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Dosage Forms > PART 5 > Flashcards

PART 5 Flashcards

1
Q

It contains drug substances usually prepared with the aid of suitable excipients

A

Tablets

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2
Q

METHODS OF PREPARATION FOR TABLETS

___ tablets are prepared using the molding method.

A

Soft

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3
Q

METHODS OF PREPARATION FOR TABLETS

___ tablets are made by compression method.

A

Hard

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4
Q

METHODS OF PREPARATION FOR TABLETS

Forcing dampened powder material into a mold from which the formed tablet is then ejected and allowed to dry.

A

Molding method

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5
Q

METHODS OF PREPARATION FOR TABLETS

Manufactured with tablet machines capable of exerting great pressure in compacting the powdered or granulated material. Their shape and dimensions are determined by the use of various shaped punches and dies.

A

Compression method (Wet granulation method, dry granulation method, or by direct compression)

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6
Q

TABLET EXCIPIENTS

Designed to make up the desired bulk, flow properties, and compression characteristics

A

Diluents or fillers

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7
Q

TABLET EXCIPIENTS

Used to cause adhesion of powder particles in tablet granulations

A

Binders

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8
Q

TABLET EXCIPIENTS

Promote disruption of solid mass into smaller particles

A

Disintegrants

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9
Q

TABLET EXCIPIENTS

Enhance flow properties of powders

A

Glidants

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10
Q

TABLET EXCIPIENTS

Reduce friction during tablet compression

A

Lubricants

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11
Q

TABLET EXCIPIENTS

Prevent tablet ingredients from sticking to punches and dies during production

A

Anti-adherent

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12
Q

TABLET EXCIPIENTS

Usually limited to chewable and buccal tablets

A

Flavoring or Sweetening Agents

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13
Q

TABLET EXCIPIENTS

Lactose
Mannitol
Starch
Dibasic Calcium Phosphate
Sorbitol
Powdered Cellulose

A

Diluents or fillers

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14
Q

TABLET EXCIPIENTS

Acacia
Alginic acid
Carboxymethyl cellulose (CMC)
Gelatin
Methylcellulose (MC)
Ethylcellulose (EthC)
Compressible sugar (Nu-tab)
Liquid glucose
Povidone
Pregelatinized starch

A

Binders

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15
Q

TABLET EXCIPIENTS

CMC
CMC Calcium
Microcrystalline cellulose
Starches

A

Disintegrants

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16
Q

TABLET EXCIPIENTS

Colloidal silica
Cornstarch
Talc

A

Glidants

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17
Q

TABLET EXCIPIENTS

Ca/Mg/Zn stearate
Mineral oil
Stearic acid

A

Lubricants

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18
Q

TABLET EXCIPIENTS

Magnesium stearate

A

Anti-adherent

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19
Q

TABLET EXCIPIENTS

Dibasic calcium phosphate (ditab)

A

Direct Compression Excipients

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20
Q

TABLET EXCIPIENTS

FD&C lakes

A

Colors and Dyes

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21
Q

TABLET EXCIPIENTS

MC
EthC
Hydroxy-ethyl/propyl cellulose

A

Film-coating

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22
Q

TABLET EXCIPIENTS

Cellulose acetate phthalate
Shellac (35% in alcohol, “pharmaceutical glaze”)

A

Enteric-coating

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23
Q

TABLET EXCIPIENTS

Liquid glucose
Sucrose

A

Sugar-coating

24
Q

TABLETS FOR ORAL INGESTION

Uncoated tablet manufactured by compression, with sufficient pressure forcing the powders or granules to make the desired shape

A

Compressed tablet

25
Q

TABLETS FOR ORAL INGESTION

Designed to disintegrate and release their medication with no specific rate-controlling features

A

Immediate release tablet

26
Q

TABLETS FOR ORAL INGESTION

Designed to release their medication in a predetermined
manner over an extended period

A

Extended-release tablet (controlled-release tablet)

27
Q

TABLETS FOR ORAL INGESTION

Coated with a thin layer of polymer capable of forming a skin-like film over the tablet

A

Film-coated tablets

28
Q

TABLETS FOR ORAL INGESTION

Each layer contains a different medicinal agent, separated
either due to physical or chemical incompatibility or staged drug release or the manufacturer wants to have a unique appearance of the layered tablets

A

Multiple-compressed tablets (multi-layered or tablet within a tablet)

29
Q

TABLETS FOR ORAL INGESTION

50% larger and heavier than the original uncoated tablet and time-consuming since it requires 5-6 stages.

