Parvoviridae

Question 1

Parvoviridae characteristics

Answer 1

nonenveloped, icosahedral, T=1

linear, single-stranded DNA, very stable

Question 2

Parvoviridae replication occurs in ___

Answer 2

the nucleus of dividing cells (during S phase), leads to large intranuclear inclusion bodies

Question 3

5 genera of parvovirinae

Answer 3

Parvovirus, Erythrovirus, Dependovirus, Bocavirus, Amdovirus

Question 4

Erythrovirus causes __

Answer 4

Slap cheek rash, fifth disease

Question 5

Slap cheek rash in humans is caused by parvovirus type ___

Answer 5

B19

No transmission btw humans and cats/dogs

Question 6

Slap cheek rash: Clinical signs

Answer 6

mild rash, aplastic anemia, painful joints

Question 7

Dependovirus must have a helper virus to replicate, this is usually ___

Answer 7

adenovirus

Question 8

Bocavirus contains an ___ btw non-structural and structural coding regions

Answer 8

3rd open reading frame

Question 9

Feline parvovirus is known as Feline ____

Answer 9

Feline panleukopenia (FPV)

Question 10

T or F

Nearly all cats are infected with FPV within the first year of life

Answer 10

True

Question 11

FPV: transmission

Answer 11

direct contact with secretions, feces, fomites
in-utero
mechanical transmission

Question 12

FPV replication first occurs in ___ (organ)

Answer 12

pharyngeal lymphoid tissue

Question 13

FPV: pathogenesis

Answer 13

destroys all WBC and lymphoid tissues
thrombocytopenia
enteritis

Question 14

FPV: In-utero clinical signs

Answer 14

Early- fetal reabsorption, abortion, mummies

Late- live kittens with neural damage, CNS, ocular damage, cerebellar hypoplasia, hydranecephaly

Question 15

FPV: clinical signs in adults

Answer 15

fever, depression, anorecia, rough coat, vomiting, diarrhea, severe dehydration, hypothermia, DIC, death

Question 16

T or F

you can vaccinate pregnant queens for FPV

Answer 16

False
May cause abortion, mummies, infertility
cerebellar hypoplasia and retinal damage in kittens

Question 17

FPV: diagnosis

Answer 17

clinical signs, necropsy, hematology, virus isolation, serology
fecal viral antigen using immunochromatography
PCR, direct hemagglutination

Question 18

FPV: treatment

Answer 18

supportive care, broad spectrum antibodies

Question 19

FPV: control

Answer 19

Vaccine

hygiene

Question 20

One of the most common infectious diseases of dogs is ____

Answer 20

Canine parvovirus-2

CPV-1 is mild illness and unimportant

Question 21

CPV-2: transmission

Answer 21

Oro-nasal exposure to feces
In-utero infection
fomites

Question 22

CPV-2: pathogenesis

Answer 22

Enteritis, Myocarditis, panleukopenia

Question 23

CPV-2: Diagnosis

Answer 23

CS, immunochromatography, ELISA, PCR, virus isolation

NOT serology because of vaccines or previous exposure

Question 24

CPV-2: Control

Answer 24

Vaccine

Hygiene

Question 25

CPV-2: Enteritis treatment

Answer 25

Oseltamivir (Tamiflu)

Question 26

Porcine parvovirus (PPV) infects the _____ system

Answer 26

Reproductive

Question 27

PPV: transmission

Answer 27

Oro-nasal followed by transplacental | Veneral

Question 28

T or F | If the sow is infected, all of her offspring will be infected at the same time

Answer 28

False | Each fetus has its own placenta, so infection happens are different rates

Question 29

Hallmark sign of PPV

Answer 29

Mummified fetuses | abortions are uncommon

Question 30

PPV is a major cause of ___

Answer 30

SMEDI | Stillbirth, mummification, embryo-death, infertility

Question 31

PPV: diagnosis

Answer 31

staining frozen fetal tissues | PCR, ELISA, HA, HI

Question 32

PPV: immunity

Answer 32

vaccinate all breeding stock | can cause persistent herd infection