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SEM2 - I/S > Part 3 cytokines, complement > Flashcards

Part 3 cytokines, complement Flashcards

1
Q

small soluble prot that regulates the immune sys, both innate and adaptive

A

cytokines

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2
Q

IL 1

A

proinflammatory cytokines by mono and macro

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3
Q

induces fever, pyrogen

A

il1

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4
Q

cachectin

A

tnf alpha

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5
Q

affects infla, APR, ig synth, actv of b and t

A

IL-6

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6
Q

family of cytokines that enhance motility and promote migration of wbcs

A

chemokines

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7
Q

“immune interferon”

A

INF gamma

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8
Q

t-cell growth factor

A

IL2

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9
Q

stimulates antigen presentation by mhc i and mhc molec

A

IFN

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10
Q

drives the growth and differentiation of both T and B cells

A

IL2

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11
Q

regulates t-cells helps and drive Ab responses in a variety of diseases

A

IL4

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12
Q

has anti inflamm and suppress fx on helper t cells

A

IL10

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13
Q

most plasma compo prot are synthes in the LIVER except

A

C1 compo - intestinal epith cell
Factor D - adipose tissue
Zymogens (inactive precursors)

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14
Q

complement fxns

A

Opsonic fxn
Inflammatory fxn
cytotoxic fxn

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15
Q

anaphylatoxin

A

c4a
c3a
c5a

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16
Q

best activator is igM

A

classical pathway

17
Q

classical pathwy recog unit

A

c1

18
Q

classical path c

A

c1q c1r c1s

19
Q

cleaves c4, c2

A

c1s

20
Q

convertase

A

c3

21
Q

Class path
activation unit
membrane attack

A

act uni C423

memb atta C56789

22
Q

Alternative pathway bypasses

A

C142

23
Q

Alternative pathway BEGINS with

A

C3

24
Q

mostly activated by polysacc and IgA

A

alternative path

25
Q

initiated by mo w/ mannose

A

lectin pathway

26
Q

lectin pathway 2

A

MBL

MASP

27
Q

fxn of anaphylatox

A

release of vasoactive amine
incr smooth muscle contraction
incr capillary permea

28
Q

cleaves c4 and c2 forming c3 convertase then class path

A

MASP

29
Q

opsonin

chemotaxin

A

c3b

c5a

30
Q

c3 convertase
classical
altern

A

c= c4b2a

a=c3bBb

31
Q

c5 convertase
c
a

A 
c= c4b2a3b
a= c3bBb3b

SEM2 - I/S (7 decks)

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