PART 5 Flashcards

1
Q

It contains drug substances usually prepared with the aid of suitable excipients

A

Tablets

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2
Q

METHODS OF PREPARATION FOR TABLETS

___ tablets are prepared using the molding method.

A

Soft

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3
Q

METHODS OF PREPARATION FOR TABLETS

___ tablets are made by compression method.

A

Hard

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4
Q

METHODS OF PREPARATION FOR TABLETS

Forcing dampened powder material into a mold from which the formed tablet is then ejected and allowed to dry.

A

Molding method

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5
Q

METHODS OF PREPARATION FOR TABLETS

Manufactured with tablet machines capable of exerting great pressure in compacting the powdered or granulated material. Their shape and dimensions are determined by the use of various shaped punches and dies.

A

Compression method (Wet granulation method, dry granulation method, or by direct compression)

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6
Q

TABLET EXCIPIENTS

Designed to make up the desired bulk, flow properties, and compression characteristics

A

Diluents or fillers

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7
Q

TABLET EXCIPIENTS

Used to cause adhesion of powder particles in tablet granulations

A

Binders

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8
Q

TABLET EXCIPIENTS

Promote disruption of solid mass into smaller particles

A

Disintegrants

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9
Q

TABLET EXCIPIENTS

Enhance flow properties of powders

A

Glidants

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10
Q

TABLET EXCIPIENTS

Reduce friction during tablet compression

A

Lubricants

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11
Q

TABLET EXCIPIENTS

Prevent tablet ingredients from sticking to punches and dies during production

A

Anti-adherent

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12
Q

TABLET EXCIPIENTS

Usually limited to chewable and buccal tablets

A

Flavoring or Sweetening Agents

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13
Q

TABLET EXCIPIENTS

Lactose
Mannitol
Starch
Dibasic Calcium Phosphate
Sorbitol
Powdered Cellulose

A

Diluents or fillers

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14
Q

TABLET EXCIPIENTS

Acacia
Alginic acid
Carboxymethyl cellulose (CMC)
Gelatin
Methylcellulose (MC)
Ethylcellulose (EthC)
Compressible sugar (Nu-tab)
Liquid glucose
Povidone
Pregelatinized starch

A

Binders

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15
Q

TABLET EXCIPIENTS

CMC
CMC Calcium
Microcrystalline cellulose
Starches

A

Disintegrants

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16
Q

TABLET EXCIPIENTS

Colloidal silica
Cornstarch
Talc

A

Glidants

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17
Q

TABLET EXCIPIENTS

Ca/Mg/Zn stearate
Mineral oil
Stearic acid

A

Lubricants

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18
Q

TABLET EXCIPIENTS

Magnesium stearate

A

Anti-adherent

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19
Q

TABLET EXCIPIENTS

Dibasic calcium phosphate (ditab)

A

Direct Compression Excipients

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20
Q

TABLET EXCIPIENTS

FD&C lakes

A

Colors and Dyes

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21
Q

TABLET EXCIPIENTS

MC
EthC
Hydroxy-ethyl/propyl cellulose

A

Film-coating

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22
Q

TABLET EXCIPIENTS

Cellulose acetate phthalate
Shellac (35% in alcohol, “pharmaceutical glaze”)

A

Enteric-coating

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23
Q

TABLET EXCIPIENTS

Liquid glucose
Sucrose

A

Sugar-coating

24
Q

TABLETS FOR ORAL INGESTION

Uncoated tablet manufactured by compression, with sufficient pressure forcing the powders or granules to make the desired shape

