Papillomaviridae Flashcards
Papillomaviridae characteristics
Non-enveloped, spherical
single, circular double-stranded DNA
Papillomaviridae (HPV) forms warts that are ___
Benign hyperplastic epithelial outgrowths
T or F
the warts may become malignant
True
Example: cervical carcinoma in women
Replication is linked mainly to ____ epithelium
stratified squamous
Wart growth is caused by blocking ___
p53
Warts are most commonly seen in what species
Bovine
HPV: transmission
contaminated fomites
veneral
Fibropapilloma is caused by types
Bovine HPV types 1, 2, and 5
T or F
Fibropapillomas can be found on the prepuce of bulls
False
Warts are found on the penis
Cutaneous papillomas are caused by type
3
Cutaneous papillomas are flat and lack a ____ core
Fibrous core
Bovine HPV-4 causes warts in GIT, this is aggravated by ingestion of
Bracken fern
results in invasive carcinoma
HPV: diagnosis
visible lesions, viruses in TEM
PCR, DNA hybridization
HPV: treatment
surgical removal, topical agents, bovine INF-Alpha
Canine ____ papillomatosis
Canine Oral papillomatosis
COP is characterized by epithelial hyperplasia and cytoplasmic vacuoles called
Koilocytosis
COP: clinical signs
Hallitosis (bad breath), hemorrhage, hypersalivation
difficulty eating and drinking
ocular wart
COP: treatment
surgical removal
autogenous vaccine, vaccine made from removed wart
Feline papillomatosis is typically found in ___
the ear
equine papillomavirus is called
Equine sarcoids
Most susceptible breeds to sarcoids
Arabians, Appaloosa, american quarter horse
Less susceptible breeds
Standardbred and Thoroughbreds
Sarcoids: clinical signs
common in traumatic areas, single or multiple
large, may ulcerate
appears as “Proud flesh”
Sarcoids: diagnosis
clinical features
histology
viral detection
Sarcoids: treatment
surgical removal
local immune modulation
local radiotherapy
