part 10

Question 1

These like tetracyclines are bacteriostatic inhibitors of protein synthesis?

Answer 1

macrolides

Erythromycin

Question 2

What spectrum are macrolides?

Answer 2

broad spectrum

Question 3

What is used an an alternative to PCN (penicillin)?

Answer 3

macrolides

Question 4

Where are macrolides eliminated?

Answer 4

through the liver

Question 5

What are the adverse effects of macrolides?

Answer 5

• GI (N,V,D, epigastric pain)

- QT prolongation causing potential ventricular dysrhythmia and sudden cardiac death

Question 6

What do you need to avoid if taking macrolides?

Answer 6

• calcium channel blockers
• azole anti fungal drugs
• HIV protease inhibitors

Question 7

What can clindamycin promote?

Answer 7

CDAD: Clostridium difficile-Associated Diarrhea

Question 8

What are the s/s of CDAD caused by clindamycin?

Answer 8

• profuse, watery diarrhea (10-20 stools per day)
• mucus or blood in stools
• abdominal pain, fever
• may develop 4 to 6 weeks after medication withdrawal.
• can be fatal

Question 9

If a patient gets C.diff fro clindamycin the pt should discontinue and what needs to be given?

Answer 9

• vanco

- flagyl

Question 10

This is the first in class for oxazolidinone.

Answer 10

Linezolid

Question 11

What are 2 important things Linezolid can treat?

Answer 11

• VRE: vanco-resistant enterococci

- MRSA: methicillin-resistant staph aureus

Question 12

What lab need to be drawn weekly for a pt on Linezolid and why?

Answer 12

• CBC

- because it can cause reversible myelosuppression - anemia, leukopenia, thrombocytopenia, and/or pancytopenia

Question 13

What happens if Linezolid is combined with an SSRI?

Answer 13

-can cause death = serotonin syndrome