A

Compressed tablet

25
TABLETS FOR ORAL INGESTION Designed to disintegrate and release their medication with no specific rate-controlling features
Immediate release tablet
26
TABLETS FOR ORAL INGESTION Designed to release their medication in a predetermined manner over an extended period
Extended-release tablet (controlled-release tablet)
27
TABLETS FOR ORAL INGESTION Coated with a thin layer of polymer capable of forming a skin-like film over the tablet
Film-coated tablets
28
TABLETS FOR ORAL INGESTION Each layer contains a different medicinal agent, separated either due to physical or chemical incompatibility or staged drug release or the manufacturer wants to have a unique appearance of the layered tablets
Multiple-compressed tablets (multi-layered or tablet within a tablet)
29
TABLETS FOR ORAL INGESTION 50% larger and heavier than the original uncoated tablet and time-consuming since it requires 5-6 stages.
Sugar-coated tablet
30
TABLETS FOR ORAL INGESTION Facilitates swallowing and is more tamper-evident than unsealed capsules
Gelatin-coated tablets (GELCAPS)
31
TABLETS FOR ORAL INGESTION Tablet is intact in the stomach but disintegrates in the small intestine
Enteric-coated Tablets
32
TABLETS USED IN ORAL CAVITY These drugs are destroyed by ___ and poorly absorbed in GIT.
gastric juices
33
TABLETS USED IN ORAL CAVITY These tablets are to be dissolved in the buccal pouch (cheek). They are designated to erode slowly (4hrs disintegration time).
Buccal tablets
34
TABLETS USED IN ORAL CAVITY Dissolved under the tongue and absorbed into your blood through the tissue. Dissolve promptly and provide rapid drug effect.
Sublingual tablets
35
TABLETS USED IN ORAL CAVITY They are intended to be dissolved slowly in the oral cavity for localized effects.
Lozenges or Troches
36
TABLETS USED IN ORAL CAVITY Gummy type of lozenges/troches
Pastilles
37
TABLETS USED IN ORAL CAVITY Liquefies or dissolves in the mouth within 1 minute, some within 10 seconds for children and elderly who has difficulty swallowing.
Rapidly Dissolving Tablets
38
TABLETS USED IN ORAL CAVITY Disc-shaped, solid dosage forms containing the medicinal agent and generally a flavoring substance in a hard candy or sugar base.
Lozenges or Troches
39
TABLETS USED IN ORAL CAVITY Disintegrate smoothly and rapidly when chewed or allowed to dissolve in the mouth. Do not contain disintegrants.
Chewable tablets
40
TABLETS USED IN ORAL CAVITY What is used for sugar-free chewable tablets?
Xylitol
41
TABLETS USED IN ORAL CAVITY What is the commonly used excipient in chewable tablets?
Mannitol
42
TABLETS USED TO PREPARE SOLUTION Prepared by compressing granular effervescent salt and releases carbon dioxide when in contact with water
Effervescent tablets
43
TABLETS USED TO PREPARE SOLUTION Prepared by mixing the active drug with lactose, dextrose, sucrose, mannitol, or some other appropriate diluent that can serve as the base
Tablet triturates (Molded tablets)
44
TABLETS USED TO PREPARE SOLUTION Small, usually cylindrical molded or compressed tablet containing small amount of usually potent drugs
Tablet triturates (Molded tablets)
45
TABLETS USED TO PREPARE SOLUTION What is the preferred base for tablet triturates (molded tablets)?
Lactose
46
TABLETS USED TO PREPARE SOLUTION This adds a pleasant, cooling sensation and additional sweetness in the mouth in tablet triturates (molded tablets).
Mannitol
47
OTHER SOLID DOSAGE FORMS FOR ORAL ADMINISTRATION Small, round, solid dosage forms containing a medicinal agent intended to be administered orally
Pills
48
PILL CLASSIFICATION ACCORDING TO WEIGHT Pravules (Small) - potent
20 mg
49
PILL CLASSIFICATION ACCORDING TO WEIGHT Granules
20 to 60 mg
50
PILL CLASSIFICATION ACCORDING TO WEIGHT Pills
60 to 500 mg
51
PILL CLASSIFICATION ACCORDING TO WEIGHT Boluses (big pills) for veterinary use
700 to 2000 mg
52
OTHER SOLID DOSAGE FORMS FOR ORAL ADMINISTRATION Raspberry sugar-based lozenge on a stick containing fentanyl citrate
Lollipop (BN: Actiq)
53
OTHER SOLID DOSAGE FORMS FOR ORAL ADMINISTRATION The first product designed to aid in controlling breakthrough pain in cancer patients that provides immediate relief that lasts for 15 minutes
Actiq
54
OTHER SOLID DOSAGE FORMS FOR ORAL ADMINISTRATION Small, solid particles of uniform shape sometimes called “beads” that can be administered orally or parenterally
Pellets
55
OTHER SOLID DOSAGE FORMS FOR ORAL ADMINISTRATION Used to provide physical separation for chemically or physically incompatible materials, extended release of an API
Pellets