Parvovirus in pregnancy

Question 1

What percent of adults are immune to parvovirus?

Answer 1

50%

Question 2

What is the route of transmission of Parvovirus?

Answer 2

blood borne, respiratory

Question 3

Constitutional symptoms usually begin on what day following inoculation ?

Answer 3

Day 6-9

Question 4

Viremia usually begin on what day following inoculation ?

Answer 4

Day 6-13

Question 5

IgM becomes positive on what day following inoculation ?

Answer 5

Day 13 to 3 months

Question 6

cheek rash usually begins on what day following inoculation ?

Answer 6

Day 18 - 21

Question 7

When does IgG become positive for Parvovirus?

Answer 7

21 days - Lifelong

Question 8

IgG negative and IgM negative indicates what type of condition for Parvo?

Answer 8

Susceptible

Question 9

IgG positive and IgM negative indicates what type of condition for Parvo?

Answer 9

Immune, Infection > 120 days ago

Question 10

IgG negative and IgM positive indicates what type of condition for Parvo?

Answer 10

Acute infection within 7 days

Question 11

IgG positive and IgM positive indicates what type of condition for Parvo?

Answer 11

Infection between 7 days - 120 days

Question 12

If you have a patient with known parvo exposure BUT negative IgG and IgM, what is the next best course of action?

Answer 12

Repeat Serology in 3 weeks

Question 13

What is the overall rate of vertical transmission for parvo-virus?

Answer 13

33%

Question 14

In the fetus what tissues are most affected by parvovirus?

Answer 14

Cardiac muscle and RBC precursors

Question 15

What is the primary fetal risk of Parvo infection?

Answer 15

Hydrops

Question 16

What is the risk of fetal hydrops with parvo infection?

Answer 16

5-20%

Question 17

When does fetal hydrops occur in relation to maternal infection?

Answer 17

within 4-6 weeks of maternal infection

Question 18

How should a fetus be managed with known maternal exposure and infection?

Answer 18

Weekly US for hydrops starting in the second trimester and continued 8 - 12 weeks following maternal exposure