Circoviridae Flashcards
Circoviridae Characterisitcs
small viruses 17-22 nm circular single-stranded DNA genome -Circovirus- ambisence DNA -Gyrovirus- negative sense DNA Non-enveloped, spherical with icosahedral
Circoviridae replication occurs in ____
the nucleus of an actively dividing cell
requires cellular proteins and other components during S phase
Post-weaning multisystemic wasting syndrome (PMWS): Hosts
Pigs at 4-6 weeks of age or 2-3 weeks post weaning
PMWS: transmission
fecal-oral is most common
virus found in all secretions
vertical transmission
stable and long infectious period
PMWS: Pathogenesis
poorly understood replication
granulomatous inflammation in viscera with botryoid inclusion bodies
Lymphoid depletion and lymphopenia
botryoid bodies
intracytoplasmic inclusion bodies in virus infected macrophages
PMWS: clinical signs
subclinical iinfection is most common. Morbidity rates from 10-30%
lethargy, progressive weight loss, cough, dyspnoea, slow growth
PMWS: diagnosis
Clinical signs, samples
characteristic histopathology
detection of PCV-2 nucleic acids by PCR
PMWS: vaccination
Chimeric vaccine, inactivated vaccines. vaccinate piglets or sows
Porcine Dermatitis and Nephropathy syndrome (PDNS)
sporadic disease of older asso. with PCV2
Necrotizing skin lesions, vasculitis, and fibrinous glomerulonephritis
Gyrovirus
Chicken infectious anemia
Chicken Anemia virus characteristics
highly contagious disease of young chickens (2-4 weeks)
Chicken Anemia virus: Transmission
virus shed in feces and feather dander
Horizontal trans by inhalation or oral exposure
vertical transmission long infectious period
Chicken Anemia virus: pathogenesis replication sites
hemocytoblasts in bone marrow
precursor T cell in thymus cortex
dividing CD4 and CD8 cells in spleen
Chicken Anemia virus: pathogenesis
protein of CAV virus induce apoptosis, immunosuppression and aplastic anemia
Chicken Anemia virus: Clinical signs
anorectic, lethargy, depressed, weightloss.
thrombocytopenia
PCV is low
subcutaneous hemorrhages and skeletal hemorrhages
Chicken Anemia virus: diagnosis
Clinical signs
Examination of blood
necropsy, histopathology
serology, virus isolation, PCR
Chicken Anemia virus: vaccination
Complex and controls other immunosurpressive viruses
