Parvoviridae Flashcards

1
Q

Describe the genome of Parvoviridae

A

linear SSDNA

nonenveloped (which is why parvo survives so well in the environment)

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2
Q

What are the 2 subfamilies of Parvoviridae?

A
  • ParvoviriNae*
  • Densovirinae (infects insects)*
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3
Q

What are the 5 genuses of Parvovirinae**?

A
  • Parvovirus*
  • Erythrovirus*
  • Bocavirus*
  • Dependovirus*
  • Amdovirus*

BAPED

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4
Q

Parvoviruses replicate in the _________

A

nucleus

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5
Q

T/F:

Parvoviridae infection will show large intranuclear inclusion bodies

A

TRUE

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6
Q

T/F:

Parvoviruses can replicate in stationary cells

A

FALSE!

Parvoviruses can only replicate in DIVIDING cells

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7
Q

Genus Parvovirus includes what 3 viruses?

A

Feline Panleukopenia

Canine Parvovirus

Porcine Parvovirus

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8
Q

Genus Erythrovirus includes what diseases?

A

Fifth Disease

Slap Cheek Rash

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9
Q

Goose and duck parvoviruses, and sometimes bovine parvovirus 2 are included in what genus of Parvoviridae?

A

Genus Dependovirus

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10
Q

This genus of virus is unique because it contains a 3rd orf (open reading frame).

They usually infect the GI and Respiratory tracts and are found in humans, dogs, and cattle.

A

Genus Bocaviruses

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11
Q

Which genus includes human parvovirus B19

which causes a mild rash illness and aplastic anemia in children along with painful joints.

It is NOT zoonotic.

A

Genus Erythrovirus

(Fifth disease and Slap Cheek Rash)

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12
Q

Viruses of this genus are unable to replicate and do not cause disease.

A

Genus Dependovirus

because it DEPENDS on a helper virus, usually adenoviridae

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13
Q

Feline parvovirus causes Feline Panleukopenia (FPV)

what are 2 synonyms for it?

A

Feline distemper

Feline infectious enteritis

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14
Q

Cats can shed FPV in their urine and feces for ___ weeks after recovery

A

6 weeks!

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15
Q

How can cats contract Feline Panleukopenia (FPV or Feline Parvovirus)?

A

Oro-nasally

In-utero

Mechanically via flies

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16
Q

What is the hallmark of Feline Parvovirus that causes profound destruction of all white blood cell elements both in circulation or in lymphoid tissues?

A

Panleukopenia

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17
Q

Feline Panleukopenia (FPV or Feline Parvovirus)

selectively damages replicating cells in the _______ of the intestinal mucosa

A

crypts

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18
Q

What is the result of damge to intestinal crypt epithelium caused by

Feline Panleukopenia (FPV or Feline Parvovirus)?

A

Villous Collapse

Enteritis

Diarrhea

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19
Q

What is the result of damage to Lymph Node and Thymus cells

caused by

Feline Panleukopenia (FPV or Feline Parvovirus)?

A

Germinal center depletion

Apoptosis of lymphocytes

Thymic atrophy

Lymphopenia

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20
Q

What is the result of damage to bone marrow caused by

Feline Panleukopenia (FPV or Feline Parvovirus)?

A

stem cell depletion

Neutropenia–>Thrombocytopenia–>Anemia

21
Q

What is the result of damage to a fetus caused by

Feline Panleukopenia (FPV or Feline Parvovirus)?

A

Loss of pregnancy

22
Q

T/F:

Feline Panleukopenia (FPV or Feline Parvovirus)

can affect the cerebellum of cats.

A

TRUE!!

It can cause cerebellar hypoplasia and eventually cerebellar ataxia

23
Q

In-utero *Feline Panleukopenia (FPV or Feline Parvovirus) *infection can cause

this in kittens whose mother was infected during early fetal development

A

Optic Nerve hypoplasia

24
Q

When does a mother cat have to be infected with Feline Panleukopenia (FPV or Feline Parvovirus)

in order for cerebellar hypoplasia to occur?

A

During the last 2 weeks of pregnancy

25
Q

In addition to cerebellar hypoplasia, what other CNS disease can a cat infected with

Feline Panleukopenia (FPV or Feline Parvovirus)

have?

