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SEM2 - I/S > IS PART 2 - Immunoglobulins > Flashcards

IS PART 2 - Immunoglobulins Flashcards

1
Q

glycoprot found in the serum portion of blood

A

immunoglo

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2
Q

ig are composed of

A

82-96% polypep

2-14% carbs

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3
Q

ig migrates at the gamma reg when subj to ph

A

8.6

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4
Q

major humoral component of adaptive iR

A

ig

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5
Q

intrachain and interchain bonds

A

disulfide bonds

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6
Q

flexible reg of ig: allows for movement of the fab arms

A

hinge reg

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7
Q

hinge region is rich in

located between

A

proline

ch1 and ch2

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8
Q

domains
1 LC =
1 hc =

A 
lc = vl + cl
hc = vh + 3ch Ig'GAE'
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9
Q

isotype
allotype
idiotype

A 
heavy chain det ig class
constant reg
variable reg
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10
Q

basic ig structure

A

monomer
2h + 2lc
ig GDE

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11
Q

2 monomers with secretory component and j chain

A

dimer - igA

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12
Q

pentamer

A

IgM polymer (crab, star)

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13
Q

fragment igm by 2

A

2-mercaptoethanol (used in bb)

dithiotreitol (dtt)

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14
Q

fragment monomer by 2

A

papain

pepsin

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15
Q

cleaves above hinge; 3 fragments… 2fab 1fc

below ; 2 frag …2fab

A

papain

pepsin

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16
Q

fxn of fc

A

biologic act
comple fixa
skin fixa
placental trans

17
Q

major ig in adults

A

igG

18
Q

maj Ab in secondary IR

A

IgG

19
Q

IgG1
2
3
4

A 
66% = 2 disfb
23 = 4 disfb
7 = 15
4 = 2
20
Q

Ig crosses placenta
most effective
least

A

igG1

igG2

21
Q

fixation complement
most effective
least

A

igG3

igG4

22
Q

best in agglu

best in precip

A

igM

igG

23
Q

most efficient in complement fixa and agglu

A

igM

24
Q

igA1

igA2

A 
serum = monomer
secretions = dimer
25
Q

immunoregulation

A

igD

26
Q

primarily a cell mem ig found on surf of b ce together w/ igM

A

igD

27
Q

heat labile ab, reagenic ab

A

igE

28
Q

mediates release of histamine and heparin

A

igE

SEM2 - I/S (7 decks)

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