Adenoviridae

Question 1

Adenoviridae characterisitics

Answer 1

Non-enveloped, hexagonal
12 vertex penton capsomers with fiber protrude
non-segmented, linear double-stranded DNA

Question 2

Adenoviridae replication takes place in ___

Answer 2

Nucleus

Intranuclear inclusion bodies contain large number of virions

Question 3

Adenoviridae act by

Answer 3

agglutinate RBC

Question 4

Adenoviridae: pathogenesis

Answer 4

acute respiratory or gastroenteric disease

Immunosuppression

Question 5

Adeno latency is in

Answer 5

Lymphoid tissues

Question 6

Adenovirus can become oncogenic by deactivated ___ and ___

Answer 6

Rb protein

p53 protein

Question 7

Infectious canine hepatitis (ICH) or aka __

Answer 7

Rubarth’s diseas

Question 8

ICH: hosts

Answer 8

Canines

Bears

Question 9

ICH: transmission

Answer 9

virus found in secretions and excretions

shed in urine, 6-9 months post recovery

Question 10

ICH: replication sites

Answer 10

Macrophages, Kupffer cells, hepatocytes, vascular endothelium

Question 11

ICH: major organ targets

Answer 11

Liver, kidney, spleen, lungs

Question 12

ICH: pathogenesis

Answer 12

Edema liver and gallbladder, cirrhosis, kidney lesions
Corneal edema (blue eyes), DIC

Question 13

Corneal edema is most commonly develops during __

Answer 13

chronic cases or clinical recovery

Question 14

Most common lesion in foxes of ICH is

Answer 14

Encephalitis

Question 15

ICH: diagnosis

Answer 15

Leukopenia, proteinuria

virus isolation in urine, FAT, PCR, ELISA, HI

Question 16

ICH: treatment

Answer 16

supportive care
limit secondary bacterial infection
Vaccinate

Question 17

Canine infectious tracheobronchitis (ITB) is also known as

Answer 17

Kennel Cough

caused by Canine adenovirus-2

Question 18

ITB: transmission

Answer 18

highly contagious- aerosol droplets

Stress and poor hygiene

Question 19

ITB: clinical signs

Answer 19

harsh, dry cough followed by etch/gagging. Cough is “honking” sound
nasal discharge, rhinitis
severe pneumonia

Question 20

ITB: diagnosis

Answer 20

clinical signs, PCR, serology, virus isolation

Question 21

ITB: treatment

Answer 21

antitussives and bronchodilators

Vaccine

Question 22

Equine Adenovirus-1 causes severe respiratory disease combined with ___ foals

Answer 22

Severe combined immunodeficiency (SCID) foals

Question 23

in SCID foals there is a mutation in the ___ protein

Answer 23

DNA-dependent protein kinase

Question 24

SCID: clinical signs

Answer 24

Severe bronchiolitis, pneumonia

generalized EAV infections of organs

Question 25

Adeno capsids are ___ to the cell

Answer 25

Toxic