part 7 Flashcards
1
Q
What has the same MOA as penicillin?
A
cephalosporins
2
Q
What is cephalosporin resistance due to?
A
-production of beta lactamases (enzymes that cleave the ring and inactivate the drug
3
Q
Why are their 5 generations of cephalosporins?
A
due to resistance
4
Q
How is toxicity for cephalosporins?
A
low
5
Q
What are the adverse effects of cephalosporins?
A
- allergic reaction
- bleeding
- thrombophelbitis (edema and clot)
- hemolytic anemia (RBC destruction)
6
Q
What are the drug interactions of cephalosporins?
A
- alcohol (causes vomiting)
- drugs that promote bleeding
- calcium and ceftriaxone
7
Q
What are 2 types of cephalosporins?
A
- cephalexin (keflex)
- ceftriaxone (rocephin)
8
Q
Is C.diff gram positive or negative?
A
gram positive
9
Q
What are the causes of C.diff?
A
- antibiotics: clindamycin, 2nd and 3rd gen cephalosporins, and fluoroquinolones
- health care (workers and setting)
10
Q
How is C.diff treated?
A
- Metronidazole (flagyl) if allergic treat with….
- Vancomycin
11
Q
What is the most important thing to check before administering the antibiotic penicillin.
A
allergies
