PART 4 Flashcards by Karrizze Basto

Q

“Capsula” means ___.

A

small container

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Q

Solid dosage forms in which the medicinal agents and/or inert substances are enclosed in a small gelatin shell.

A

Capsules

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Q

Gelatin is a product of partial ____ of collagen obtained from the skin, white connective tissue, and bones of animals.

A

Hydrolysis

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Q

Type A Gelatin is derived from ___ by acid processing.

A

Pork skin

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Q

Type B Gelatin is obtained from ___ by alkaline processing.

A

Bones and animal skins

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Q

Type of capsule used by community pharmacists in extemporaneous compounding of prescriptions. It is also commonly employed in clinical drug trials to compare investigational drug to another drug or a placebo.

A

Hard gelatin capsules

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Q

Hard gelatin capsules are also called ___ or ___.

A

Dry-filled capsule or 2-piece capsule

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Q

Gelatin contain ___ to ___ of moisture

A

13% to 16%

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Q

Capsule shell sizes for hard gelatin capsules

A

000 (largest)
00
1
2
3
4
5 (smallest)

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Q

Opaquant used in hard gelatin capsules

A

Titanium dioxide

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Q

Component of hard gelatin capsules that prevents decomposition

A

0.15% Sulfur dioxide

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Q

IDENTIFY THE COMPONENT OF HARD GELATIN CAPSULE DESCRIBED.

It is used to produce the proper capsule fill volume and improve content uniformity.

A

Diluents/Fillers

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Q

IDENTIFY THE COMPONENT OF HARD GELATIN CAPSULE DESCRIBED.

Assist break-up and distribution of the capsule contents in the stomach.

A

Disintegrants

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Q

IDENTIFY THE COMPONENT OF HARD GELATIN CAPSULE DESCRIBED.

Improve flow properties of powder mixture

A

Lubricants or glidants

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Q

IDENTIFY THE COMPONENT OF HARD GELATIN CAPSULE DESCRIBED.

Facilitates wetting of powder by the GI fluids

A

Surface active agents

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Q

IDENTIFY THE COMPONENT OF HARD GELATIN CAPSULE DESCRIBED.

Sodium lauryl sulfate

A

Surface active agents

Q

IDENTIFY THE COMPONENT OF HARD GELATIN CAPSULE DESCRIBED.

Fumed silicon dioxide
Magnesium stearate (!!!)
Calcium stearate
Stearic acid
Talc

A

Lubricants or glidants

Q

IDENTIFY THE COMPONENT OF HARD GELATIN CAPSULE DESCRIBED.

Pregelatinized starch
Croscarmellose
Sodium starch glycolate

A

Disintegrants

Q

IDENTIFY THE COMPONENT OF HARD GELATIN CAPSULE DESCRIBED.

Lactose
Microcrystalline cellulose
Starch

A

Diluents or Fillers

Q

Capsule filling method used in small scale production.

A

Punch method

Q

The process by which the inner surface of the cap is lightly coated with a warm gelatin solution. For large-scale, heat welding or liquid welding is employed.

A

Capsule sealing

Q

What is the moisture content of soft gelatin capsule?

A

6-10%

Q

It is used to render soft gelatin capsules elastic or plastic-like.

A

Plasticizer (Glycerin or polyhydric alcohol such as sorbitol)

Q

API: Plasticizer ratio

A

1:0.08

Preservatives added to prevent fungal growth in soft gelatin capsules

Methylparaben or propylparaben

METHODS OF PREPARING SGC It is a continuous process wherein two plasticized gelatin ribbons are continuously and simultaneously fed with liquid or paste fill between the rollers of the rotary die mechanism.

Rotary Die Process

Gelatin ribbons are fed between a set of vertical dies that continually open and close to form rows of packets in gelatin ribbons.

Reciprocating Die Process

METHODS OF PREPARING SGC A warm sheet of plain or colored gelatin is placed on the bottom plate of the mold, and the medication-containing liquid is evenly poured on it.

Plate Process

Three examples of desiccants used for capsules

Silica gel Clay Activated charcoal

Hermetically sealed capsules that encapsulate liquids, suspensions, pasty materials, or dry powders

Soft gelatin capsules