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VIROLOGY Practice Questions > Papillomaviridae > Flashcards

Papillomaviridae Flashcards

1
Q

Describe the genome of Papillomaviridae

A

Circular DSDNA

nonenveloped, can be oncogenic

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2
Q

Papillomaviuses produce _______ on the skin and mucuous membranes of most animal species

A

WARTS

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3
Q

Benign neoplasms that hyperplastic epithelial growths that generally regress spontaneously

A

WARTS

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4
Q

T/F:

Benign warts may progress to malignancy

A

True

Example: HPV can cause cervical carcinoma in women

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5
Q

Papillomaviruses infect __________ in the ________ layer of the epithelium

A

Papillomaviruses infect keratinocytes in the basal layer of the epithelium

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6
Q

Virus accumulation is most noticeable in the _________ __________ layer of epithelium

A

stratum granulosum

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7
Q

Virions of Papillomaviruses are typically shed from the ________-most layers of epithelium

A

upper-most

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8
Q

In *Papillomaviruses *

benign warts have ___________ (unintegrated) DNA

A

EPISOMAL

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9
Q

In Papillomaviruses

malignant cancers have DNA that is _________ into the host DNA,

A

INTEGRATED

This means integration is necessary for malignant transformation

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10
Q

In Papillomaviruses

integration disrupts one of the early genes, _______, which is a viral repressor

A

E2

is a viral repressor

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11
Q

Which 2 viral oncogenes in Papillomaviruses

remain intact and cause the malignant transformation

A

The viral oncogenes are

E6 and E7

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12
Q

What is the job of viral oncogene E6 in Papillomaviruses?

A

**E6 **prevents p53 from doing apoptosis on damaged cells

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13
Q

What is the job of viral oncogene **E7 **in Papillomaviruses?

A

E7 binds to Rb and prevents it from stopping damaged cell proliferation

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14
Q

Bovine Papillomaviruses can affect these 2 species

A

Cows and Horses too!

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15
Q

Intestinal papillomas are caused by Type _____ Bovine Papillomavirus

A

Type 4

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16
Q

Sarcoids in horses are caused by which 2 Papillomaviruses?

A

Bovine papillomavirus 1 and 2

cause sarcoids in horses

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17
Q

Which species of animal is known to get oral papilloma Type 1?

A

DOGS!

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18
Q

Type _____ Canine Papillomavirus causes endophytic papillomas

A

Type 2

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19
Q

Warts are more commonly seen in _________ than in any other domestic species

A

bovines

20
Q

Benign warts that present as large, cauliflower-like growths with a

fibrous core covered with stratified squamous epithelium

with the outer layers keratinized

A

Fibropapillomas

21
Q

Which types of Bovine Papillomaviruses cause

fibropapillomas?

A

Bovine Papillomaviruses

**1, 2, **and 5

cause

fibropapillomas (cauliflower growths)

22
Q

Fibropapillomas are found frequently on the penis

but NOT on the prepuce in this species

A

Young Bulls

get fibropapillomas on their penises, but NOT their prepuces

23
Q

*Bovine Papillomavirus *Type 3 causes _______ papillomas

A

cutaneous

24
Q

What is the difference between a fibropapilloma and a cutaneous papilloma?

A

Cutaneous papillomas lack a fibrous core

and fibropapillomas are caused by Bovine Types 1, 2, and 5

while cutaneous papillomas are caused by Bovine Type 3 only

25
Q

Bracken Fern is associated with Bovine Papillomavirus Type ______

A

Bracken Fern is associated with Type 4

26
Q

Type 4 Bovine Papillomavirus can cause invasive carcinoma of the

__________ tract

A

alimentary** tract cancer**

caused by Type 4

which is associated with Bracken Fern ingestion

27
Q

This plant contains carcinogens, mutagens, and immunosuppressive chemicals

that can cause cancer in cows that eat it

A

BRACKEN FERN

BEWAREEEEEEE

28
Q

In cattle that eat bracken fern, Bovine Papillomavirus Types ____ & ____

may contribute to the syndrome of enzootic hematuria

that is characterized by bloody urine and/or urinary bladder cancer

A

In cattle that eat bracken fern, Bovine Papillomavirus Types 1 & 2

may contribute to the syndrome of enzootic hematuria

that is characterized by bloody urine and/or urinary bladder cancer

29
Q

Which 3 types of Bovine Papillomaviruses are associated in any way with bracken fern?

A

Type **4 **(cause transient papillomas in the alimentary tract)

Types 1 & 2 (contribute to enzootic hematuria)

30
Q

What 3 agents can be used to treat Bovine Papillomaviruses?

A

**Podophyllin **and DMSO topical agents

or

Bovine Interferon-a

31
Q

In Canine Oral Papillomatosis,

Warts usually begin on the _____ and can spread to the

*buccal mucosa, tongue, palate, *and pharynx

A

lips

32
Q

Canine Oral Papillomatosis

is characterized histologically

in what 2 ways?

A

Canine Oral Papillomatosis

is characterized by

epithelial hyperplasia

and

cytoplasmic vacuolization (koilocytosis)

33
Q

What is koilocytosis?

A

Koilocytosis is the **cytoplasmic vacuolization **seen histologically in dogs infected with Canine Oral Papillomatosis

34
Q

T/F:

Canine Oral Papillomatosis can progress to squamous cell carcinoma

A

TRUE

it is rare but it can happen

35
Q

In dogs, clinical signs of _______________

include **halitosis, ptyalisms (hypersalivation), **and hemorrhage

A

Canine Oral Papillomatosis

36
Q

T/F:

*Canine Oral Papillomatosis *can cause ocular warts

A

TRUE!

  • Canine Oral Papillomatosis* can cause **ocular warts **on the
  • conjunctiva, cornea, and eyelid margins*
37
Q

Dogs that have recovered from Canine Oral Papillomatosis

are ________ to reinfection

A

refractory

38
Q

T/F:

Secondary bacterial infection occurs with Canine Oral Papillomatosis

A

TRUE

39
Q

T/F:

Autogenous Vaccine are effective in treating Canine Oral Papillomatosis

A

FALSE

efficacy is doubtful at best

40
Q

The most common neoplasm in horses is

A

SARCOIDS

41
Q

Locally invasive benign fibroblastic skin tumors that do not metastasize

A

SARCOIDS

42
Q

Sarcoids are associated with *Bovine Papillomavirus *Types ___ & ___

A

**1 **and 2

43
Q

Breeds of horses that are susceptible to sarcoids include

A

Arabians

Appaloosas

American Quarter Horses

AAA are susceptible!

44
Q

These 2 breeds of horses are not susceptible to sarcoids

A

Standardbreds

Thoroughbreds

Thoroughbreds & Standardbreds

are

NOT SUSCEPTIBLE

45
Q

Sarcoid lesions usually occur in previously __________ areas

A

traumatized

46
Q

T/F:

Horses can develop ocular and palpebral sarcoids

A

TRUE

47
Q

Sarcoids look just like proud flesh except for that sarcoids….

A

are seen at sites of previous injury!

VIROLOGY Practice Questions (11 decks)

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