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Dosage Forms > PART 6 > Flashcards

PART 6 Flashcards

1
Q

Dosage forms having drug-release features based on time, course, and/or location that are designed to accomplish therapeutic or convenience objectives not offered by conventional or immediate-release forms

A

Modified release dosage form

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2
Q

Allows a reduction in dosing frequency from that necessitated by a conventional dosage form, such as a solution or an immediate-release dosage form

A

Extended release (ER)

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3
Q

Initial dose of the drug is released immediately while the second dose follows later

A

Repeat-action tablets

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4
Q

Drugs with low dosage and fairly rapid rates of absorption and excretion are the best candidates for ___ tablets.

A

Repeat-action tablets

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5
Q

Designed to release the drug at a time other than promptly
after administration

A

Delayed-release dosage form

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6
Q

Coated tablets and capsules that remain intact in the stomach to release their contents in the intestine are called ____.

A

Enteric coated

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7
Q

Enteric coating that breaks down in the less acidic environment of the intestine

A

pH dependent

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8
Q

Enteric coating that erodes by moisture over time during GI transit

A

Time dependent

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9
Q

Enteric coating that deteriorates as a result of hydrolysis-catalyzing action of intestinal enzymes

A

Enzyme dependent

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10
Q

Material for enteric coating

A

Fats
Fatty acids
Waxes
Shellac
Cellulose acetate phthalate

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11
Q

Describes a drug release directed toward isolating or concentrating a drug in a body region, tissue, or site for absorption or for drug action

A

Targeted release

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12
Q

TECHNOLOGIES USED IN EXTENDED-RELEASE DOSAGE FORMS

Beads, granules, and microspheres are coated in various thicknesses by ___, ___, and ___.

A

Lipid material
Cellulosic material
Commercial aqueous coating systems

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13
Q

TECHNOLOGIES USED IN EXTENDED-RELEASE DOSAGE FORMS

Ethylcellulose

A

Cellulosic material

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14
Q

TECHNOLOGIES USED IN EXTENDED-RELEASE DOSAGE FORMS

Ethylcellulose with plasticizer (Aquacoat by FMC Corporation or Surelease by Colorcon)

A

Commercial aqueous coating systems

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15
Q

TECHNOLOGIES USED IN EXTENDED-RELEASE DOSAGE FORMS

Solids, liquids, or even gases may be encapsulated into microscopic size particles through the formation of thin coatings of “wall” materials around the substance being encapsulated.

A

Microencapsulation

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16
Q

TECHNOLOGIES USED IN EXTENDED-RELEASE DOSAGE FORMS

4 Wall-forming materials used in microencapsulation

A

Gelatin - common
Polyvinyl alcohol
Ethylcellulose
Polyvinyl chloride

17
Q

TECHNOLOGIES USED IN EXTENDED-RELEASE DOSAGE FORMS

Embedding a drug in an inert plastic matrix such as polyethylene, polyvinyl acetate, or polymethacrylate then compressing it into a tablet.

A

Matrix tablets

18
Q

TECHNOLOGIES USED IN EXTENDED-RELEASE DOSAGE FORMS

The API in matrix tablets is slowly released by ___ from the plastic matrix by leaching into the body fluids.

A

Diffusion

19
Q

TECHNOLOGIES USED IN EXTENDED-RELEASE DOSAGE FORMS

Drug substances are combined with other chemical agents to form complexes that may be only slowly soluble in body fluids

A

Complex formation

20
Q

TECHNOLOGIES USED IN EXTENDED-RELEASE DOSAGE FORMS

The release of the drug is dependent upon the pH and the electrolyte concentration in the GIT

A

Ion-exchange resins

21
Q

TECHNOLOGIES USED IN EXTENDED-RELEASE DOSAGE FORMS

Pioneer oral osmotic pump delivery system that is composed of a core tablet surrounded by a semi-permeable membrane coating having a 0.4-mm diameter “hole” produced by a laser beam

A

OROS System (by Alza)

22
Q

TECHNOLOGIES USED IN EXTENDED-RELEASE DOSAGE FORMS

The core tablet of OROS system consists of the active layer that contains the drug and the ___ layer that contains the polymeric osmotic agent.

A

Push

23
Q

TECHNOLOGIES USED IN EXTENDED-RELEASE DOSAGE FORMS

The drug is released 4 to 5 hours after tablet ingestion. The delay in drug release is affected by a slowly solubilized coated layer between the active drug core and the outer semipermeable membrane.

A

COER (Controller-Onset Extended Release)

24
Q

TECHNOLOGIES USED IN EXTENDED-RELEASE DOSAGE FORMS

A type of push-pull osmotic system

A

GITS (Gastrointestinal Therapeutic System)

Dosage Forms (6 decks)

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