedule2 substance? A.Cannabis B.Fentanyl C.Diazepam D.Phenobarbital
B.Fentanyl
Qualitative and quantitative determination of the medicinal substances is not introduced in A.British Veterinary Formulary B.Hungarian Pharmacopeia C.European Pharmacopeia D.British Pharmacopeia
A.British Veterinary Formulary
The LD50 of a drug is
A.50% of the lethal dose in man
B.50% of the lethal dose in an experimental animal
C.The dose (mg/kg) that kills 50% of the treated animals
D.Half the dose that kills all of the treated animals
C.The dose (mg/kg) that kills 50% of the treated animals
Among the environmentalfactors that may harm the medicines,this stimulates theoxidation or reduction processes: A.Fungi B.Humidity C.Light (UV) D.Heat
C.Light (UV)
This category may play an important role in prevention of animal disease, but they are not real drugs: A.Prepared drugs B.Immunologicals C.Official drugs D.Biocides
D.Biocides
How long do the withdrawal period usually last for eggs, following application of an official or prepared medicine A.500 degree days B.0 days C.28 days D.7 days
D.7 days
Which temperature interval is valid if the drug has to be stored at a cool place? A.15 –25°C B.2 –8°C C.8 –15°C D.10 –14°C
C.8 –15°C
What is written in the inscription in case of prepared preparations?
A.The name and amount of the ingredients
B.The name,dosage form and the strength of preparation
C.The dosage form and the container
D.The number of original packages
A.The name and amount of the ingredients
What "Medicines order 2001 UK" categorycan be supplied by pharmacistswithoutany prescription? A.P and PML B.GSL, P, PML C.GSL and P D.Every "medicines order 2001" category
B.GSL, P, PML
Quantal dose response curves are
A.Invalid in the presence of inhibitors of the drug studied
B.Used for determining the maximal efficacy of a drug
C.Obtainable from the study of intact subjects butnot from isolated tissues
D.Used in determining the therapeutic index of a drug
D.Used in determining the therapeutic index of a drug
This name of medicinal substances is given by the pharmacopeia commission to each compound: A.Chemical name B.Each drug name C.Proprietary name D.Approved name
D.Approved name
Which part of the prescription gives the farmer information on the withdrawal time A.Subscription B.Signature C.Superscription D.Inscription
B.Signature
Which effect facilitates the oral bioavailability of medicinal products? A.Acid sensitivity of drug B.Increased motility of GI C.Large pKa value of drug D.Rapid dissolution from the formulation
D.Rapid dissolution from the formulation
Which is an example for substitution therapy
A.Administration of thyroxin for the treatment of hyperthyroidism
B.Administration of a generic drug instead of original licensed product
C.Administration of thyroxin for the treatment of hypothyroidism
D.During antimicrobial treatment switching the antibiotic in case of resistant strain appearance
C.Administration of thyroxin for the treatment of hypothyroidism
Which statement is NOT true for a first order, one compartment open pharmacokinetic model?
A. A bio exponential curve is used to describe the decrease of the drug level in time
B.In the course of this process the capacity of organs of metabolism and or excretion is saturated
C.After a single drug administration the drug is eliminated from the body continuously
D.The drug is distributed among the tissues of the body evenly
B.In the course of this process the capacity of organs of metabolism and or excretion is saturated
A drug that mediates the reversal of histamine bronchoconstriction (mediated at histamine receptors) by acting at adrenoceptors (e.g.epinephrine) A.Pharmacological antagonist B.Physiologic antagonist C.Non-competitive antagonist D.Partial agonist
B.Physiologic antagonist
What is characteristic for a drug molecule, which has been metabolised in the Phase II of biotransformation procedure?
A.Losing of activity
B.Active metabolite from an inactive pro-drug
C.Metabolite with qualitatively different pharmacologic action
D.Increased activity
A.Losing of activity
Drug allergies
A.Can develop when the patient may or may not have been exposed to the drug previously
B.Are more likely develop in a very young infant
C.Can develop only when the patient has previously received the drug
D.Are more likely to develop in a very old animal
A.Can develop when the patient may or may not have been exposed to the drug previously
When comparing drugs with respect to intensity of response, the drug that produces the greatest maximum effect is the one with the highest A.Affinity B.Therapeutic index C.Efficacy D.Potency
C.Efficacy
The pharmacist can supply these drugs only if presented with a valid prescription from the practitioner:
A.Pharmacy and merchant list medicines (PML)
B.General sales list meds (GSL)
C.Pharmacy medicines (P)
D.Prescription only medicines (POM)
D.Prescription only medicines (POM)
The effect and side effects of drugs, as well as the contraindications of their uses areNOT introduced well detailed in: A.British Veterinary Formulary B.European Pharmacopeia C.Vademecum D.Drug lexicon
B.European Pharmacopeia
The category drug like substances (non real drugs) includes: A.Official drugs B.Prepared drugs C.Immunologicals D.Biocides
D.Biocides
Which part of the prescription tells the pharmacist the name and formulation of the drug: A.Signature B.Superscription C.Inscription D.Subscription
C.Inscription
The oral AUC is the half that of the IV AUC value and for oral administration two fold higher dose was used. What is the bioavailability (F) value of the drug? A.0.5 B.0.1 C.0.125 D.0.25
D.0.25
The results shown in the graph were obtained in a comparison of positive inotropic agents
A.Drug A is most effective
B.Drug B is least potent
C.Drug A is more potent than drug B and more effective than drug C
D.Drug B is more potent than drug C and more effective than drug A
D.Drug B is more potent than drug C and more effective than drug A(høyere enn A og før C på grafen)
Which of the following is an action of a non-competitive antagonist?
