Part 3 Gyn. Infections Flashcards
Presentation of Genital Herpes?
Painful genital sores
Bilateral LAD
Presentation of Genital Herpes?
Painful genital sores
Bilateral LAD
If the Genital Herpes is RECURRENT, how will it present?
Cluster of vesicles that will rupture and ulcerate
LAD on 1 side
Recurrent Genital Herpes is latent where? Is it more severe or less severe than the primary presentation?
Sacral Ganglia
– LESS severe
HSV is a lifelong DNA virus. HSV 1 and 2 usually affect what areas?
HSV1 = orofacial HSV2 = genital
If you see “molding, multinucleation, margination” on biopsy, think?
HSV
The treatment for Genital Herpes uses what MOA?
(-) DNA synthesis
What are 3 treatment options for Genital Herpes that (-) DNA synthesis?
- Acyclovir
- Valacyclovir
- Famciclovir
What are 3 treatment options for Genital Herpes that (-) DNA synthesis?
- Acyclovir
- Valacyclovir
- Famciclovir
How does Acyclovir Resistance develop?
Decreased production of viral thymidine kinase
=> NO activation of Acyclovir
What bacteria causes Syphilis?
Treponema Pallidum
What will be seen on stain and biopsy with Treponema Pallidum?
Stain = corkscrew Biopsy = lymphoplasmacytic infiltrate
With Syphilis, what develops 3-6 weeks after sexual contact?
PainLESS Chancre
Primary syphilis
PainLESS chancre 6 weeks after sexual contact
6 weeks after the painless chancre with primary syphilis, what will present?
Condyloma latum
Macular red rash involves palms and soles
Patchy hair loss
Secondary Syphilis
Condyloma Latum
Macular red rash involving palms/soles
Patchy hair loss
6-40 years after secondary syphilis, what arises?
Gummatous lesions
Thoracic Aortic Aneurysm
Tabes Dorsalis
Tabes Dorsalis affects the posterior columns and dorsal root. What are the symptoms?
Decreased coordination, pain, temperatures sensation
Loss of proprioception
What are Argyll Robertson pupils that can be seen with Tertiary Syphilis?
(-) light reflex
(+) accommodation reflex
Tertiary Syphilis
Gummatous lesions
Thoracic Aortic Aneurysm
Tabes Dorsalis
What are 2 non-treponemal screens that if they come back positive, you should do a specific one?
RPR
VDRL
What is a specific treponemal screen for syphilis?
FTA-ABS
What is the treatment for primary or secondary Syphilis?
Benzathine Penicillin
– or Doxycycline
What is the treatment for Primary or Secondary Syphilis?
Benzathine Penicillin
– Or Doxycycline
MOA for the drugs that treat syphilis?
(-) cell wall synthesis
What organism usually causes Toxic Shock Syndrome?
Staph. Aureus
What are the attributes of Staph. Aureus?
Gram (+) cocci in clusters
- Catalase and Coagulase (+)
What are the symptoms of Toxic Shock Syndrome?
Fever
Macular rash that involves the palms and soles
–> desquamation of the skin
Multi-organ involvement and Hypotension
What is the action of the TSST-1 Toxin with toxic shock syndrome?
Crosslinks T cells and macrophages
=> releases cytokines
Fever, macular rash that involves the palms and soles that then desquamates, hypotension and organ involvement is likely?
Toxic Shock Syndrome