A

Sugar-coated tablet

30
Q

TABLETS FOR ORAL INGESTION

Facilitates swallowing and is more tamper-evident than unsealed capsules

A

Gelatin-coated tablets (GELCAPS)

31
Q

TABLETS FOR ORAL INGESTION

Tablet is intact in the stomach but disintegrates in the small intestine

A

Enteric-coated Tablets

32
Q

TABLETS USED IN ORAL CAVITY

These drugs are destroyed by ___ and poorly absorbed in GIT.

A

gastric juices

33
Q

TABLETS USED IN ORAL CAVITY

These tablets are to be dissolved in the buccal pouch (cheek). They are designated to erode slowly (4hrs disintegration time).

A

Buccal tablets

34
Q

TABLETS USED IN ORAL CAVITY

Dissolved under the tongue and absorbed into your blood
through the tissue. Dissolve promptly and provide rapid drug effect.

A

Sublingual tablets

35
Q

TABLETS USED IN ORAL CAVITY

They are intended to be dissolved slowly in the oral cavity for localized effects.

A

Lozenges or Troches

36
Q

TABLETS USED IN ORAL CAVITY

Gummy type of lozenges/troches

A

Pastilles

37
Q

TABLETS USED IN ORAL CAVITY

Liquefies or dissolves in the mouth within 1 minute, some within 10 seconds for children and elderly who has difficulty swallowing.

A

Rapidly Dissolving Tablets

38
Q

TABLETS USED IN ORAL CAVITY

Disc-shaped, solid dosage forms containing the medicinal agent and generally a flavoring substance in a hard candy or sugar base.

A

Lozenges or Troches

39
Q

TABLETS USED IN ORAL CAVITY

Disintegrate smoothly and rapidly when chewed or allowed to dissolve in the mouth. Do not contain disintegrants.

A

Chewable tablets

40
Q

TABLETS USED IN ORAL CAVITY

What is used for sugar-free chewable tablets?

A

Xylitol

41
Q

TABLETS USED IN ORAL CAVITY

What is the commonly used excipient in chewable tablets?

A

Mannitol

42
Q

TABLETS USED TO PREPARE SOLUTION

Prepared by compressing granular effervescent salt and releases carbon dioxide when in contact with water

A

Effervescent tablets

43
Q

TABLETS USED TO PREPARE SOLUTION

Prepared by mixing the active drug with lactose, dextrose, sucrose, mannitol, or some other appropriate diluent that can serve as the base

A

Tablet triturates (Molded tablets)

44
Q

TABLETS USED TO PREPARE SOLUTION

Small, usually cylindrical molded or compressed tablet containing small amount of usually potent drugs

A

Tablet triturates (Molded tablets)

45
Q

TABLETS USED TO PREPARE SOLUTION

What is the preferred base for tablet triturates (molded tablets)?

A

Lactose

46
Q

TABLETS USED TO PREPARE SOLUTION

This adds a pleasant, cooling sensation and additional sweetness in the mouth in tablet triturates (molded tablets).

A

Mannitol

47
Q

OTHER SOLID DOSAGE FORMS FOR ORAL ADMINISTRATION

Small, round, solid dosage forms containing a medicinal agent intended to be administered orally

A

Pills

48
Q

PILL CLASSIFICATION ACCORDING TO WEIGHT

Pravules (Small) - potent

A

20 mg

49
Q

PILL CLASSIFICATION ACCORDING TO WEIGHT

Granules

A

20 to 60 mg

50
Q

PILL CLASSIFICATION ACCORDING TO WEIGHT

Pills

A

60 to 500 mg

51
Q

PILL CLASSIFICATION ACCORDING TO WEIGHT

Boluses (big pills) for veterinary use

A

700 to 2000 mg

52
Q

OTHER SOLID DOSAGE FORMS FOR ORAL ADMINISTRATION

Raspberry sugar-based lozenge on a stick containing fentanyl citrate

A

Lollipop (BN: Actiq)

53
Q

OTHER SOLID DOSAGE FORMS FOR ORAL ADMINISTRATION

The first product designed to aid in controlling breakthrough pain in cancer patients that provides immediate relief that lasts for 15 minutes

A

Actiq

54
Q

OTHER SOLID DOSAGE FORMS FOR ORAL ADMINISTRATION

Small, solid particles of uniform shape sometimes called “beads” that can be administered orally or parenterally

A

Pellets

55
Q

OTHER SOLID DOSAGE FORMS FOR ORAL ADMINISTRATION

Used to provide physical separation for chemically or physically incompatible materials, extended release of an API

A

Pellets

Dosage Forms (6 decks)

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