A.Alters the mechanism of action of an agonist
B.Alters the potency of an agonist
C.Decreases the maximum response to an agonist
D.Binds to the same site on the receptor as the agonist
C.Decreases the maximum response to an agonist
Drugs may harmfully interact with useful intestinal microbes. In which species is the effect the least significant A.Hamsters B.Horses C.Rabbits D.Dogs
D.Doggos
If drug A has a greater efficacy than drug B, then drug A
A.Is more toxic than drug B
B.Has a greater affinity for the receptor than drug B
C.Is capable of producing a greater maximum effect than drug B
D.Has a greater margin of safety than drug B
C.Is capable of producing a greater maximum effect than drug B
A drug that blocks the action of epinephrine at its receptors by occupying those receptors without activating them A.Chemical antagonist B.Pharmacological antagonist C.Partial agonist D.Physiologic antagonist
B.Pharmacological antagonist
In this type of prescription the proprietary name of a vet-licensed medicine is given
A.Prescription of a veterinary licensed medicine
B.Prescription of a formulated official medicine
C.Prescription of a prepared (magistral) medicine
D.Prescription of a human licensed medicine
A.Prescription of a veterinary licensed medicine
Which one is incorrect? Factors maintaining drug allergy are:
A.Contamination of skin
B.Inhalation –contamination of airways
C.Preparation with rapid absorption after IM or SC administration
D.Chronic disease, atrophy
C.Preparation with rapid absorption after IM or SC administration
The major part of the text must be in the veterinarian’s own handwriting:
A.Special preparation
B.Label
C.Prescription
D.Prescription for medicated feedstuff (PMF)
A.Special preparation
This name of medicinal substances is given by the manufacturers A.Each drug name B.Approved name C.Chemical name D.Proprietary name
D.Proprietary name
The oral AUC is the 25% of that of the IV AUC value and for IV administration two foldhigher dose was used. What is the bioavailability (F) value of the drug A.0.75 B.0.5 C.0.25 D.0.125
B.0.5
Which part of the prescription gives the owner information about the dosages of an animal A.Signature B.Inscription C.Superscription D.Subscription
A.Signature
Mark the reaction, which is not characteristic for Type I, immediate or anaphylactic drug allergy reaction: A.Immune complex formation B.Urticaria C.Asthma like condition D.Oedema
A.Immune complex formation
A drug licensed for humans and included in Annex I and III administered to dairy cattle should have a withdrawal period for milk: A.At most 7 days withdrawal period B.At most 28 days withdrawal period C.At least 28 days withdrawal period D.At least 7 days withdrawal period
D.At least 7 days withdrawal period
Vehicle in licking stones: A.Light kaolin B.Activated charcoal C.Sodium chloride D.Bismuth subgallate
C.Sodium chloride
How long do the withdrawal period usually last for fish at minimum, following application of an official or prepared medicine? A.7 days B.0 days C.500 degree days D.28 days
C.500 degree days
For which category is not true, usually it develops after repeated administration? A.Drug tolerance B.Idiosyncrasy C.Drug allergy D.Drug dependence
B.Idiosyncrasy
Which substance is a schedule 3 substance A.Phenolbarbital/phenobarbitone B.LSD C.Morphine D.Fentanyl
A.Phenolbarbital/phenobarbitone
Which drug has to be kept in a locked receptacle with the key in the possession of the veterinarian? A.Schedule 3 and 4 drugs B.Schedule 1 and 4 drugs C.None of these D.Schedule 2 and 3
D.Schedule 2 and 3
A dosage form appropriate for the preparation of medicated feedstuff: A.Premix B.OROS C.WSP D.Oral solution
A.Premix
Specific receptor antagonists can best be described as having
A.Affinity but little or no efficacy for the receptor
B.Both efficacy and affinity for the receptor
C.Efficacy but little or no affinity for the receptor
D.None of the above
A.Affinity but little or no efficacy for the receptor
Antagonists are drugs that
A.Bound passively to the tissue receptor site
B.Reserve the effect of other drugs on tissue receptor sites
C.Activate tissue receptor sites
D.Block tissue receptor sites
D.Block tissue receptor sites
Defined as treatment of clinically diseased animals and prevention of spreading diseases in herd: A.Panphylaxis B.Anaphylaxis C.Prophylaxis D.Metaphylaxis
D.Metaphylaxis
Which statement is not true for a first order, open compartment open pharma …model?
