PART 3

Question 1

This is composed of dry aggregates of powder particles.

Answer 1

Granules

Question 2

What are the two methods of granulation?

Answer 2

1. Wet Granulation Method
2. Dry Granulation Method

Question 3

What sieve size is required for granules used in tablet formulation?

Answer 3

No. 12-20

Question 4

What is the usual sieve size range for granules?

Answer 4

No. 4-12

Question 5

True or False

Granules are more stable to the effects of atmospheric humidity, more likely to cake or harden upon standing, and more easily wetted.

Answer 5

False, less likely to cake or harden

Question 6

Method of granulation for drugs that are moisture sensitive or heat liable

Answer 6

Dry Granulation Method

Question 7

The water of crystallization from ___ serves as a binding agent in dry granulation method.

Answer 7

Citric acids

Question 8

During dry granulation method, heating causes the release of ___ from the citric acid.

Answer 8

Water of crystallization

Question 9

What are the binding agents used in wet granulation method?

Answer 9

1. Water
2. Ethanol
3. Isopropyl alcohol

Question 10

Granules or coarse to very coarse powders containing
a soluble medicinal agent in a dry mixture.

Answer 10

Effervescent granulated salts

Question 11

3 components of effervescent granulated salts

Answer 11

1. Sodium bicarbonate
2. Citric acid
3. Tartaric acid

Question 12

Ratio requirement for citric acid and tartaric acid in effervescent granulated salts.

Answer 12

1 citric: 2 tartaric

Question 13

___ acid alone results to granules readily losing its firmness and crumbling.

___ acid alone results in a sticky mixture difficult to granulate

Answer 13

1. Tartaric
2. Citric