A

Hydraencephaly

26
Q

Kittens with Feline Panleukopenia (FPV or Feline Parvovirus)

are also susceptible to _________

A

secondary bacterial infections

27
Q

T/F:

Disseminated Intravascular Coagulation DIC is a characteristic of

Feline Panleukopenia (FPV or Feline Parvovirus)

A

TRUE

28
Q

T/F:

A modified-live virus is safe and effective for all cats infected with

Feline Panleukopenia (FPV or Feline Parvovirus)

A

FALSE!

YOU SHOULD NEVER GIVE AN MLV TO:

Pregnant, immunosuppressed, sick cats or kittens less than 4 weeks old

29
Q

The first vaccination for kittens against Feline Panleukopenia (FPV or Feline Parvovirus)

is at 6 - 9 weeks old.

The last dose of the initial vaccine should be given after the kitten is

_______ weeks old, as to not mess with the maternal antibodies

A

16 weeks old

30
Q

T/F:

Canine Parvovirus 1 is the severe form of *Parvovirus *in dogs and very deadly

A

FALSE!!!

*Canine Parvovirus 2 *is the deadly one

31
Q

What are the 3 antigenic variants of

Canine Parvovirus 2?

A

CPV 2a

CPV 2b

CPV 2c

2b and 2c are found in America!

32
Q

Clinically, 3 age related syndromes have been recognized as associated with

Canine Parvovirus 2

Days 2-12 causes ____________ and is uncommon

A

generalized neonatal disease

33
Q

Clinically, 3 age related syndromes have been recognized as associated with

Canine Parvovirus 2

Age 3 - 8 weeks causes __________

A

Myocarditis

34
Q

Clinically, 3 age related syndromes have been recognized as associated with

Canine Parvovirus 2

**Ages 2 - 4 months **causes _________ and ________ and is the most common

A

enteritis and panleukopenia

35
Q

T/F:

Serology is a good method for testing for

Canine Parvovirus 2

A

FALSE!!!

Serology sucks for Canine Parvovirus 2

Use a SNAP test for parvo instead!

36
Q

When should the first round of shots be given to prevent puppies from getting

Canine Parvovirus 2?

A

7 weeks

11 weeks

15 weeks

Booster after 1 year

Every 3 years after the booster

37
Q

T/F:

Oseltamivir has been shown to reduce symptoms of Parvovirus

Feline Panleukopenia Virus (**FPV) and Canine Parvovirus 2

A

TRUE!

38
Q

What is an infectious cause of reproductive failure causing SMEDI in swine throughout the world?

A

Porcine Parvovirus

39
Q

T/F:

Death at different stages of pregnancy is typical of Porcine Parvovirus

A

TRUE

40
Q

What is the HALLMARK of Porcine Parvovirus?

A

The increase in mummified fetuses after a normal gestation period

41
Q

T/F:

Abortions are a common symptoms of pigs infected with Porcine Parvovirus

A

FALSE!!

ABORTIONS are NOT common

42
Q

In Porcine Parvovirus, time of infection is CRITICAL.

What happens if a sow is infected in the

first 30 days of gestation?

A

The fetus dies and is reabsorbed

43
Q

In Porcine Parvovirus, time of infection is CRITICAL.

What happens if a sow is infected between

**30 - 70 days **into gestation?

A

Fetuses die and become mummified

44
Q

In Porcine Parvovirus, time of infection is CRITICAL.

What happens if a sow is infected

After 70 days of gestation?

A

late fetuses develop lesions but also mount immune response and survive in-utero

45
Q

T/F:

Although uncommon, pigs infected with Porcine Parvovirus can suffer from

respiratory tract diseases and vesicular diseases

A

TRUE!

46
Q

T/F:

Serological tests are useful in diagnosing Porcine Parvovirus

A

FALSE

Serology is USELESS in diagnosis of Porcine Parvovirus

47
Q

Unlike most parvoviruses, Porcine parvovirus

can cause _______ infections with ________ shedding

A

Porcine parvovirus

can cause persistent infections with periodical sheddiing

48
Q

What is the best way to prevent Porcine Parvovirus?

A

Vaccinate all susceptible breeding stock twice, 2 weeks apart, several weeks before breeding