Adenoviridae Flashcards
Adenoviridae characterisitics
Non-enveloped, hexagonal
12 vertex penton capsomers with fiber protrude
non-segmented, linear double-stranded DNA
Adenoviridae replication takes place in ___
Nucleus
Intranuclear inclusion bodies contain large number of virions
Adenoviridae act by
agglutinate RBC
Adenoviridae: pathogenesis
acute respiratory or gastroenteric disease
Immunosuppression
Adeno latency is in
Lymphoid tissues
Adenovirus can become oncogenic by deactivated ___ and ___
Rb protein
p53 protein
Infectious canine hepatitis (ICH) or aka __
Rubarth’s diseas
ICH: hosts
Canines
Bears
ICH: transmission
virus found in secretions and excretions
shed in urine, 6-9 months post recovery
ICH: replication sites
Macrophages, Kupffer cells, hepatocytes, vascular endothelium
ICH: major organ targets
Liver, kidney, spleen, lungs
ICH: pathogenesis
Edema liver and gallbladder, cirrhosis, kidney lesions Corneal edema (blue eyes), DIC
Corneal edema is most commonly develops during __
chronic cases or clinical recovery
Most common lesion in foxes of ICH is
Encephalitis
ICH: diagnosis
Leukopenia, proteinuria
virus isolation in urine, FAT, PCR, ELISA, HI
ICH: treatment
supportive care
limit secondary bacterial infection
Vaccinate
Canine infectious tracheobronchitis (ITB) is also known as
Kennel Cough
caused by Canine adenovirus-2
ITB: transmission
highly contagious- aerosol droplets
Stress and poor hygiene
ITB: clinical signs
harsh, dry cough followed by etch/gagging. Cough is “honking” sound
nasal discharge, rhinitis
severe pneumonia
ITB: diagnosis
clinical signs, PCR, serology, virus isolation
ITB: treatment
antitussives and bronchodilators
Vaccine
Equine Adenovirus-1 causes severe respiratory disease combined with ___ foals
Severe combined immunodeficiency (SCID) foals
in SCID foals there is a mutation in the ___ protein
DNA-dependent protein kinase
SCID: clinical signs
Severe bronchiolitis, pneumonia
generalized EAV infections of organs
Adeno capsids are ___ to the cell
Toxic
