Immunology 2

Question 1

factors contributing to autoimmunity

Answer 1

MHC products
release of sequestered antigens
molecular mimicry
polyclonal b-cell activation

Question 2

spec. autoab seen in active stages of sle = 
drug-induced sle =
diagnostic for sle = 
SLE, mixed connective tissue dse = 
SLE, systemic sclerosis =

Answer 2

Anti-dsDNA
Anti-histone/anti-DNP
Anti-Sm
Anti-RNP
Anti-nucleolar

Question 3

neutrophil that has engulfed the ab-coated nucleus of another neutrophil

specimen:

Answer 3

LE cell

buffy coat

Question 4

Staining patterns of FANA

1. homogenous or peripheral pattern
2. homogenous pattern
3. speckled pattern
4. finely speckled
5. nuceolar staining pattern

Answer 4

1. anti-dsdna & anti-histone
2. anti-dnp
3. anti-sm & RNP
4. anti-SS-A/Ro & -B/La
5. anti-nucleolar RNA

Question 5

IgM reacting against Fc portion of IgG

Answer 5

RF

Question 6

RA lab test

sheep cell agglu
LAT
sensitized alligator erythrocyte test
bentonite flocculation test

Answer 6

RF in serum/synovial fluid

rose-waaler
singer and plotz
cohen et al
bloch and bunim

Question 7

autoimmune thyroid dses

Answer 7

Hashimotos thyr - anti-thyroglobulin, anti-microsomal

Graves - anti-TSHr, anti-TPO

Question 8

1 Type I DM
2 Multiple sclero
3 Myasthemia gravis
4 Goodpasteur
5 Primary biliary cirrhosis
6 chornic active hepa
7 pernicious anemia
8 sjogren's syndrome
9 scleroderma/CREST syndrome

Answer 8

1 anti-islets cells ab
2 anti-mbp
3 anti-acetylcholine receptors
4 anti-glomerular basement membrane
5 anti-mitochondrial
6 anti-smooth muscle
7 anti-parietal
8 anti-salivary and anti-lacrimal glands
9 anti-centromere ab

Question 9

hodgkins dse

non-hodgkin dse

Answer 9

presence of Reed-sternberg cells; cd15 and cd30 +

b cell lymphoma

Question 10

monoclonal ig component in plasma (paraproteins)

Answer 10

MM

Question 11

excessive IgM

hyperviscosity syndrome

Answer 11

waldenstrom’s macroglobulinemia

Question 12

Lab eval
Leukemia & lymphoma
plasma cell dyscrasia

Answer 12

flow cyto

serum ig lvls and SPE

Question 13

b cell system defects 4

Answer 13

X-linked bruton’s agammaglo
iga dfncy
common variable immunodefncy
igg subclass dfncy

Question 14

t cell system defects

Answer 14

digeorge anomaly
severe combined immunodfncy
wiskott aldrich syndrome
ataxia telangiectasia
chronic granulomatous dse

Question 15

wiskott triad

Answer 15

immunodfncy
eczema
thrombocytopenia

Question 16

CGD test

Answer 16

nitroblue tetrazolium test

Question 17

spotted fever

typhus

scrub typhus

q fever

Answer 17

r.rickettsii -RMSF
akari -rickpox
australis -australian tick typ
conorii -boutenneuse fever
------
r. prowazekii -epidemic typ; sporadic typ; brill-zinsser dse (recrude typ)
typhi -endemic
------
tsutsu
----
cox burnetii

Question 18

Lab work up ricket infxn

Answer 18

IFA -gold
micro-IF
IPA
ELISA

Question 19

OX-19
OX-2
OX-K

Answer 19

Proteus vulgaris
Proteus vulgaris
P. mirabilis

Question 20

H.pylori work up

Answer 20

EIA stool -detects Ag

EIA serum -detects IgG or IgM

Question 21

m.pneumoniae work up

Answer 21

cold agglu
eia on serum
ifa

Question 22

nontreponemal test types

Answer 22

VDRL
RPR
TRUST
USR
RST

Question 23

treponemal test types

Answer 23

TPI
FTA-ABS

HATTS
TPHA
MHA-TP

Question 24

uses glutaraldehyde-stab turkey RC sensi with nichol’s strain

Answer 24

HATTS

TPHA

Question 25

USES FORMALIZED SHEEP RBCs sensi with nichols

Answer 25

MHA-TP

Question 26

lyme dse screening test

Confirm

Answer 26

IFA

Western blot