Past q 1(midterm 1) Flashcards
Which of the following can occur at therapeutic dosage levels in healthy patients?
a. All of the above can occur
b. Allergic reactions
c. Teratogenic effects
d. Idiosyncratic reactions
a.All of the above can occur
MRL is an acronym for
a. Minimum relevant level
b. Maximum residue limit
c. Medicine residue level
d. Medicine registry list
b.Maximum residue limit
Usually for mixing these types of real drugs into the medicated feedstuff, commercial feed compounders need to have a Prescription for Medicated Feedstuff (Veterinary Written Direction)
a. POM-V
b. Pharmacy medicines (P)
c. Prescription only medicines (POM)
d. AVM-GSL
a.POM-V
Quantal dose response curves are
a. Obtainable from the study of intact subjects but not from isolated tissues
b. Used for determining the maximal efficacy of a drug
c. Used in determining the therapeutic index of a drug
d. Invalid in the presence of inhibitors of the drug studied
c.Used in determining the therapeutic index of a drug
The adhesive of the granules can be
a. Pyridine
b. Saccharose
c. Distilled water
d. Lactose
c.Distilled water
Which drugs have to be kept in a locked receptacle with the key in possessionof the veterinarian?
a. Schedule 2 and 3 drugs
b. None of these
c. Schedule 1 and 4 drugs
d. Schedule 3 ad 4 drugs
a.Schedule 2 and 3 drugs
What is the first pass effect?
a. High plasma concentration occurs immediately after oral application
b. Stomach accumulates the drug
c. Liver decomposes the orally applied drug
d. Kidneys excrete the orally applied drug
c.Liver decomposes the orally applied drug
In which book can the indications, effects, and side effects of a given drug be found?
a. U.S. Pharmacopoeia
b. European Pharmacopoeia
c. British Veterinary Formulary
d. British Pharmecopoeia Veterinary
c.British Veterinary Formulary
The capacity of a drug to cause a particular action
a. Affinity
b. Specificity
c. Selectivity
d. Efficacy
b.Specificity
A drug that mediates the reversal of histamine bronchoconstriction (mediated at the histamine receptors) by acting at adrenoceptors (e.g. epinephrine).
a. Partial agonist
b. Noncompetitive antagonist
c. Physiologic antagonist
d. Pharmacologic antagonist
c.Physiologic antagonist
Sublingual administration is useful for
a. Drugs causing nausea or vomiting
b. Drugs with high first pass metabolism
c. Hydrophilic drugs
d. Drugs that do not readily cross the blood brain barrier
b.Drugs with high first pass metabolism
Which is the most informative name of drug about the major ingredient?
a. Approved name
b. Proprietary name
c. Chemical name
d. Licensed name
a.Approved name
Which effect facilitates the oral bioavailability of medicinal products?
a. Large pKa value of the drug
b. Increased motility of GI
c. Acid sensitivity of the drug
d. Rapid dissolution from the formulation
d.Rapid dissolution from the formulation
According to the Misuse of Drug Regulations (UK) this drug is in Schedule 3
a. Pentobarbitone
b. Low amount of codeine
c. Morphine
d. Ketamine
a.Pentobarbitone
The maximal activity specific to a drug
a. Specificity
b. Potency
c. Intrinsic activity
d. Affinity
c.Intrinsic activity
Records should be made within 48 hours of the transaction and kept for a period of at least 5 years
a. Records of POM treatments
b. Records on scheduled drug treatments
c. Records on food producing animal treatments
d. Records on all treatments
c.Records on food producing animal treatments
Which technology is appropriate for achieving a pulsatile release of an active substance in a bolus?
a. Insoluble matrix
b. Chip controlled diaphragms
c. Expanding matrix
d. OROS
b.Chip controlled diaphragms
Solid, single dose or multidose preparation for oral administration containing dry aggregates of powder particles
a. Oral powder
b. Premix
c. Capsules
d. Granules
d.Granules
What is the proportion of ionized vs non ionized molecules of a weak basic drug (pKa=7.4)in stomach (PH=3.4)?
a. 10:1
b. 1:1
c. 10,000:1
d. 100:1
c.10,000:1
What “veterinarymedicines regulation 2013”category can be supplied by pharmacists without prescription?
a. POM-VPS and AVM-GSL
b. POM-VPS, NFA-VPS
c. NFA-VPS, AVM GSL
d. Every “Veterinary medicines regulation 2013”category
c.NFA-VPS, AVM GSL
This is the name given to a drug by manufacturers that produce the drug
a. Approved name
b. Proprietary name
c. None of these
d. Chemical name
b.Proprietary name
Most appropriate methodfor the extraction of water soluble, heat sensitive substances from medicinal herbs
a. Preparing an infusion
b. Extraction with ether
c. Making a decoction
d. Preparing a tincture
b.Extraction with ether
Which process can move drugs against a concentration gradient?
a. Active transport
b. Filtration through membrane pores
c. Simple diffusion
d. Facilitated diffusion
a.Active transport
Two drugs have been examined in animal studies, Both have a therapeutic index of 2. It can be assumed that:
a. The dose response curves will be parallel
b. None of these
c. When given in ED50 does, the two drugs are equally safe
d. When ive at ED50 does, no animals will be killed by the drugs
b.None of these