Parvoviridae Flashcards
Describe the genome of Parvoviridae
linear SSDNA
nonenveloped (which is why parvo survives so well in the environment)
What are the 2 subfamilies of Parvoviridae?
- ParvoviriNae*
- Densovirinae (infects insects)*
What are the 5 genuses of Parvovirinae**?
- Parvovirus*
- Erythrovirus*
- Bocavirus*
- Dependovirus*
- Amdovirus*
BAPED
Parvoviruses replicate in the _________
nucleus
T/F:
Parvoviridae infection will show large intranuclear inclusion bodies
TRUE
T/F:
Parvoviruses can replicate in stationary cells
FALSE!
Parvoviruses can only replicate in DIVIDING cells
Genus Parvovirus includes what 3 viruses?
Feline Panleukopenia
Canine Parvovirus
Porcine Parvovirus
Genus Erythrovirus includes what diseases?
Fifth Disease
Slap Cheek Rash
Goose and duck parvoviruses, and sometimes bovine parvovirus 2 are included in what genus of Parvoviridae?
Genus Dependovirus
This genus of virus is unique because it contains a 3rd orf (open reading frame).
They usually infect the GI and Respiratory tracts and are found in humans, dogs, and cattle.
Genus Bocaviruses
Which genus includes human parvovirus B19
which causes a mild rash illness and aplastic anemia in children along with painful joints.
It is NOT zoonotic.
Genus Erythrovirus
(Fifth disease and Slap Cheek Rash)
Viruses of this genus are unable to replicate and do not cause disease.
Genus Dependovirus
because it DEPENDS on a helper virus, usually adenoviridae
Feline parvovirus causes Feline Panleukopenia (FPV)
what are 2 synonyms for it?
Feline distemper
Feline infectious enteritis
Cats can shed FPV in their urine and feces for ___ weeks after recovery
6 weeks!
How can cats contract Feline Panleukopenia (FPV or Feline Parvovirus)?
Oro-nasally
In-utero
Mechanically via flies
What is the hallmark of Feline Parvovirus that causes profound destruction of all white blood cell elements both in circulation or in lymphoid tissues?
Panleukopenia
Feline Panleukopenia (FPV or Feline Parvovirus)
selectively damages replicating cells in the _______ of the intestinal mucosa
crypts
What is the result of damge to intestinal crypt epithelium caused by
Feline Panleukopenia (FPV or Feline Parvovirus)?
Villous Collapse
Enteritis
Diarrhea
What is the result of damage to Lymph Node and Thymus cells
caused by
Feline Panleukopenia (FPV or Feline Parvovirus)?
Germinal center depletion
Apoptosis of lymphocytes
Thymic atrophy
Lymphopenia