A.A bio exponential curve is used to describe the decrease of the drug level in time
B.After a single drug administration the drug is eliminated from the body continuously
C.In the course of this process the capacity of organs of metabolism and or excretion is saturated
D.The drug is distributed among the tissues of the body evenly
C.In the course of this process the capacity of organs of metabolism and or excretion is saturated
Drugs can be used as non-divided powders:
A.Only drugs with broad therapeutic margin
B.Only drugs for the treatment of poultry
C.Only water insoluble drugs
D.Only water soluble drugs
A.Only drugs with broad therapeutic margin
These drugs are always POM medicines A.Premixes B.Controlled drugs C.Official preparations D.Non steroidal anti inflammatory drugs
B.Controlled drugs
Examine the graph:what is the efficacy relationship between drug A and C? A.A is more efficious B.Conclusion cannot be drawn C.C is more efficacious D.They are of equal efficacy
A.A is more efficious(A er høyere og før C i grafen)
Which technology is appropriate for achieving a pulsatile release of an active substance in a bolus A.OROS B.Insoluble matrix C.Chip controlled diaphragm D.Expanding matrix
C.Chip controlled diaphragm
Which effect facilitates the oral bioavailability of medicinal products? A.Rapid dissolution from the formulation B.Increased motility of GI C.Acid sensitivity of drug D.Large pKa value of drug
A.Rapid dissolution from the formulation
Which ingredient is missing from the hard capsule A.Gelatine B.Glycerine C.Water D.Sugar
B.Glycerine
These drugs are natural compounds of practically harmless substances, which do not require a withdrawal period A.Drugs in Annex II B.Drugs in Annex I C.Drugs in Annex III D.Drugs in Annex IV
A.Drugs in Annex II
When are written special prescriptions and written requisitions mandatory? A.Schedule 3 and 4 drugs B.Schedule 1 and 4 drugs C.Schedule 2 and 3 drugs D.None of them above
C.Schedule 2 and 3 drugs
At steady state the plasma concentration of a drug (Cpss) is 1 mg/L. The total body clearance is (Cl2) 100 ml/min. What is the maintenance dose if the drug is applied in every 12 hour? A.7.2 mg B.72 mg C.50 mg D.100 mg
B.72 mg
A drug licensed for humans containing metronidazole
A.Has to have at least 28 WP for meat
B.Must not be used in food producing animals
C.Cannot penetrate into the milk thus no WP for milk has to be stated
D.Requires 0 days WP in food producing animals
B.Must not be used in food producing animals
A drug included in 2377/790EEC Annex II has a withdrawal period of:
A.7days
B.Must not be administrated to food producing animals
C.0 days
D.28 days
C.0 days
Which drugs are normally not used in the veterinary practice? A.Schedule 1 drugs B.Schedule 2 drugs C.Schedule 3 drugs D.Schedule 4 drugs
A.Schedule 1 drugs
What information about any drug is included in the European Pharmacopeia’s? A.Indication in veterinary medicine B.Identification methods C.Dosage of the drug in humans D.Indications in human medicine
B.Identification methods
In this type of prescription the name and amount of ingredients (individual components) has to be given in the inscription part
A.Prescription of a human licensed medicine
B.Prescription of a veterinary licensed medicine
C.Prescription of a formulate official medicine
D.Prescription of a prepared (magistral) medicine
D.Prescription of a prepared (magistral) medicine
How long after the first use can drugs from multi dose injection bottles be used? A.At most 14 days B.At most 28 days C.At most 7 days D.No such requirement is official
B.At most 28 days
Which of the following is the licensed name of the drug
A.Amoxicillin
B.7-amino-3,3-dimethyl-oxo-4-carboxylic acid
C.Betamox inj AUV
D.None of them above
C.Betamox inj AUV
The most frequent active ingredient of intraruminal boluses A.NSAID B.Anthelminthic C.Growth promotor D.Antibiotics
B.Anthelminthic
Which active substance is appropriate for analgesia (painkiller) as a transdermal patch? A.Fentanyl B.Naloxone C.Metamizole D.Butorphanol
A.Fentanyl
A drug licensed for humans and included in Annex I, administrated to dairy cattle’s should have a WP of at least A.At most 28 days WP B.At least 28 days WP C.At most 7 days WP D.At least 7 days WP
D.At least 7 days WP
In figure 1, three different doses of drug A are tested for activity. In figure 2, three doses of drug B are tested for activity in the same test system. In figure 3, three doses of drug A are tested in the presence of the high dose of drug B. based upon the responses seen, which of the following statements best describe drugs A and B?
A.Drug A is an antagonist; drug B is neither an agonist nor antagonist
B.Drug A is a partial agonist; drug B is an antagonist
C.Drug A is an antagonist; drug B is an agonist
D.Drug A is an agonist; drug B is a partial agonist
A.Drug A is an antagonist; drug B is neither an agonist nor antagonist (drug B synes ikke på grafen)
